The Triglyceride Connection in Atherosclerosis

Geurian, K; Pinson, J B; Weart, C. Wayne

doi:10.1177/106002809202600913

Cited by 30 publications

(14 citation statements)

References 59 publications

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“…Particularly atherogenic forms of LDL include small, dense LDL particles and oxidized LDL (9). An elevation of VLDL is also associated with increases in prothrombotic and procoagulant factors (11). All lipoproteins that contain apolipoprotein B tend to promote atherosclerosis (12,13).…”

Section: Discussionmentioning

confidence: 99%

Non-HDL Cholesterol as a Predictor of Carotid Atherosclerosis in the Elderly

Kawamoto

Oka

Tomita

et al. 2005

JAT

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The aim of the present study was to evaluate sclerotic lesions of the common carotid artery by ultrasonography in 921 in-patients aged 65 years and older (77 ± ± ± ± ± 7 years) and investigate whether lipid levels were associated with carotid atherosclerosis. In men, an increased risk for carotid atherosclerosis was associated with increased levels of low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C). Compared to men with the lowest tertile of LDL-C levels (< 83.4 mg/dl), the adjusted odds ratio was 2.502 (95% confidence interval:

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Section: Discussionmentioning

confidence: 99%

Non-HDL Cholesterol as a Predictor of Carotid Atherosclerosis in the Elderly

Kawamoto

Oka

Tomita

et al. 2005

JAT

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“…The data gave us a clue that H 2 might regulate the metabolism of LDL-C by decreasing the synthesis of apoB or increasing the catabolism of LDL-C . Second, like LDL-C, VLDL-C is considered a type of ''bad'' cholesterol because elevated levels are associated with an increased risk of coronary artery disease ( 27 ). We found that apoB and apoE, the major proteins in VLDL, were lowered by H 2 , although cholesterol analysis by FPLC revealed no changes of was not altered signifi cantly after intake of H 2 water (data not shown), which might be attributable to the sensitivity of Griess method.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome

Song¹,

Song

et al. 2013

Journal of Lipid Research

117

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“…There is little information concerning this issue so far in the literature. An in-depth study on this point may help in understanding the pathophysiology of hyperlipidemia-induced atherosclerosis, since accumulating evidence from human studies has shown that hyperlipidemia is a major cause of atherosclerosis and cardiovascular disease (CVD) (5)(6)(7), that different types of leukocytes are likely to play important but different roles in atherosclerosis (8)(9)(10), and that a higher peripheral total leukocyte count is associated with an increased incidence of CVD (3,(11)(12)(13). In addition, because cigarette smoking and obesity are frequently found in association with both lipid disorders (14-16) and a higher peripheral leukocyte count (1,3,13,(17)(18)(19), we included the factors of smoking and body mass index (BMI) in the study.…”

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confidence: 99%

Peripheral differential leukocyte counts in humans vary with hyperlipidemia, smoking, and body mass index

Huang

Chien

Yang

et al. 2001

Lipids

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Reports of diverse relationships between blood concentrations of different lipids and peripheral total leukocyte count, and a unique lower peripheral monocyte count in hypercholesterolemia, have driven us to think that in humans, peripheral differential leukocyte counts may be influenced differently by different types of hyperlipidemia. Our subjects were Taipei residents who attended a regular health check program in our hospital in 1998. A total of 3,282 subjects was enrolled, including 1,677 normolipidemic, 960 untreated borderline hyperlipidemic, and 645 untreated hyperlipidemic subjects. By one-way analysis of variance (ANOVA), we found that different types of hyperlipidemia were associated with significant differences in differential leukocyte counts. In hypertriglyceridemia, the total leukocyte count and counts of all leukocyte subtypes were significantly higher than those in normolipidemia. Pure hypercholesterolemia, by contrast, was associated with a significantly lower monocyte count and no significant difference in other leukocyte counts. By two-way ANOVA adjusted for presence and degree of hyperlipidemia, we found significantly higher counts of total leukocytes and of all leukocyte subtypes in smokers, and significantly positive trends in relationships between body mass index (BMI) and counts of all leukocytes, neutrophils, lymphocytes, and monocytes. By multivariate regression analysis including all subjects, the serum triglyceride (TG) level was positively correlated with total leukocyte count and counts of all subtypes except eosinophils. On the contrary, serum high density lipoprotein-cholesterol had a negative correlation with total leukocyte count and with counts of neutrophils, monocytes, and basophils. In these multivariate regression analyses, there was no significant correlation between lipid levels and eosinophil count, whereas smoking was consistently associated with significantly higher counts of all leukocyte subtypes, including eosinophils. BMI had a significantly positive correlation with counts of all leukocytes, neutrophils, lymphocytes, and monocytes.

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The Triglyceride Connection in Atherosclerosis

Cited by 30 publications

References 59 publications

Non-HDL Cholesterol as a Predictor of Carotid Atherosclerosis in the Elderly

Non-HDL Cholesterol as a Predictor of Carotid Atherosclerosis in the Elderly

Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome

Peripheral differential leukocyte counts in humans vary with hyperlipidemia, smoking, and body mass index

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