The Treatment of Diffuse Dermal Angiomatosis of the Breast With Reduction Mammaplasty

Diffuse dermal angiomatosis of the breast: Clinicopathologic study of 5 patients

“…12 Breast involvement has been thought rare; however, our review of the literature identified breast involvement in 5 of 14 previously reported cases. 2,7,8,10,11 DDA is usually bilateral, most commonly affecting large pendulous breasts, as in our 5 patients. The addition of our cases makes the breast the most common location (10 of 19 reported cases).…”

“…Another case of iatrogenic DDA was secondary to placement of an arteriovenous fistula. 1 J AM ACAD DERMATOL VOLUME 71, NUMBER 6 Smoking and DDA are strongly associated, with patients often having a long-standing smoking history, 5,7,8,10 as in 3 of our patients. Hypertension is also associated with DDA.…”

“…2 For the other 3 cases, a cause was not determined. 7,8,10 However, all 3 had large pendulous breasts, and consideration was given to the possible role of local tissue ischemia and trauma.…”

“…2 Since it was first described in 1994 by Krell et al, 3 only 14 cases have been reported worldwide in the medical literature. 1,2,[4][5][6][7][8][9][10][11][12] The clinical presentation of patients varies, with skin conditions ranging from erythematous to violaceous patches and indurated plaques that may ulcerate; these are usually quite tender. Characteristic histopathologic findings include diffuse extravascular benign endothelial cells throughout the dermis that are both CD31 1 and CD34 1 .…”

“…The extremities have been thought to be most commonly involved; however, we identified 5 cases involving the breasts that have been reported. 2,7,8,10,11 We present an additional 5 women with DDA of the breast and review the existing literature.…”