The treatment of rheumatoid arthritis using Chinese medicinal plants: From pharmacology to potential molecular mechanisms

Lü, Shaowa; Wang, Qiushi; Li, Guoyu; Sun, Shuang; Guo, Yuan‐ji; Kuang, Hai‐Xue

doi:10.1016/j.jep.2015.10.010

Cited by 122 publications

(61 citation statements)

References 171 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among them, curcumin (Cur), a yellow compound derived from the plant Curcuma longa Linn , and resveratrol (Res), a white powder found in grapes, red wine, are the most recognized anti-inflammatory drugs. Curcumin can mitigate inflammatory responses of macrophages stimulated by lipopolysaccharide and inhibit a variety of inflammation markers, such as cyclooxygenase, lipoxygenase and nitric oxide synthase in different extent [8]. Resveratrol has potent anti-inflammatory effect via kinds of inflammatory pathways in vitro and in vivo [9].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of combined tetramethylpyrazine, resveratrol and curcumin in vivo

Chen

Liu

Wang

et al. 2017

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundResveratrol and curcumin, as natural flavones products, have good therapeutic effect in acute and chronic inflammation; on the other hand, tetramethylpyrazine (TMP) has angiogenesis and vessel protection effect as well as anti-inflammatory function. In this paper, the anti-inflammatory effect of the tetramethylpyrazine, resveratrol and curcumin (TRC) combination in acute and chronic inflammation was reported in vivo.MethodsThe dose of the combined three natural products was optimized based on the acute paw swelling mouse model with a Uniform Design methodology. The therapeutic effect of TRC combination on chronic inflammation was investigated by using the collagen-induced arthritis (CIA) rat model based upon the following indexes: the volume of paw swelling, arthritis score, serum mediators and histological examination as well as immunohistochemical staining. The levels of alanine aminotransferase (ALT) and aspartate transaminase (AST) in serum were measured and the pathological sections of liver and kidney were analysed. LD50 was measured based on the acute oral toxicity (AOT) standard method.ResultsThe best formulation was the three components combined at the same mass proportion revealed by the Uniform Design methodology. This combination could significantly reduce the paw swelling in acute paw swelling mouse model, could reduce paw swelling and alleviate the damage in joint structural of ankle, cartilages and fibrous tissue in CIA rat model. The dose relationship was clear in both cases. Immunohistochemical staining of ankle tissue revealed that TRC combination was able to inhibit the expression of NF-κB p65 and TNF-α which were closely related to the inflammatory process. Analysis of serum mediators revealed TRC combination could inhibit the production of TNF-α, IL-1β, and IL-6 in the serum. Toxic study revealed this formulation was low toxic, LD50 was larger than 5 g/kg, both the level of ALT and AST and histopathology in the liver and kidney exhibited no distinctions between the TRC combination and the blank group, no mortality occurred at the administered doses of 5 g/kg.ConclusionsThe results showed this formulation could provide a novel potent treatment for acute and chronic inflammation (RA) without side effect like gastric injury occurring in NSAIDs.

show abstract

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of combined tetramethylpyrazine, resveratrol and curcumin in vivo

Chen

Liu

Wang

et al. 2017

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…For instance, in the Indian Ayurveda system of medicine, E. angustifolia is known as an immunomodulator to treat respiratory conditions. Similarly, in the traditional Chinese medicine, E. purpurea is named Song Guo Ju and is prescribed to prevent and treat upper respiratory tract infections (Kumar et al, ; J. Li, Li, & Zhang, ; Lü et al, ; Patwardhan & Gautam, ).…”

Section: The Genus Echinacea In Traditional Medicinementioning

confidence: 99%

Echinacea plants as antioxidant and antibacterial agents: From traditional medicine to biotechnological applications

