The tridimensional ultrastructure of fenestrated capillaries

Friederici, H.H.R.

doi:10.1016/s0022-5320(68)80109-1

Cited by 59 publications

(17 citation statements)

References 12 publications

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“…Among the latter, the plasmalemmal vesicles in the endothelium of muscular capillaries and the fenestrae in that of visceral capillaries are of particular importance, since they have been implicated in the movement of water and water-soluble molecules across the endothelial layer (2,(3)(4)(5)(6)(7)(8) . A number of incidental observations have already mentioned an uneven distribution of fenestrae and vesicles in a variety of capillaries (6,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) . Moreover, in a recent paper (8) we have distinguished in the endothelial 1 28 cell of the blood capillaries of the rat diaphragm four differentiated parts, and we have shown that these parts participate unequally in the transport of myoglobin used as an exogenous tracer .…”

Section: Introductionmentioning

confidence: 99%

Morphometric Data on the Endothelium of Blood Capillaries

Simionescu

Simiónescu

Palade

1974

The Journal of Cell Biology

274

118

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Local differentiations within the endothelium of both muscular (diaphragm, myocardium) and visceral (pancreas, jejunal villi) capillaries have been studied in rats on sectioned and freeze-cleaved preparations . Four distinct parts have been recognized in the endothelial cells of all these vessels on the basis of subcellular components present in each part and on the basis of variations in the local frequency of plasmalemmal vesicles : (a) the parajunctional zone, (b) the peripheral zone, (c) the organelle region, and (d) the nuclear region . Our data indicate that -16, -7 .0, and 8 .5% of the endothelial cytoplasmic volume (in the peripheral zone) is accounted for by vesicles, their content, and their membranes, respectively . The average density of vesicular openings per µm 2 is 78 in diaphragm, 89 in myocardium, 25 in pancreas, and 10 in jejunal mucosa capillaries . The frequency of fenestrae is 1 .7 times as high in jejunal (26/µm 2) as in pancreatic capillaries (15/µm2), the corresponding fractional areas being -9 .5 and -6 0/,, respectively, of the endothelial surface . Intercellular spaces occupy a relatively small area (-0 .08 to 0 .2%) of the inner endothelial surface .

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Section: Introductionmentioning

confidence: 99%

Morphometric Data on the Endothelium of Blood Capillaries

Simionescu

Simiónescu

Palade

1974

The Journal of Cell Biology

274

118

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“…In the freeze-etched preparation, the depressions strongly resemble nuclear pores (Fig . 6) or capillary fenestrae (9,10) . This resemblance is also apparent in well oriented thin sections (Figs.…”

Section: Resultsmentioning

confidence: 99%

Fenestrae in the Rough Endoplasmic Reticulum of the Exocrine Pancreatic Cells

Orci

Perrelet

1972

The Journal of Cell Biology

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“…Fenestrated capillaries of several organs have been examined using this method by FRIEDERICI (1968, 1969), MAUI. (1971), SIMIONESCU et al (1974), FUJITA et al (1975), ISHIMURA et al (1976 and YAMAMOTO et al (1976).…”

Section: Discussionmentioning

confidence: 99%