The triglyceride/HDL-cholesterol ratio as a marker of cardiovascular risk in obese children; association with traditional and emergent risk factors

Quijada, Zaira; Paoli, Mariela; Zerpa, Yajaira; Camacho, Nolis; Cichetti, Rosanna; Villarroel, Vanessa; Arata-Bellabarba, Gabriela; Lanes, Roberto

doi:10.1111/j.1399-5448.2008.00406.x

Cited by 125 publications

(106 citation statements)

References 45 publications

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“…La alta frecuencia de hipertrigliceridemia y C-HDL bajo encontradas resulta preocupante, debido a su asociación con síndrome metabólico 26,27 y ECV 28 . Además, la DA en la infancia es predictiva de aterosclerosis acelerada y eventos cardiovasculares tempranos en la vida adulta 7 .…”

Section: Discussionunclassified

Alta frecuencia de dislipidemias en niños y adolescentes con Síndrome de Down

Piedra

Alberti

Cerda

et al. 2017

Rev. chil. pediatr.

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ResumenEl síndrome de Down (SD) presenta mayor riesgo de desarrollar enfermedades crónicas asociadas a mayor morbimortalidad por enfermedad cardiovascular. Algunos estudios han mostrado un peor perfil lipídico en niños con SD, sin embargo, hasta el momento no existen recomendaciones de tamizaje para dislipidemia en estos pacientes. Objetivo: Describir la frecuencia de dislipidemia en una población chilena de niños y adolescentes con SD. Pacientes y Método: Estudio retrospectivo, que incluyó pacientes con SD entre 2 y 18 años, participantes de un programa de salud para personas con SD en la Red de Salud UC CHRISTUS, entre los años 2007 y 2015. Se incluyeron pacientes que tuvieran perfil lipídico tomado entre sus exámenes de rutina. Se registraron características clínicas, comorbilidades relevantes, malformaciones, medicamentos, estado nutricional y estado puberal. El diagnóstico de dislipidemias se realizó de acuerdo a los criterios de la NHLBI 2011. Resultados: Se revisaron las fichas clínicas de 218 niños con SD, 58,3% tenía algún tipo de dislipidemia. Las más frecuentes fueron colesterol HDL bajo (15,1%) e hipertrigliceridemia (12,8%). La dislipidemia aterogénica (C-HDL bajo más hipertrigliceridemia) fue la dislipidemia combinada más frecuente (13,3%), la cual no se asoció a sobrepeso u obesidad. Conclusiones: Se encontró una alta frecuencia de dislipidemia en niños y adolescentes chilenos con SD. Nuestros resultados nos hacen sugerir la realización de un perfil lipídico de forma temprana a todos los pacientes con SD, independiente de la presencia de factores de riesgo de dislipidemia.

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Section: Discussionunclassified

Alta frecuencia de dislipidemias en niños y adolescentes con Síndrome de Down

Piedra

Alberti

Cerda

et al. 2017

Rev. chil. pediatr.

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“…23 By considering 1 SD above or below the mean as abnormal, five subjects (16.7%) in the young family group were above this cutoff point. Interestingly, three of these individuals had normal or low BMI (data not shown).…”

Section: Children/adolescentsmentioning

confidence: 99%

Metabolic syndrome and related variables, insulin resistance, leptin levels, and PPAR-γ2 and leptin gene polymorphisms in a pedigree of subjects with bipolar disorder

Baptista¹,

Sandia²,

Fernández

et al. 2015

Rev. Bras. Psiquiatr.

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Objective: Evidence points to a high prevalence of metabolic dysfunction in bipolar disorder (BD), but few studies have evaluated the relatives of subjects with BD. We conducted a cross-sectional study in an extended family of patients with BD type I. Methods: The available relatives of the same family were interviewed (DSM-IV-R) and assessed in fasting conditions for body mass index, constituent variables of the metabolic syndrome (MS), leptin levels, insulin resistance index, and single nucleotide polymorphisms (SNPs) for the leptin receptor and promoter and PPAR-c2 genes. The frequency of MS was compared with that recorded in the local general population. Results: Ninety-three relatives of three adults with BD were evaluated (30 aged , 18 years, 63 aged . 18 years). The frequency of MS was similar to that of the general population. Significantly higher frequencies of abnormal glucose, total and low density cholesterol (LDL-c) levels (all p , 0.05), waist circumference (p = 0.057), and leptin and insulin resistance values (in adults only) were observed in the family. Adults with the QQ genotype of the leptin receptor displayed higher LDL-c levels than carriers of the R allele. Conclusions: The associations among BD consanguinity, familial hypercholesterolemia, and leptin receptor SNPs reported herein should be replicated and extended in other pedigrees.

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“…Previous studies have demonstrated that fasting insulin and homeostasis model assessment (HOMA) are markers of IR [7] but there has been no attempt to standardize assays of insulin concentration to date. The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio concentration has been reported to be closely related to IR in adults [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Is triglyceride to high-density lipoprotein cholesterol ratio a surrogates for insulin resistance in youth?

Oliveira¹,

Oliveira²,

Oliveira³

et al. 2013

Health

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As elevated triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio has been described as predictor for cardio metabolic disease with insulin resistance (IR) in the background, the aim was to assess the relationship between this ratio and IR in youth. Oral glucose tolerance test was performed in 318 Brazilian students (175 girls, 11.2 ± 3.2 years, BMI_z-score 1.2 ± 1.4 SD). Measurements: BMI, waist circumference (WC), blood pressure (BP), lipids, insulin and high sensitivity C-reactive protein (hsCRP). Excessive weight and abdominal obesity were defined using BMI_z-score and WC and IR by Homeostasis model assessment-insulin resistance (HOMA-IR). TG/HDL-C median was 2.37. There was an association between TG/ HDL-C and WC, systolic and diastolic BP, insulin, HOMA-IR, hsCRP, (p < 0.001). Stratified TG/HDL-C into two groups, based on a cut off point of 2.73 (Group 1: <2.73 and Group 2: ≥2.73). Adjusting for age, gender, ethnicity TG/HDL-C was an independent variable predicting IR (PR = 1.44; CI: 1.07 -1.96; p = 0.018). For every 1 (cm) in WC increased there was an addition of 0.04 of the value of TG/HDL-C and in those with TG/HDL-C ≥ 2.73 for every 10 (cm) increase in WC there was an improve of 4% in the ratio. In conclusion: In youth, the TG/HDL-C ratio could be a useful index for identifying groups with IR.

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The triglyceride/HDL-cholesterol ratio as a marker of cardiovascular risk in obese children; association with traditional and emergent risk factors

Abstract: Obesity increases the cardiovascular risk in childhood. The Tg/HDL-C ratio could be a useful index in identifying children at risk for dyslipidemia, hypertension, and MS.

Cited by 125 publications

References 45 publications

Alta frecuencia de dislipidemias en niños y adolescentes con Síndrome de Down

Alta frecuencia de dislipidemias en niños y adolescentes con Síndrome de Down

Metabolic syndrome and related variables, insulin resistance, leptin levels, and PPAR-γ2 and leptin gene polymorphisms in a pedigree of subjects with bipolar disorder

Is triglyceride to high-density lipoprotein cholesterol ratio a surrogates for insulin resistance in youth?

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