The Treatment of Dermatological Infections With a Manganese Phenanthroline Chelate: A Controlled Clinical Trial

Synthesis and antimicrobial activity of a phenanthroline-isoniazid hybrid ligand and its Ag+ and Mn2+ complexes

“…Since the 1950s, metal-free ligands and coordination complexes constituted by members of the 1,10phenanthroline family of N,N'-chelating ligands have been shown to inhibit the growth of potentially harmful microorganisms (MacLeod 1952;Dwyer et al 1957Dwyer et al , 1969aShulman and Dwyer 1964;Butler et al 1969Butler et al , 1970Cade et al 1970;McCann et al 2012a, b;Viganor et al 2017;McCarron et al 2018). Dwyer et al (1969a, b) formulated and patented phenanthroline-containing therapeutics for topical application to humans, lower animals and plants in order to combat diseases induced by a wide variety of organisms.…”

“…Dwyer et al (1969a, b) formulated and patented phenanthroline-containing therapeutics for topical application to humans, lower animals and plants in order to combat diseases induced by a wide variety of organisms. In 1970 in Melbourne, Australia, the results of two controlled clinical trials (Cade et al 1970;Bulter et al 1970) on patients suffering from topical infections due to fungi, bacteria and protozoa showed the highly beneficial effects of the topical application of formulations containing Mn 2? , Cu 2?…”

“…Additionally, the metal complexes were non-toxic and it was reported in the trial involving the Mn 2? complexes (Cade et al 1970) that microbial resistance did not develop.…”