The triglyceride-to-high density lipoprotein cholesterol ratio in overweight Korean children and adolescents

Yoo, Doo-Yeol; Kang, Yu Sun; Kwon, Eun Byul; Yoo, Eun-Gyong

doi:10.6065/apem.2017.22.3.158

Cited by 16 publications

(23 citation statements)

References 34 publications

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“…Both TG/HDL-C and non-HDL-C correlate well with the increased number of sd-LDL-C particles, however based on AUC, non-HDL-C appears to be slightly better when compared to the TG/HDL-C ratio in the diagnosis of dyslipidemias among children in non-fasting condition [ 15 ]. Yoo et al showed TG/HDL-C to be a good predictor of cardiovascular disease in obese children and adolescents, as well as highlighting on association with insulin resistance, though recent lipid screening guidelines for children recommend non-HDL-C as a universal screening test in non-fasting condition [ 25 ]. In agreement with the Bogalusa Heart Study and the National Heart, Lung, and Blood Institute, non-HDL-C is considered a reliable marker in the screening of dyslipidemias in children [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Non-fasting lipid profile determination in presumably healthy children: Impact on the assessment of lipid abnormalities

et al. 2018

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ObjectiveDespite the common use of non-fasting measurements for lipid profile in children it remains unclear as to the extent non-fasting conditions have on laboratory results of lipids measurements. We aimed to assess the impact of non-fasting lipid profile on the occurrence of dyslipidemia in children.Materials and methodsBasic lipid profile including: total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG), as well as small, dense-LDL-C (sd-LDL-C), apolipoprotein AI (ApoAI), apolipoprotein B (ApoB) and lipoprotein(a) [Lp(a)], were measured in 289 presumably healthy children aged 9–11 in both fasting and non-fasting condition. The clinical impact of non-fasting lipid profile was evaluated individually for each child with estimation of false positive (FP) and false negative (FN) results.ResultsThe highest percentage of FP results in non-fasting condition was observed for TG (42.3%) being significantly higher when compared to FN results (p = 0.003). In contrast, the highest percentage of FN results in a non-fasting state were shown for LDL-C (14.3%), but the difference was statistically insignificant when compared to FP results. When comparing fasting and non-fasting lipid profile a number of significant differences was shown for: TG (p<0.001), HDL-C (p = 0.002) LDL-C (p<0.001) and ApoAI (p<0.001), respectively. The occurrence of dyslipidemia, recognized on the basis of non-fasting lipids was significantly higher (p = 0.010) when compared to fasting lipid profile.ConclusionsA higher occurrence of dyslipidemia, based on the measurement of non-fasting lipids in children, is suggestive of possible disorders in lipid metabolism. However, accurate identification of dyslipidemia by assessment of non-fasting lipids requires the establishment of appropriate cut-off values for children.

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Section: Discussionmentioning

confidence: 99%

Non-fasting lipid profile determination in presumably healthy children: Impact on the assessment of lipid abnormalities

et al. 2018

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“…Their levels of total cholesterol (TC) were 172.0 mg/dL, low-density lipoprotein cholesterol (LDL) was 106.54 mg/dL and they had a high-density lipoprotein cholesterol (HDL) of 50.0 mg/dL (171.0, 101.0 and 49.0 mg/dL, as averages of the last three years, respectively). Concerning to triglycerides (TG), girls showed a concentration of 90.0 mg/dL in the latest year (86.0 mg/dL as median for three years), and thus the risk scores for atherosclerosis (TC/HDL ratio) and that for insulin resistance (TG/HDL ratio) were 3.46 and 1.67, respectively (3.57 and 1.84 for the last three years), which fell within the normal ranges [23][24][25]. Body mass index (BMI) was 21.25 kg/m 2 , with BMI-SDS of 0.59 and height-SDS of −0.77, and their waist circumference (WC) was 71.77 cm (Table 1).…”

Section: Characterization Of the Uncontrolled T1dm Populationmentioning

confidence: 89%

“…They exhibited TC levels of 163.5 mg/dL and had an LDL of 98.32 mg/dL and HDL of 43.5 mg/dL (169.5, 96.0 and 49.0 mg/dL as averages of the last three years, respectively). In boys, the median of TG levels was 83.5 mg/dL (80.0 mg/dL in the last three years) and thus the ratios for TC/HDL and TG/HDL were 3.44 and 1.71, respectively (3.39 and 1.72 in the last 3 years), falling also within the safety ranges [23][24][25]. The BMI was 20.61 kg/m 2 , with BMI-SDS of 0.51 and height-SDS of −0.80, and the WC was 71.06 cm (Table 1).…”

