Microarray analysis of ductal carcinoma in situ samples obtained by puncture from surgical resection specimens

Abstract

Objective The incidence of ductal carcinoma in situ (DCIS) is increasing due to more widespread mammographic screening. DCIS, the earliest form of breast cancer, is non-invasive at the time of detection. If DCIS tissues are left undetected or untreated, it can spread to the surrounding breast tissue. Thus, surgical resection is the standard treatment. Understanding the mechanism underlying the non-invasive property of DCIS could lead to more appropriate medical treatments, including nonsurgical options. Data description We conducted a microarray-based genome-wide transcriptome analysis using DCIS specimens obtained by puncture from surgical specimens immediately after surgery.

MALINC1 an Immune-Related Long Non-Coding RNA Associated with Early-Stage Breast Cancer Progression

“…In silico analysis of MALINC1 expression in early-stage breast cancer datasets obtained from Gene Expression Omnibus (GEO) showed significant upregulation of this transcript in DCIS when compared to normal samples ( p = 0.0004 and p = 0.0335; Figure 1 a) [ 12 , 21 ]. However, non-significant differences were observed in MALINC1 expression levels when DCIS and invasive ductal carcinoma (IDC) samples were compared ( p = 0.619; Figure 1 a) [ 22 ].…”

“… MALINC1 expression in normal, pre-invasive, and invasive breast samples. ( a ) In silico analysis of MALINC1 expression among normal, DCIS, and IDC samples obtained from three independent GEO datasets [ 12 , 21 , 22 ]. MALINC1 expression (represented in log2 count per million (CPM) or log2 robust multi-array average values (RMA)) was significantly upregulated in DCIS samples compared with normal samples ( p = 0.0004 and p = 0.0335), whereas non-significant differences were observed between DCIS and IDC cases ( p = 0.619).…”