Sharifi‐Rad

Mnayer

Morais-Braga

et al. 2018

Phytotherapy Research

129

View full text Add to dashboard Cite

The genus Echinacea consists of 11 taxa of herbaceous and perennial flowering plants. In particular, Echinacea purpurea (L.) Moench is widely cultivated all over the United States, Canada, and in Europe, exclusively in Germany, for its beauty and reported medicinal properties. Echinacea extracts have been used traditionally as wound healing to improve the immune system and to treat respiratory symptoms caused by bacterial infections. Echinacea extracts have demonstrated antioxidant and antimicrobial activities, and to be safe. This survey aims at reviewing the medicinal properties of Echinacea species, their cultivation, chemical composition, and the potential uses of these plants as antioxidant and antibacterial agents in foods and in a clinical context. Moreover, the factors affecting the chemical composition of Echinacea spp. are also covered.

show abstract

“…It could decrease the levels of interleukin (IL)-1β, IL-17, tumor necrosis factor (TNF)-α, vascular endothelial cell growth factor (VEGF) and prostaglandin E2 (PGE2). In addition, it could also reduce percentage of CD4 + cells while increase that of CD8 + cells in peripheral blood of rats with inflammatory arthritis (Qi et al, 2014b; Lü et al, 2015). Recently, some researchers have made great efforts to further study the underlying action mechanism of WTD taking advantage of pharmacokinetic (Zheng et al, 2012), metabolomic (Qi et al, 2014b) and systems biology methods (Zhang Y. et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Wu-Tou Decoction in Rheumatoid Arthritis: Integrating Network Pharmacology and In Vivo Pharmacological Evaluation

et al. 2017

View full text Add to dashboard Cite

Purpose: This study aimed to explore underlying action mechanism of Wu-Tou decoction (WTD) in rheumatoid arthritis (RA) through network pharmacology prediction and experimental verification.Methods: Chemical compounds and human target proteins of WTD as well as RA-related human genes were obtained from TCM Database @ Taiwan, PubChem and GenBank, respectively. Subsequently, molecular networks and canonical pathways presumably involved in the treatment of WTD on RA were generated by ingenuity pathway analysis (IPA) software. Furthermore, experimental validation was carried out with MIP-1β-induced U937 cell model and collagen induced arthritis (CIA) rat model.Results: CCR5 signaling pathway in macrophages was shown to be the top one shared signaling pathway associated with both cell immune response and cytokine signaling. In addition, protein kinase C (PKC) δ and p38 in this pathway were treated as target proteins of WTD in RA. In vitro experiments indicated that WTD inhibited MIP-1β-induced production of TNF-α, MIP-1α, and RANTES as well as phosphorylation of CCR5, PKC δ, and p38 in U937 cells. WTD treatment maintained the inhibitory effects on production of TNF-α and RANTES in MIP-1β-induced U937 cells after CCR5 knockdown. In vivo experiments demonstrated that WTD ameliorated symptoms in CIA rats, decreased the levels of IL-1β, IL-2, IL-6, TNF-α, MIP-1α, MIP-2, RANTES, and IP-10 in serum of CIA rats, as well as mRNA levels of MIP-1α, MIP-2, RANTES, and IP-10 in ankle joints of CIA rats. Furthermore, WTD also lowered the phosphorylation levels of CCR5, PKC δ and p38 in both ankle joints and macrophages in ankle joints from CIA rats.Conclusion: It was demonstrated in this research that WTD played a role in inhibiting inflammatory response in RA which was closely connected with the modulation effect of WTD on CCR5 signaling pathway in macrophages.

show abstract

The treatment of rheumatoid arthritis using Chinese medicinal plants: From pharmacology to potential molecular mechanisms

Cited by 122 publications

References 171 publications

Anti-inflammatory effect of combined tetramethylpyrazine, resveratrol and curcumin in vivo

Anti-inflammatory effect of combined tetramethylpyrazine, resveratrol and curcumin in vivo

Echinacea plants as antioxidant and antibacterial agents: From traditional medicine to biotechnological applications

Wu-Tou Decoction in Rheumatoid Arthritis: Integrating Network Pharmacology and In Vivo Pharmacological Evaluation

Contact Info

Product

Resources

About