The Treatment of in Situ Breast Cancer

Is, Fentiman

doi:10.3109/02841868909092333

Cited by 12 publications

(3 citation statements)

References 28 publications

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“…If the cancer is also categorized as LCIS, medical professionals tend to not recommend radiotherapy since it is generally not thought to be a precursor of invasive cancer [30]. LCIS patients are usually pre-menopausal [31], which explains why the age group “ 26−50” was also identified as influential for treatment decision. For early invasive BC, patients under stages I, IIA, or IIB, ages between 51 and 75, and grade II were found to be more likely to receive BCSR.…”

Section: Discussionmentioning

confidence: 99%

A Bayesian network and heuristic approach for systematic characterization of radiotherapy receipt after breast-conservation surgery

Soto-Ferrari¹,

Prieto²,

Munene³

2017

BMC Med Inform Decis Mak

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BackgroundBreast-conservation surgery with radiotherapy is a treatment highly recommended by the guidelines from the National Comprehensive Cancer Network. However, several variables influence the final receipt of radiotherapy and it might not be administered to breast cancer patients. Our objective is to propose a systematic framework to identify the clinical and non-clinical variables that influence the receipt of unexpected radiotherapy treatment by means of Bayesian networks and a proposed heuristic approach.MethodsWe used cancer registry data of Detroit, San Francisco-Oakland, and Atlanta from years 2007–2012 downloaded from the Surveillance, Epidemiology, and End Results Program. The samples had patients diagnosed with in situ and early invasive cancer with 14 clinical and non-clinical variables. Bayesian networks were fitted to the data of each region and systematically analyzed through the proposed Zoom-in heuristic. A comparative analysis with logistic regressions is also presented.ResultsFor Detroit, patients under stage 0, grade undetermined, histology lobular carcinoma in situ, and age between 26−50 were found more likely to receive breast-conservation surgery without radiotherapy. For stages I, IIA, and IIB patients with age between 51−75, and grade II were found to be more likely to receive breast-conservation surgery with radiotherapy. For San Francisco-Oakland, patients under stage 0, grade undetermined, and age >75 are more likely to receive BCS. For stages I, IIA, and IIB patients with age >75 are more likely to receive breast-conservation surgery without radiotherapy. For Atlanta, patients under stage 0, grade undetermined, year 2011, and primary site C509 are more likely to receive breast-conservation surgery without radiotherapy. For stages I, IIA, and IIB patients in year 2011, and grade III are more likely to receive breast-conservation surgery without radiotherapy.ConclusionFor in situ breast cancer and early invasive breast cancer, the results are in accordance with the guidelines and very well demonstrates the usefulness of the Zoom-in heuristic in systematically characterizing a group receiving a treatment. We found a subset of the population from Detroit with ductal carcinoma in situ for which breast-conservation surgery without radiotherapy was received, but potential reasons for this treatment are still unknown.Electronic supplementary materialThe online version of this article (doi:10.1186/s12911-017-0479-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

A Bayesian network and heuristic approach for systematic characterization of radiotherapy receipt after breast-conservation surgery

Soto-Ferrari¹,

Prieto²,

Munene³

2017

BMC Med Inform Decis Mak

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“…Mammographic screening has led to an increase in early-stage breast cancer detection [ 1 ]. Ductal carcinoma in situ (DCIS) is characterised by the presence of abnormal cells in the milk duct of the breast and is considered the earliest form of breast cancer [ 2 ]. DCIS does not spread from its site of origin; therefore, it is non-invasive at the time of detection.…”

Section: Objectivementioning

confidence: 99%

Microarray analysis of ductal carcinoma in situ samples obtained by puncture from surgical resection specimens

et al. 2021

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Objective The incidence of ductal carcinoma in situ (DCIS) is increasing due to more widespread mammographic screening. DCIS, the earliest form of breast cancer, is non-invasive at the time of detection. If DCIS tissues are left undetected or untreated, it can spread to the surrounding breast tissue. Thus, surgical resection is the standard treatment. Understanding the mechanism underlying the non-invasive property of DCIS could lead to more appropriate medical treatments, including nonsurgical options. Data description We conducted a microarray-based genome-wide transcriptome analysis using DCIS specimens obtained by puncture from surgical specimens immediately after surgery.

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“…Giving supplements of polyunsaturated fatty acids to patients with multiple sclerosis has been disappointing, and evidence exists that linoleic acid may increase the incidence or accelerate the growth of malignant tumours in laboratory animals. 2 Given these disappointing findings, what can be done? Supportive treatment; physiotherapy, drugs and occasionally intrathecal phenol for spasticity; drugs and self catherisation for problems with micturition; occupational therapy; physiotherapy to improve walking; and drugs and surgical treatments for tremor all optimise the quality of life.…”

mentioning

confidence: 99%