The transport of beryllium in rat blood

Vacher, J; Stoner, H. B.

doi:10.1016/0006-2952(68)90162-7

Cited by 29 publications

(7 citation statements)

References 12 publications

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“…This may be due to tissue lysosomal disruption, phagocytosis and tissue damage. 22,23 Liver damage and an increase in blood lactic acid 2 may result in hypoglycemia because the blood sugar level revealed a significant fall after beryllium intoxication. The reduction in glycogen concentration may be due to disturbances in the carbohydrate metabolism and impairment of key enzymes such as hexokinase, glucokinase, phosphoglucomutase and glucose-6-phosphatase.…”

Section: Discussionmentioning

confidence: 99%

Influence of chelating agents on the toxicity and distribution of beryllium in rats

et al. 1998

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The effect of two new chelating agents—Tiron (4,5‐dihydroxy‐1,3‐benzene disulphonic acid disodium salt) and succinic acid—on the mobilization of beryllium was studied. Animals were exposed to beryllium nitrate (1 mg kg−1 i.p.) daily for 21 days. Administration of beryllium nitrate showed a marked decrease in haemoglobin percentage, blood sugar, serum alkaline phosphatase and serum protein and a significant increase in the activity of transaminases. Tissue protein and glycogen contents and the activity of alkaline phosphatase, adenosine triphosphatase and succinic dehydrogenase showed significantly decreased values, but beryllium nitrate provoked a considerable increase in the activity of acid phosphatase and glucose‐6‐phosphatase in the vital and reproductive organs. Significant improvement in the haematological and biochemical parameters was observed with Tiron but no therapeutic effect was seen with succinic acid. Atomic absorption spectrophotometry (AAS) also showed a decreased level of beryllium concentration in the liver and kidney after Tiron therapy. © 1998 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Influence of chelating agents on the toxicity and distribution of beryllium in rats

et al. 1998

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“…Evidence has been presented that in vivo beryllium concentrates in two cell organelles, the lysosomes and the nucleus. The work of Cheng (1956) and Reeves & Vorwald (1961) suggested that soluble beryllium salts once in the blood form and are transported as colloidal particles of beryllium phosphate and hydroxide, possibly loosely associated with some serum globulins (Vacher & Stoner, 1968). Colloidal metal salts have, by histology or electron microscopy or both, been shown to be present in lysosomes [colloidal iron (Kent, Minick, Volini, Orfei & de la Huerga, 1963;Theron, Hawtrey, Liebenberg & Schirren, 1963); colloidal mercuric sulphide (Oudea, 1963;Hampton, 1958); thorium oxide (Hampton, 1958); copper (Goldfisher, 1965); colloidal gold (Shnitka, 1965); tellurium (Blinzinger & Hager, 1965)].…”

Section: Discussionmentioning

confidence: 99%

Uptake, distribution and binding of beryllium to organelles of the rat liver cell

Witschi

Aldridge

1968

Biochemical Journal

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1. Male rats were injected intravenously with amounts ranging from 0.08 to 111.0mumoles of [(7)Be]beryllium sulphate/kg. body wt. The distribution in the rat and the subcellular distribution of beryllium in the liver were determined. 2. Within the entire dose range a higher specific activity of beryllium was present in a mitochondrial fraction containing the lysosomes. Purification of this fraction confirmed that beryllium is taken up by lysosomes. 3. With doses approaching the LD(50), beryllium was also found in increasing amounts to be present in the liver cell nuclei. Beryllium also showed affinity towards isolated cell nuclei in vitro. Evidence is presented that they have one class of binding sites for beryllium. Mitochondria have less affinity for beryllium. 4. No evidence could be obtained of an affinity of beryllium for DNA or RNA by fractionation of nuclei and dialysis experiments. 5. The presence of beryllium in liver cell nuclei may be relevant to the effects of beryllium on nuclear structure and function.

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“…96 The Be dose level resulting in death for 50% of test animals (LD 50 ) have been determined for several species and routes of exposure. 97,98,99 , 100 , 101 Lung cancers have been caused by Be in test animals in various research projects. 102,103,94,104 Be exposure via ingestion has been studied with mixed results.…”

Section: Beryllium Toxicity Data From Animals Experimentationmentioning

confidence: 99%

Sampling for Beryllium Surface Contamination using Wet, Dry and Alcohol Wipe Sampling

Kerr

2004

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by Kent KerrThis research compared three wipe sampling techniques currently used to test for beryllium contamination on room and equipment surfaces in Department of Energy facilities. Efficiencies of removal of beryllium contamination from typical painted surfaces were tested by wipe sampling without a wetting agent, with water-moistened wipe materials, and by methanol-moistened wipes. Analysis indicated that methanol-moistened wipe sampling removed about twice as much beryllium/oil-film surface contamination as water-moistened wipes, which removed about twice as much residue as dry wipes. As facilities change wipe sampling methods among the three compared in this study, these results may be useful for approximate correlations. Accurate decontamination decision-making depends on the selection of appropriate wetting agents for the types of residues and surfaces. Evidence for beryllium sensitization via skin exposure argues in favor of wipe sampling with wetting agents that provide enhanced removal efficiency such as methanol when surface contamination includes oil mist residue.

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The transport of beryllium in rat blood

Cited by 29 publications

References 12 publications

Influence of chelating agents on the toxicity and distribution of beryllium in rats

Influence of chelating agents on the toxicity and distribution of beryllium in rats

Uptake, distribution and binding of beryllium to organelles of the rat liver cell

Sampling for Beryllium Surface Contamination using Wet, Dry and Alcohol Wipe Sampling

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