The Treatment of Deep Vein Thrombosis With Continuous Intravenous Low-Molecular-Weight Dermatan Sulphate (Desmin). A Pilot Study

Jg, Kretz; Chakfé, Nabil; Wiesel, Marie Luise; Grunebaum, Lélia; Zamboni, V.; Palazzini, E; Cazenave, J.‐P.

doi:10.1016/s0049-3848(96)00207-1

Cited by 8 publications

(3 citation statements)

References 27 publications

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“…Studies on dermatan sulfate and LMW dermatan sulfate (Desmin), which act via heparin cofactor II (HCII), have shown that these compounds are powerful inhibitors of thrombus formation (3,4,16,17). Desmin has a weak anticoagulant effect and does not induce bleeding complications.…”

Section: Discussionmentioning

confidence: 99%

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Antithrombotic and Anticoagulant Activities of a Low Molecular Weight Fucoidan by the Subcutaneous Route

Millet

Jouault²,

Mauray³

et al. 1999

Thromb Haemost

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SummaryFucoidans (high-molecular-weight sulfated polysaccharides extracted from brown seaweeds) have anticoagulant and antithrombotic effects. They inhibit thrombin by catalyzing both serpins (antithrombin and heparin cofactor II) according to their chemical structures and origins. In this study, a low-molecular-weight (LMW) fucoidan of 8 kDa was obtained by chemical degradation of a high-molecular-weight fraction. The antithrombotic and anticoagulant activities of this new compound were compared to those of a low-molecular-weight heparin (LMWH), dalteparin, following subcutaneous administration to rabbits. This LMW fucoidan exhibited dose-related venous antithrombotic activity, with an ED80 of about 20 mg/kg, 2 h after a single subcutaneous injection. Its activity was comparable to that of dalteparin (close to 200 anti-Xa IU/kg) and was maximal 30 min after a single subcutaneous injection. The activity remained stable (about 70%) from 1 to 4 h after injection, but disappeared by 8 h. The antithrombotic activity was not associated with either a prolongation of the thrombin clotting time (TCT) or an increase in anti-Xa activity, contrary to dalteparin. A slight prolongation of APTT occurred with both compounds. This venous antithrombotic activity was associated with a decrease in ex vivo thrombin generation and with a significant increase in the lag phase in a thrombin generation test. LMW fucoidan thus has potent antithrombotic activity and a potentially weaker haemorrhagic effect (i.e. a smaller effect on coagulation tests and a smaller prolongation of the bleeding time) than dalteparin.

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Section: Discussionmentioning

confidence: 99%

“…More recently, a new low-molecular-weight dermatan sulfate with better bioavailability than high-molecular-weight dermatan sulfate was also found to be a potent antithrombotic agent in animals after subcutaneous administration (3). In a pilot study, this compound was active in the treatment of deep venous thrombosis (4).…”

Section: Introductionmentioning

confidence: 99%

Antithrombotic and Anticoagulant Activities of a Low Molecular Weight Fucoidan by the Subcutaneous Route

Millet

Jouault²,

Mauray³

et al. 1999

Thromb Haemost

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show abstract

“…bolus followed by continous infusion, has been clinically tested in pilot studies on the treatment of VTE (Kretz et al [27]; Venosi et al [28]; von Kemp et al [29]). No adverse effects were observed in the three studies.…”

Section: Clinical Efficacy and Safetymentioning

confidence: 99%

Dermatan Sulphate as an Antithrombotic Drug

Nenci

2002

Pathophysiol Haemos Thromb

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Extraction, purification and characterisation of dermatan sulphate from bovine collagen waste liquor

Osborne

Daniel

Chen

et al. 2016

Food and Bioproducts Processing

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The Treatment of Deep Vein Thrombosis With Continuous Intravenous Low-Molecular-Weight Dermatan Sulphate (Desmin). A Pilot Study

Cited by 8 publications

References 27 publications

Antithrombotic and Anticoagulant Activities of a Low Molecular Weight Fucoidan by the Subcutaneous Route

Antithrombotic and Anticoagulant Activities of a Low Molecular Weight Fucoidan by the Subcutaneous Route

Dermatan Sulphate as an Antithrombotic Drug

Extraction, purification and characterisation of dermatan sulphate from bovine collagen waste liquor

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