The transported active mulberry leaf phenolics inhibited adipogenesis through
            <i>PPAR‐γ</i>
            and
            <i>Leptin</i>
            signaling pathway

Li, Qian; Pang, Daorui; Li, Erna; Liu, Tong‐Xian; Liu, Fan; Zou, Yonggen

doi:10.1111/jfbc.14270

Cited by 9 publications

(5 citation statements)

References 50 publications

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“…Reducing backfat is key to improving the lean meat percentage, relevant studies have found that mulberry leaves can inhibit the deposition of backfat by promoting the secretion of leptin and the expression of the lipolysis gene HSL in the backfat tissue of pigs and inhibiting the expression of the fatty acid synthesis gene FASN, which is consistent with our results [16]. Leptin, a cytokine secreted by adipocytes, can promote lipolysis and inhibit fat deposition, which may be related to the regulation of backfat by mulberry leaves [26]. In addition, mulberry leaves may regulate fat deposition through the de novo fatty acid synthesis (DNL) pathway.…”

Section: Discussionsupporting

confidence: 91%

Comprehensive multi-omics analysis revealed that mulberry leaf dietary supplementation can improve the lipo-nutritional quality of pork and regulate gut microbiota in pigs

Hou,

Ji,

Chu

et al. 2023

Preprint

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Results showed that mulberry leaves could significantly reduce backfat thickness (P&lt;0.05) and increase intramuscular fat (IMF) content (P&lt;0.05). Lipidomics analysis showed that mulberry leaves improved lipid profile composition and increased the proportion of triglycerides (TG). Interestingly, IMF content was positively correlated with acyl C18:2 and negatively correlated with C18:1 of differential TGs. In addition, cecal microbiological analysis showed that mulberry leaves could increase the abundance of bacteria such as UCG−005, Muribaculaceae_norank, Prevotellaceae_NK3B31_group, Limosilactobacillus, and so on. At the same time improve the L-tyrosine-baton rouge ester, Oleic acid methyl ester, 21-deoxycortisol, N-acetyldihydrosphingosine, Mulberrin relative abundance. In this study, we found that mulberry leaves could extremely significantly increasing the mRNA relative expression of lipoprotein lipase (LPL), fatty acid-binding protein 4 (FABP4) and peroxisome proliferators-activated receptor γ (PPARγ) in muscle (P＜0.01), significantly increasing mRNA relative expression of diacylglycerol acyltransferase 1 (DGAT1) (P＜0.05) and significantly decreasing the mRNA relative expression of acetyl CoA carboxylase (ACC) (P＜0.05), and aignificantly upregulated hormone-sensitive triglyceride lipase (HSL), peroxisome proliferators-activated receptor α (PPARα) mRNA relative expression (P＜0.05) in backfat. In addition mulberry leaves could increased serum leptin and adiponectin (P＜0.01). Ultimately lead to up-regulation of IMF and down-regulation of backfat.

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Section: Discussionsupporting

confidence: 91%

Comprehensive multi-omics analysis revealed that mulberry leaf dietary supplementation can improve the lipo-nutritional quality of pork and regulate gut microbiota in pigs

Hou,

Ji,

Chu

et al. 2023

Preprint

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show abstract

“…7 Kaempferol-3-O-rutinoside, quercetin, morin, coumaric acid, gallic acid, caffeic acid, ferulic acid, and polysaccharides are also present in ML. [8][9][10][11] The bioactive components in ML are mainly divided into flavonoids, [12][13][14] phenolics, 13,15,16 phytosterols, 17,18 terpenes, 17,18 γ-aminobutyric acid, 19,20 alkaloids, [21][22][23] and polysaccharides. [23][24][25][26] 1-DNJ is one of the primary alkaloids in ML, and it is an inhibitor of α-glucosidase, which results in the inhibition of the elevation of postprandial blood glucose.…”

Section: Introductionmentioning

confidence: 99%

Effect of mulberry leaf or mulberry leaf extract on glycemic traits: a systematic review and meta-analysis

et al. 2023

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“…A total of 16 flavonoids were identified in MLs, including rutin ( Ceymann et al, 2011 ) (1), quercetin ( Lee et al, 2012 ) (2), kaempferol ( Li Q et al, 2022 ), luteolin (4), cymaroside ( Yang et al, 2019 ) (5), kaempferol-3-o-rutinoside ( Vieira et al, 2017 ) (6), hyperoside (7), isoquercetin (8), quercitrin (9), astragalin (10), morin (11), moracin O (12), moracin M (13), kuwanon C (14), isobavachalcone (15), and sakuranetin (16).…”

Section: Resultsmentioning

confidence: 99%

Therapeutic mechanisms of mulberry leaves in type 2 diabetes based on metabolomics

Zhao

et al. 2022

Front. Pharmacol.

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Background: Type 2 diabetes (T2D) is considered as one of the most significant metabolic syndromes worldwide, and the long-term use of the drugs already on the market for T2D often gives rise to some side effects. The mulberry leaf (ML), Morus alba L., has advantages in terms of its comprehensive therapeutic efficacy, which are characterized as multicomponent, multitarget, multipathway, and matching with the complex pathological mechanisms of diabetes.Methods: T2D rats were established by a high-fat diet combined with an intraperitoneal injection of streptozotocin; an evaluation of the hypoglycemic effects of the ML in combination with fasting blood glucose and other indicators, in addition to the utilization of metabolomics technology, was performed to analysis the metabolite changes in serum of rats.Results: MLs significantly reduced the fasting blood glucose of T2D rats, while improving the symptoms of polyphagia and polyuria. ML treatment altered the levels of various metabolites in the serum of T2D rats, which are involved in multiple metabolic pathways (amino acid metabolism, carbohydrate metabolism, and lipid metabolism), played a role in antioxidative stress and anti-inflammation, modulated immune and gluconeogenesis processes, and improved obesity as well as insulin resistance (IR).Conclusion: The ML contains a variety of chemical components, and metabolomic results have shown that MLs regulate multiple metabolic pathways to exert hypoglycemic effects, suggesting that MLs may have great promise in the development of new hypoglycemic drugs.

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The transported active mulberry leaf phenolics inhibited adipogenesis through PPAR‐γ and Leptin signaling pathway

Cited by 9 publications

References 50 publications

Comprehensive multi-omics analysis revealed that mulberry leaf dietary supplementation can improve the lipo-nutritional quality of pork and regulate gut microbiota in pigs

Comprehensive multi-omics analysis revealed that mulberry leaf dietary supplementation can improve the lipo-nutritional quality of pork and regulate gut microbiota in pigs

Effect of mulberry leaf or mulberry leaf extract on glycemic traits: a systematic review and meta-analysis

Therapeutic mechanisms of mulberry leaves in type 2 diabetes based on metabolomics

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