Non-HDL Cholesterol as a Predictor of Carotid Atherosclerosis in the Elderly

Abstract

The aim of the present study was to evaluate sclerotic lesions of the common carotid artery by ultrasonography in 921 in-patients aged 65 years and older (77 ± ± ± ± ± 7 years) and investigate whether lipid levels were associated with carotid atherosclerosis. In men, an increased risk for carotid atherosclerosis was associated with increased levels of low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C). Compared to men with the lowest tertile of LDL-C levels (< 83.4 mg/dl), the adjusted odds ratio was 2.502 (95% confidence interval:

Impact of C-reactive Protein on the Likelihood of Carotid Atherosclerosis in Japanese Adults

“…Moreover, with respect to carotid atherosclerosis, which is a useful tool to predict the likelihood of cardiovascular disease 6,7) and is related to many atherosclerotic risk factors 8,9) , an association between CRP levels and the presence of carotid plaques has been shown in univariate analysis in a prospective survey conducted in the general community (age range, 40 to 79 years) 10) or in healthy middle-aged women with a history of smoking 11) . However, Tracy et al 12) failed to demonstrate a relationship between CRP and carotid arterial intima-media thickness (IMT) and plaque.…”

Diabetes Associated to Atherosclerosis Risk Factors in Patients of Family Health Unity

“…The dyslipidemias arise from physiological changes that result in serum values above or below the desirable for CT (total cholesterol), LDL-C (LDL cholesterol), TG (triglycerides), relations CT/HDL-C and LDL-C/HDL-C and for the fraction non-HDL-C (non-HDL cholesterol), but mainly when HDL-C (HDL cholesterol) is below the desirable [18]- [20]. HDL-C is one of the most promising indicators to determine risk of atherosclerotic cardiovascular disease [21]. There is an increased risk with the growth of LDL-C, non-HDL-C, CT, and the biggest ratio CT/HDL-C has a positive linear relationship with Atherosclerotic cardiovascular disease, as well as LDL-C, especially in elderly patients.…”

“…There is an increased risk with the growth of LDL-C, non-HDL-C, CT, and the biggest ratio CT/HDL-C has a positive linear relationship with Atherosclerotic cardiovascular disease, as well as LDL-C, especially in elderly patients. The increase in the rates of CT, LDL-C, non-HDL-C, apoB, TC/HDL-C, LDL-C/HDL-C, and apoB/apoA-I are associated with the presence of atherosclerotic plaque [21] [22], but highlighting the ratio CT/HDL-C. By de way, the non-HDL-C could be usefulness as a risk marker of cardiovascular disease [23], and non-HDL-C would be more related to apoB than with the LDL-C, having the same predictive value that these lipoproteins. Therefore, the increased level of HDL-C is associated with the decrease in the thickening of the intima of carotid average in patients with type 2 DM and atherosclerosis [24].…”

Proposed Guidelines for Hypertriglyceridemia in Japan with Non-HDL Cholesterol as the Second Target

“…Several studies have indicated that non-HDL cholesterol is better than LDL cholesterol in its predictive power of cardiovascular diseases, indicating that VLDL cholesterol could contribute to CVD 12) . Non-HDL cholesterol is also a useful marker in a variety of subpopulations: men, the elderly, and patients with high-risk diseases such as diabetes and end-stage renal disease [13][14][15][16] . Our current clinical data from patients with type b hyperlipidemia also support the usefulness of non-HDL cholesterol ( Table 1).…”