The Treatment of Pityriasis Rosea with Convalescent Plasma, Gamma Globulin, and Pooled Plasma

SALIN, ROLFE W.

doi:10.1001/archderm.1957.01550230125018

Cited by 17 publications

(10 citation statements)

References 12 publications

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“…The activated B cells in turn could ex ert an influence on T cells [14] to control further viral pathogenesis as well as modu late further B cell expansion. This hypothe sis is consistent with (1) the recovery from PR and the decline in IgD/IgM B cells; (2) shortening the duration of the disease by passive transfer of convalescent y-globulin or plasma from PR [2,5]; (3) decrease in the capacity of the normal lymphocytes to rosette, when the normal PBL were pre treated with convalescent serum from PR. In this regard our preliminary studies sug gest an immune-complex nature of this inhi bitory factor.…”

Section: Discussionsupporting

confidence: 75%

“…On the grounds that clinically PR is similar to common exanthemata with a sud den onset, short evolution, low rate of re currence, possible contagiousness, therapeu- tic value of convalescent serum or -/-globu lin, and the results of tissue culture studies, it is recognized as a disease with a possible infective etiology [2,[5][6][7]. However, in spite of an extensive search, no supportive evidence has been demonstrated to establish a microbial etiology of PR [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Structure and Biological Function of Human IgD

Kermani-Arab¹,

Jl²,

Ga³

1978

Int Arch Allergy Immunol

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The relative frequency of peripheral blood T and B cells and their biological function(s) from a group of patients with pityriasis rosea (PR) was investigated during the acute and convalescent phases of the disease using rosetting, immunofluorescent tests, and in vitro cell culturing with anti-δ and anti-μ antibodies and phytohemagglutinin (PHA). The total number of immunoglobulin (Ig) bearing cells was significantly increased, in conjunction with a slight decrease in the T cell population. Lymphocytes with surface IgD, IgM, or both Ig, accounted for the increase in the B cell population. This increase was transient, since it was only observed during the acute phase of the disease. In spite of the increase in IgD/IgM bearing B cells, the mitogenic responsiveness of B or T lymphocytes to anti-δ, anti-μ, or PHA was similar to the same patients during the convalescent phase, or to normal donors. Similary, the levels of serum IgM, IgD, IgG, IgA and IgE in PR remained constant and at a normal concentration throughout the experimental period. The significance of the transient increase in IgD/IgM bearing cells in the pathogenesis and etiology of PR and its possible impact on the immune system is discussed.

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Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Structure and Biological Function of Human IgD

Kermani-Arab¹,

Jl²,

Ga³

1978

Int Arch Allergy Immunol

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“…Individual case reports, including the patient in this report, have described 29 women who developed pityriasis rosea during pregnancy and have delivered healthy newborns (Table 3) [6,12–14,23,24]. Indeed, the literature shows a ratio of 6:5 with regards to healthy newborns versus newborns with adverse events being delivered to women with gestational pityriasis rosea.…”

Section: Discussionmentioning

confidence: 99%

“…Our review of the literature, including the patient in this report, discovered 54 women who developed pityriasis rosea during their pregnancy (Table 2 [6,14,22] and Table 3 [6,12–14,23,24]). The onset of pityriasis rosea ranged from week 8 of gestation (3 patients: cases 7 and 8 in Table 2 and case 14 in Table 3) to week 32 (1 patient: case 7 in Table 3).…”

Section: Discussionmentioning

confidence: 99%

Pityriasis rosea in pregnancy: report of a spousal occurrence and craniosynostosis in the healthy newborn

Loh

Cohen

2016

Dermatol Pract Concept

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Background:Pityriasis rosea is a papulosquamous disease. It may occur during pregnancy; in this setting, it has occasionally been associated with adverse outcomes.Purpose:A woman who developed pityriasis rosea at the beginning of her eighth week of gestation is described. The outcomes in newborns delivered by pregnant women who developed pityriasis rosea during gestation are summarized.Method:A 28-year-old woman developed pityriasis rosea during her eighth week of pregnancy. Her husband had pityriasis rosea two months earlier. PubMed was searched for the following terms: conjugal, craniosynostosis, newborn, pityriasis, pregnancy, rosea, sagittal, spouse. The papers were reviewed and the references cited were evaluated.Results:Our patient delivered a healthy male infant after 41 weeks of gestation. He had normal weight, height, and Apgar scores. Isolated sagittal craniosynostosis was diagnosed and was successfully treated at nine weeks after birth without complications.Conclusion:Several retrospective studies have investigated the possibility of adverse outcomes in infants born to women who developed pityriasis rosea during pregnancy, such as stillbirth, low gestational weight, hypotonia, and premature delivery. However, there are also reports of healthy newborns in women who have had pityriasis rosea during gestation. Our patient carried the fetus one week post-term and delivered a healthy boy via C-section; isolated sagittal craniosynostosis was later diagnosed and successfully repaired. The occurrence of craniosynostosis in a woman who developed pityriasis rosea during her first trimester of pregnancy may be two coincidental events.

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“…An aberrant form of PR was seen, characterized by the appearance of many disseminated papules in the characteristic distribution, with a shorter clinical course. Early reports of patients who received pooled immunoglobulin (Ig) [5] or convalescent sera [6] were reported to have a shorter rash duration.…”

Section: General Evidencementioning

confidence: 99%

Pityriasis rosea evidence for and against an infectious aetiology

Chuh

Chan

Zawar³

2004

Epidemiol. Infect.

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Pityriasis rosea, first named as such in 1860, probably holds the longest record for an exanthem suspected to be associated with an infection but for which an exact cause has not been found. The distinctly programmed clinical course, the lack of recurrence for most patients, and the presence of temporal case clustering provide the strongest evidence to support an infectious aetiology. Further support comes from seasonal variation and the association with respiratory tract infections, the unfavourable social and economic background of cases, and a history in some cases of contact with patients with pityriasis rosea. The apparent therapeutic efficacy of several treatment modalities does not provide strong evidence for or against an infectious aetiology. The roles of human herpesvirus 7 and to a lesser extent human herpesvirus 6 remain controversial. There exists reasonable evidence that pityriasis rosea is not associated with cytomegalovirus, Epstein-Barr virus, parvovirus B19, picornavirus, influenza and parainfluenza viruses, Legionella spp., Mycoplasma spp. and Chlamydia spp. infections. Evidence is also unsubstantiated as yet for alternative aetiological hypotheses such as autoimmunity, atopy, and genetic predisposition.

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The Treatment of Pityriasis Rosea with Convalescent Plasma, Gamma Globulin, and Pooled Plasma

Cited by 17 publications

References 12 publications

Structure and Biological Function of Human IgD

Structure and Biological Function of Human IgD

Pityriasis rosea in pregnancy: report of a spousal occurrence and craniosynostosis in the healthy newborn

Pityriasis rosea evidence for and against an infectious aetiology

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