The trends of assisted reproductive technologies and cost for ovarian stimulation protocols in Ukraine

Zaliska, O.; Stasiv, К.-О. Ya.; Maksymovych, N.; Hrynkiv, Ya. O.

doi:10.3897/pharmacia.67.e55159

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…According to international data, about eight million children have been born globally after the birth of the first child Louise Brown in 1978 via ART [13]. The association between MC/DA twin gestation and CHDs has important clinical implications because the number of twin gestations is steadily rising in the United States partly because of the increased use of assisted reproductive technologies.…”

Section: Review Epidemiologymentioning

confidence: 99%

Epidemiology, Genetics and Epigenetics of Congenital Heart Diseases in Twins

Balasubramanian¹,

Vuppalapati²,

Avanthika³

et al. 2021

Cureus

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Section: Review Epidemiologymentioning

confidence: 99%

Epidemiology, Genetics and Epigenetics of Congenital Heart Diseases in Twins

Balasubramanian¹,

Vuppalapati²,

Avanthika³

et al. 2021

Cureus

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“…На сьогодні близько 15-20% сімейних пар потребують допомоги репродуктологів для настання бажаної вагітності [2]. В Україні з 2000 р. до 2018 р. кількість циклів ДРТ у розрахунку на 1 млн населення зросла з 226,9 до 655,3 циклів [3].…”

Section: особенности течения беременности родов и послеродового перио...unclassified

Features of pregnancy, delivery and postpartum on the background of assisted reproductive technologies

Golyanovskiy

Zukin

Shemyakina

et al. 2021

RHW

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The objective: to establish the characteristics of the course of pregnancy and childbirth after the use of assisted reproductive technologies (ART); to stratify the risks in this contingent of pregnant women, to determine the high-risk subgroup among pregnant women after the use of ART and the formation of possible preventive approaches for these categories of patients. Materials and methods. A retrospective analysis of 3450 histories of pregnancy and childbirth that occurred during 2018–2020, was carried out. Inclusion criteria: first singleton delivery in cephalic presentation without critical congenital malformations in the fetus and severe somatic pathologies in pregnant women aged 18–45 years. Two groups were formed: a group with spontaneous pregnancy (3137 histories) and a group with pregnancy after ART (313 histories), which, according to the age factor, were divided into subgroups of active (2686 and 159 histories, respectively) and late reproductive age (451 and 154 histories, respectively).For statistical analysis, odds ratio (OR) and 95% confidence interval (CI) were calculated. The χ-square test was used to assess the significance of the difference in proportions. The level of statistical significance was at p<0.05.Results. The frequency of normal births in the subgroup of late reproductive age with pregnancy after the use of ART was 38.8%, that almost 2 times lower than in the subgroup of spontaneous pregnancy in women of late reproductive age (65.5%; p<0.05). Patients with late reproductive age and pregnancy after using ART (28.5%) had two times higher chances of induction of labor compared with the spontaneous pregnancy subgroup (14.3%; p<0.05). The incidence of cesarean section was 51.1% in the ART subgroup compared to 27% in the spontaneous pregnancy subgroup (p<0.05). In the subgroup of late reproductive age and pregnancy after ART, the probability of cesarean section was in 1.7 times higher than in the subgroup of active reproductive age and pregnancy after ART. The risks of developing massive obstetric bleeding in patients with late reproductive age and pregnancy after ART were in 5.5 times higher than in patients with spontaneous pregnancy (p<0.05) and 2.8 times higher than in patients of active reproductive age and pregnancy after ART. The rate of normal induced labor in the ART group in women under 35 years of age was 51.7%, while in the subgroup of late reproductive age patients with pregnancy after ART, this indicator decreased to 23.5%. The incidence of unsuccessful induction of labor in patients with late reproductive age and pregnancy after ART was 19.6%, the frequency of cesarean section after induced labor in the subgroup of late reproductive age and pregnancy after ART was 70.6%. The likelihood of the massive obstetric bleeding development during induced labor in patients with late reproductive age and pregnancy after ART was in 5 times higher than in spontaneous pregnancy in this age subgroup (OR 5.05; 95% CI: 0.94-27.05) and 6.8 times higher than in the subgroup of active reproductive age after the use of ART (OR 6.84; 95% CI: 2.2-21.24). The newborns conceived after ART and after induced labor had in 2.8 times greater risks of the necessity for primary neonatal resuscitation.Conclusions. The pregnancy and labor after ART were characterized by a higher incidence of preterm birth, caesarean section, assisted vaginal delivery, and massive obstetric bleeding. The rate of complications significantly increased in women of late reproductive age. For patients with pregnancy after the use of ART, it is advisable to conduct labor using continuous cardiotocography monitoring, timely correction of labor abnormalities according to the partogram, the use of modern effective algorithms for the prevention of obstetric bleeding. For the pregnant women of late reproductive age after ART in the absence of spontaneous onset of regular labor, we recommend to consider the possibility of a planned caesarean section at 40–41 weeks of gestation.

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“…Moreover, according to the ESHRE guideline, there was no evidence to show that the removal of OMA lesion larger than 3 cm before ART could improve pregnancy rates [ 34 ]. In addition, ART is not cost-effective, which restricts its availability and affordability [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

What We Have Learned from Animal Models to Understand the Etiology and Pathology of Endometrioma-Related Infertility

Tan

Hung

et al. 2022

Biomedicines

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Endometrioma (OMA) is the most common subtype of endometriosis, in which the endometriotic lesions are implanted in the ovary. Women with OMA are usually associated with infertility, presenting with reduced ovarian reserve, low oocyte quantity and quality, and poor fertility outcomes. However, the underlying pathological mechanisms in OMA-related infertility are still unclear. Due to the limitations and ethical issues of human studies in reproduction, animal models that recapitulate OMA characteristics and its related infertility are critical for mechanistic studies and subsequent drug development, preclinical testing, and clinical trials. This review summarized the investigations of OMA-related infertility based on previous and latest endometrioma models, providing the possible pathogenesis and potential therapeutic targets for further studies.

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The trends of assisted reproductive technologies and cost for ovarian stimulation protocols in Ukraine

Cited by 6 publications

References 13 publications

Epidemiology, Genetics and Epigenetics of Congenital Heart Diseases in Twins

Epidemiology, Genetics and Epigenetics of Congenital Heart Diseases in Twins

Features of pregnancy, delivery and postpartum on the background of assisted reproductive technologies

What We Have Learned from Animal Models to Understand the Etiology and Pathology of Endometrioma-Related Infertility

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