Diffuse dermal angiomatosis of the breast: Clinicopathologic study of 5 patients

Tollefson, Megha M.; McEvoy, Marian T.; Torgerson, Rochelle R.; Bridges, Alina G.

doi:10.1016/j.jaad.2014.08.015

Cited by 28 publications

(51 citation statements)

References 12 publications

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“…Therefore, the imaging tests and histologic morphology should be combined for an accurate diagnosis. The differential diagnosis of low‐grade angiosarcoma includes a number of benign vascular lesions, including perilobular hemangiomas, cavernous and capillary hemangiomas , papillary endothelial hyperplasia (PEH) , and diffuse dermal angiomatosis . In addition to the size, the key point in the distinction of hemangiomas and PEH is the growth of the lesion.…”

Section: Discussionmentioning

confidence: 99%

“…Most hemangiomas and PEH were well circumscribed, with no involvement of the breast parenchyma. Although diffuse dermal angiomatosis shows a diffuse proliferation of vessels between the collagen bundles throughout the dermis, the vessels are regular with no complex anastomosing channels and grow in a nondestructive manner . Another possible benign process that may cause a diagnostic pitfall is pseudoangiomatous stromal hyperplasia (PASH).…”

Section: Discussionmentioning

confidence: 99%

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Primary Breast Angiosarcoma: A Retrospective Study of 36 Cases from a Single Chinese Medical Institute with Clinicopathologic and Radiologic Correlations

Wang

Lao

et al. 2016

Breast J

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The aim of this study was to present our experience with primary breast angiosarcoma (PBA) by describing a large series of cases with an emphasis on clinicopathologic and radiologic correlations. Thirty-six cases of PBA diagnosed at our institution between 2006 and 2014 were retrospectively evaluated. All but one case occurred in women with a median age of 35.5 years. The majority of patients presented with a deeply located painless mass, whereas a minority manifested as diffuse enlargement or swelling of the breast. Magnetic resonance imaging showed poorly demarcated lesions with low signal intensity on T1-weighted images, markedly high intensity on T2-weighted images, and prolongation of enhancement upon dynamic study. Histologically, 19 cases (52.8%) were low grade, 12 cases (33.3%) were intermediate grade, and 5 cases (13.9%) were high grade. Follow-up information was available for 27 patients and revealed local recurrence and/or metastasis in 16 patients (59.3%). Five patients (18.5%) died of the disease at a median interval of 20 months. Univariate analysis showed that tumor differentiation had effect on disease-free survival (DFS) (p = 0.005) but failed to predict overall survival (OS) (p = 0.645). The treatment modality was related to OS (p = 0.042) but not DFS (p = 0.131). The Cox proportional hazards regression model suggested that tumor differentiation was an independent predictor of DFS (p = 0.015). We hypothesize that tumor differentiation may be used as a prognostic factor for this rare malignancy. Clinicopathologic and radiologic correlation may help pathologists to arrive at the correct diagnosis of PBA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary Breast Angiosarcoma: A Retrospective Study of 36 Cases from a Single Chinese Medical Institute with Clinicopathologic and Radiologic Correlations

Wang

Lao

et al. 2016

Breast J

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“…However, diffuse dermal angiomatosis is a unique variant of RAE, which is characterized by diffuse extravascular endothelial cells proliferating throughout the dermis . Proliferative cells stain positive for CD31 and CD34 . No specific treatment is available, and it is managed by treating the underlying systemic disorder.…”

Section: Discussionmentioning

confidence: 99%

Recurrent reactive angioendotheliomatosis in pregnancy: a case report

et al. 2015

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“…Diffuse dermal angiomatosis (DDA) is pathologically distinct subtype of cutaneous reactive angioendotheliomatosis that often involves the breast . In total, 37 cases of DDA of the breast have been described with only 26 biopsy‐confirmed cases . Reported risk factors include pendulous macromastia, vaso‐occlusion, smoking, and vasculitis among others .…”

Section: Introductionmentioning

confidence: 99%

“…In total, 37 cases of DDA of the breast have been described with only 26 biopsy‐confirmed cases . Reported risk factors include pendulous macromastia, vaso‐occlusion, smoking, and vasculitis among others . Clinically, DDA manifests as violaceous, flat‐to‐indurated, puckered and tender plaques, some with ulceration .…”

Section: Introductionmentioning

confidence: 99%

Diffuse dermal angiomatosis mimicking inflammatory breast carcinoma

et al. 2017

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Diffuse dermal angiomatosis (DDA) is a rare pathologically distinct subtype of reactive angioendotheliomatosis. In the literature, few biopsy-proven cases involving breast skin have been reported. We present a case of a 49-year-old female who presented with an indurated, erythematous, weeping, puckered and tender lesion with focal ulceration. Mammography demonstrated diffuse cutaneous and trabecular thickening concerning for inflammatory breast carcinoma. A punch biopsy demonstrated findings consistent with DDA. To our knowledge, this is the first reported case of DDA mimicking inflammatory carcinoma of the breast by clinical and radiologic examination.

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Diffuse dermal angiomatosis of the breast: Clinicopathologic study of 5 patients

Cited by 28 publications

References 12 publications

Primary Breast Angiosarcoma: A Retrospective Study of 36 Cases from a Single Chinese Medical Institute with Clinicopathologic and Radiologic Correlations

Primary Breast Angiosarcoma: A Retrospective Study of 36 Cases from a Single Chinese Medical Institute with Clinicopathologic and Radiologic Correlations

Recurrent reactive angioendotheliomatosis in pregnancy: a case report

Diffuse dermal angiomatosis mimicking inflammatory breast carcinoma

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