Section: Characterization Of the Uncontrolled T1dm Populationmentioning

confidence: 93%

Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control

Khedr

Hafez

Lumpuy‐Castillo

et al. 2020

IJMS

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Uncontrolled type-1 diabetes (T1DM) can lead to dyslipidaemia and albuminuria, which may promote cardiovascular injuries. However, some lipidemic factors could be useful in predicting cardiac dysfunction. Seventy-eight adolescents under insulin treatment due to a 6-year history of T1DM and were retrospectively examined. Glycemia, lipidemia, and albuminuria were measured in addition to development of cardiovascular abnormalities Both girls and boys showed higher HbA1c and fasting blood glucose and 27.1% females and 33.3% males exhibited microalbuminuria though their plasma levels of total cholesterol (TC), triglycerides (TG), and low-density lipoproteins (LDL) and high-density lipoproteins (HDL lipoproteins were in the normal range. They exhibited a preserved systolic function, but 50% of females and 66.6% of males had developed diastolic failures. Interestingly, girls with diastolic dysfunction showed significantly lower concentrations of HDL and higher TC/HDL and TG/HDL ratios. In fact, low HDL levels (OR 0.93; 95% CI 0.88–0.99; p = 0.029) and high TC/HDL (OR 2.55; 95% CI 1.9–5.45; p = 0.016) and TG/HDL (OR 2.74; 95% CI 1.12–6.71; p = 0.028) ratios associated with the development of diastolic complications. The cut-off values for HDL, TC/HDL, and TG/HDL were 49 mg/dL, 3.0 and 1.85, respectively. HDL and TC/HDL and TG/HDL ratios may be useful for predicting diastolic dysfunction in girls with uncontrolled T1DM.

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“…Whole IR was calculated with HOMA-IR according to Matthews et al 26 , and children were classified as having IR according to cutoff values from previous work in Mexican population 27 . The TG/high-density lipoprotein cholesterol index (I-TG/HDL-C) was calculated, which is an indirect method for IR proposed by Quijada et al 28 , and values > 2.0 were considered as a cardiovascular risk factor 29 .…”

Section: Biochemical Measurementsmentioning

confidence: 99%

Insulin-Like growth factor binding Protein-1, non-alcoholic fatty liver disease, and its relationship with fructose consumption in children with obesity

Flores-Ramírez

Ibarra-Reynoso

López-Lemus

et al. 2020

RIC

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Background: Over consumption of added sugar is associated with obesity, non-alcoholic fatty liver disease (NAFLD), and insulin resistance (IR). Objective: The objective of the study was to study the insulin-like growth factor binding protein-1 (IGFBP-1) and NAFLD and their relationship with fructose consumption in children with obesity. Methods: A cross-sectional study was carried out in children 6-11 years old with obesity. Anthropometric measurements, fructose consumption, glucose, lipid profile, insulin, and IGFBP-1 levels were evaluated; the homeostatic model assessment of IR (HOMA-IR) was used. NAFLD was evaluated by ultrasound. Results: We studied 83 children with a mean age of 9.2 ± 1.3 years. About 93% of the girls presented IR and lower levels of IGFBP-1 (p = 0.0001). The group with the lower levels of IGFBP-1 had higher HOMA-IR (p = 0.000002); IGFBP-1 was associated with fructose consumption (r = −0.25; p = 0.03), body mass index (BMI) (r=−0.42; p = 0.02), and HOMA-IR (r=−0.61; p = 0.002). About 81% of the children were classified as having mild or moderate/severe NAFLD, and these groups had higher HOMA-IR (p = 0.036) and fructose consumption (p = 0.0014). Conclusions: The girls had more metabolic alterations. The group with lower levels of IGFBP-1 (hepatic IR) was associated with higher BMI, HOMA-IR, and fructose consumption; the group with higher severity of NAFLD showed higher HOMA-IR and fructose consumption.

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The triglyceride-to-high density lipoprotein cholesterol ratio in overweight Korean children and adolescents

Cited by 16 publications

References 34 publications

Non-fasting lipid profile determination in presumably healthy children: Impact on the assessment of lipid abnormalities

Non-fasting lipid profile determination in presumably healthy children: Impact on the assessment of lipid abnormalities

Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control

Insulin-Like growth factor binding Protein-1, non-alcoholic fatty liver disease, and its relationship with fructose consumption in children with obesity

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