Medicinal chemistry

Perrin, D. D.

doi:10.1007/bfb0045700

Cited by 19 publications

(1 citation statement)

References 133 publications

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“…The resulting mixed ligand complex is also neutral and antibacterial. The cobalt(II)-EDTA chelate can combine with cyanide, and, in fact, the mixed complex has been recommended and used as an antidote cyanide poisoning (16).…”

Section: Lipophilicity and Intracellular Transportmentioning

confidence: 99%

Chelating agents in biological systems.

Schubert¹

1981

Environ Health Perspect

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Chelation enables metals to be transported to or from vulnerable target sites, and to hinder or facilitate their carcinogenic potential. In the reverse sense, metals are capable of ligand scavenging via complexation or mixed complex formation-the latter being the result of interaction with binary complexes. Consequently, metal complexes can be utilized for the transport of selected organic chemotherapeutic drugs to target organs, or for the decorporation of those toxic organic compounds which are able, before or after metabolic activation, of reacting with metals or 1:1 metal complexes. It is emphasized that the degree to which metal ions interact in vivo should employ the conditional constants which take into account competition from other ions, especially Ca2 +, H +, and OH-. The genotoxic consequences ofthe various chemical factors involved in chelation, along with examples: kinetics, stabilization of oxidation states, lipophilicity, and mixed ligand formation, are discussed.

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Section: Lipophilicity and Intracellular Transportmentioning

confidence: 99%

Chelating agents in biological systems.

Schubert¹

1981

Environ Health Perspect

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Simultaneous determination of polyamines and catecholamines in PC‐12 tumor cell extracts by capillary electrophoresis with laser‐induced fluorescence detection

Flanigan

2004

Electrophoresis

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A method to detect polyamines and catecholamines in PC-12 tumor cell extracts by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) is described for the first time. Both derivatization conditions and buffer concentrations and pH were optimized. Under optimized conditions the polyamines (putresine, spermine, spermidine) and catecholamines (dopamine, norepinephrine, epinephrine, serotonin) were derivatized with fluorescein isothiocyanate and separated at 25 kV in a fused-silica capillary (50 microm ID x 40 cm) with 0.1 M borate, pH 9.0, in less than 18 min. The influence of running buffer conditions, such as buffer pH and concentrations, were also investigated. Linearity of the analytes ranged from 0.05 to 1.0 micromol/L, and the detection limit (S/N = 3 ) ranged from 0.03 to 2.50 nmol/L. The concentrations of polyamines and catecholamines in PC-12 tumor cell extracts were determined with this method.

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