The TREAT Asia HIV Observational Database

Zhou, Jialun; Kumarasamy, N.; Ditangco, Rossana; Kamarulzaman, Adeeba; Lee, Christopher K.C.; Li, Patrick C K; Paton, Nicholas I.; Phanuphak, Praphan; Pujari, Sanjay; Vibhagool, Asda; Wong, Wing‐Wai; Zhang, Fujie; Chuah, John; Frost, Kevin R.; Cooper, David A.; Law, Matthew

doi:10.1097/01.qai.0000145351.96815.d5

Cited by 137 publications

(153 citation statements)

References 13 publications

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“…A detailed description of this collaboration has been published previously. 26 Data for both cohorts are transferred electronically to the Kirby Institute every March and September and include the same set of core variables, including: All data are subject to standardized quality control procedures.…”

Section: Study Populationmentioning

confidence: 99%

Antiretroviral Treatment Interruption and Loss to Follow-Up in Two HIV Cohorts in Australia and Asia: Implications for ‘Test and Treat’ Prevention Strategy

Guy

WandHandan

McManus

et al. 2013

AIDS Patient Care and STDs

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Both antiretroviral treatment interruption (TI) and cessation have been strongly discouraged since 2006. We describe the incidence, duration, and risk factors for TI and loss-to-follow-up (LTFU) rates across 13 countries. and ART with food restrictions (fasting or with food). In conclusion, since 2006, 7.8% of patients had significant time off treatment, which has the potential to compromise any 'test and treat' policy as during the interruption viral load will rebound and increase the risk of transmission.

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Section: Study Populationmentioning

confidence: 99%

Antiretroviral Treatment Interruption and Loss to Follow-Up in Two HIV Cohorts in Australia and Asia: Implications for ‘Test and Treat’ Prevention Strategy

Guy

WandHandan

McManus

et al. 2013

AIDS Patient Care and STDs

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“…30,31 Overall, the effects of other adjusted characteristics in the regression models are consistent with previous findings. 4,12,16,32,33 Age and CD4 count were both significantly associated with the three treatment outcomes. Older age showed an association with lower CD4 increase and an increased risk of mortality.…”

Section: Ten Years Of Cart In Tahod 777mentioning

confidence: 92%

“…3 The TREAT Asia program of amfAR (The Foundation for AIDS Research), established the TREAT Asia HIV Observational Database (TAHOD) in 2003, aimed at evaluating the impact of HIV disease, coinfections, and cART management on clinical outcomes in the Asia-Pacific, to inform HIV care and treatment practices and policies in the region. TAHOD 4 is a prospective observational database and adult cohort study that has collected data from 23 sites in 13 countries and territories in Asia. All TAHOD sites are major referral centers in urban cities.…”

Section: Introductionmentioning

confidence: 99%

A Decade of Combination Antiretroviral Treatment in Asia: The TREAT Asia HIV Observational Database Cohort

Jiamsakul¹

2016

AIDS Research and Human Retroviruses

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Asian countries have seen the expansion of combination antiretroviral therapy (cART) over the past decade. The TREAT Asia HIV Observational Database (TAHOD) was established in 2003 comprising 23 urban referral sites in 13 countries across the region. We examined trends in treatment outcomes in patients who initiated cART between 2003 and 2013. Time of cART initiation was grouped into three periods: 2003-2005, 2006-2009, and 2010-2013. We analyzed trends in undetectable viral load (VL; defined as VL <400 copies/ml), CD4 changes from pre-cART levels, and overall survival. Of 6,521 patients included, the overall median CD4 count at cART initiation was 120 cells/ll (interquartile range: 38-218). Despite an increase over time, pre-cART CD4 counts remained <200 cells/ll. Adjusted analyses showed undetectable VL was more likely when starting cART in later years [2006-2009: No differences in CD4 response was observed over time. Age and CD4 levels prior to cART initiation were associated with all three treatment outcomes, with older age and higher CD4 counts being associated with undetectable VL. Survival and VL response on cART have improved over the past decade in TAHOD, although CD4 count at cART initiation remained low. Greater effort should be made to facilitate earlier HIV diagnosis and linkage to care and treatment, to achieve greater improvements in treatment outcomes.

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“…Viral genotyping using Sanger sequencing is now integrated into HIV patient care in the developed world and aids the determination of treatment regimens for new patients as well as patients failing treatment [1][2][3]. Global databases of HIV sequences have been established [4][5][6] and serve to monitor the global diversity of viral genotypes, provide a reference for sequence interpretation, and catalyze discoveries related to sequence evolution and genotype-phenotype associations. In our own work we have used these databases to study the impact of different genetic backgrounds on the evolution of HIV-1 drug resistance [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

QColors: An algorithm for conservative viral quasispecies reconstruction from short and non-contiguous next generation sequencing reads

Huang

Kantor

DeLong

et al. 2011

2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)

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Next generation sequencing technologies have recently been applied to characterize mutational spectra of the heterogeneous population of viral genotypes (known as a quasispecies) within HIVinfected patients. Such information is clinically relevant because minority genetic subpopulations of HIV within patients enable viral escape from selection pressures such as the immune response and antiretroviral therapy. However, methods for quasispecies sequence reconstruction from next generation sequencing reads are not yet widely used and remains an emerging area of research. Furthermore, the majority of research methodology in HIV has focused on 454 sequencing, while many next-generation sequencing platforms used in practice are limited to shorter read lengths relative to 454 sequencing. Little work has been done in determining how best to address the read length limitations of other platforms.The approach described here incorporates graph representations of both read differences and read overlap to conservatively determine the regions of the sequence with sufficient variability to separate quasispecies sequences. Within these tractable regions of quasispecies inference, we use constraint programming to solve for an optimal quasispecies subsequence determination via vertex coloring of the conflict graph, a representation which also lends itself to data with non-contiguous reads such as paired-end sequencing. We demonstrate the utility of the method by applying it to simulations based on actual intra-patient clonal HIV-1 sequencing data.

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The TREAT Asia HIV Observational Database

Abstract: Analyses of retrospective data in the TAHOD suggest that the overall response to HAART in Asian populations is similar to that seen in Western countries.

Cited by 137 publications

References 13 publications

Antiretroviral Treatment Interruption and Loss to Follow-Up in Two HIV Cohorts in Australia and Asia: Implications for ‘Test and Treat’ Prevention Strategy

Antiretroviral Treatment Interruption and Loss to Follow-Up in Two HIV Cohorts in Australia and Asia: Implications for ‘Test and Treat’ Prevention Strategy

A Decade of Combination Antiretroviral Treatment in Asia: The TREAT Asia HIV Observational Database Cohort

QColors: An algorithm for conservative viral quasispecies reconstruction from short and non-contiguous next generation sequencing reads

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