The transplacental passage of prednisone and prednisolone in pregnancy near term

Beitins, Inese Z.; Bayard, Françis; Ances, Isadore G.; Kowarski, A. Avinoam; Migeon, Claude J.

doi:10.1016/s0022-3476(72)80547-x

Cited by 245 publications

(92 citation statements)

References 28 publications

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“…Radiolabaled prednisone and prednisolone can cross the placenta, but maternal / cord blood ratios are approximately 10:1 (Beitins 1972). In utero exposure to high-dose steroid and immunosuppressive agents does not seem to be associated with an increased incidence of congenital anomalies in the offspring of pregnant women with a renal transplant.…”

Section: Glucocorticoidsmentioning

confidence: 99%

Sexual and Reproductive Function in Chronic Kidney Disease and Effect of Kidney Transplantation

Lessan‐Pezeshki¹,

Ghazizadeh²

2011

After the Kidney Transplant - The Patients and Their Allograft

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Section: Glucocorticoidsmentioning

confidence: 99%

Sexual and Reproductive Function in Chronic Kidney Disease and Effect of Kidney Transplantation

Lessan‐Pezeshki¹,

Ghazizadeh²

2011

After the Kidney Transplant - The Patients and Their Allograft

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“…Approximately 500 cpm 3 H-F and 3 H-E were added to each plasma sample for recovery purposes. The plasma sample was then extracted with distilled chloroform and paper chromatography performed as described above.…”

Section: Plasma Concentration Of F and Ementioning

confidence: 99%

The Metabolic Clearance Rate, Blood Production, Interconversion and Transplacental Passage of Cortisol and Cortisone in Pregnancy Near Term

et al. 1973

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A constant infusion of 14 C-cortisol and 3 H-cortisone for 4 hr was given to six pregnant women, at term, at the time of elective cesarean section. Radioactive and nonradioactive cortisol (F) and cortisone (E) concentrations were determined in maternal and cord plasma at the time when the concentration of the radioactive steroids had reached a plateau. Metabolic clearance rates (MCR), plasma levels of endogenous F and E, blood production rates (BP), conversion ratios (Cr), and transfer constants ([p] BB values) were calculated and compared with those obtained in eight nonpregnant women, half of whom took contraceptive medication (subjects taking "the pill") and half of whom did not (control subjects).The MCR (F) of women near term, control subjects, and women receiving contraceptive treatment were (mean db SD) 133 ± 47, 141 ± 37, and 62 db 24 liters/24 hr, respectively. The latter was significantly lower than the other two. The MCR (E) were similar in all three groups of subjects and 4-7 times greater than MCR (F).The ratio of the endogenous F/E for control subjects was significantly lower (4.8 ± 0.6) than that for women on the pill (9.0 ± 1.6) or for pregnant women (7.5 ± 1.7). In contrast to their mothers, the neonates had an F/E ratio of 0.85 ± 0.34 with a mother /cord ratio for F of 4.9 ± 2.5 and for E of 0.50 ± 0.15.In eight fetuses of 3-6 months of gestational age, plasma concentrations of F (2.1 ± 1.2 jug/100 ml) and E (4.7 ± 3.3 jug/100 ml) were lower than those of six neonates (6.3 db 2.9 for F and 7.2 ± 1.2 /ig/100 ml for E).For control subjects, the Cr F^E was significantly higher and the Cr E^F significantly lower than these ratios for pregnant women and for women on contraceptive medication. From the values of BP (F) for each subject and the corresponding transfer constant [P]BB E it was estimated that all the BP (E) for the subjects studied arose from BP (F), which suggested that, within the limits of error of the methods used, there was no E secretion. SpeculationFrom previous studies in sheep, it was demonstrated that cortisol crossed the placenta from the mother to the fetus but that the fetus near term was also able to secrete cor-509 510 BEITINS ET AL.tisol. In this study of pregnant women we were able to calculate the maternal contribution to the fetal cortisol and cortisone concentration and to show that the fetus secretes three-fourths of its cortisol but that its cortisone was mainly maternal in origin. We were also able to show that cortisol and cortisone concentrations, similar to those at term, existed in utero as early as the 3rd month. We therefore speculate that the human fetal adrenal is capable of corticosteroid secretion early in pregnancy.

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“…preferida durante a gestação. 2 Alguns estudos apontam um aumento do risco de fendas orofaciais quando os corticosteróides são administrados no mês que antecede a conceção e durante o primeiro trimestre de gestação. 3,4 A sua utilização durante a gestação pode resultar ainda em parto prematuro, rotura prematura de membranas, restrição de crescimento intrauterino, diabetes gestacional, hipertensão arterial, pré-eclâmpsia e eclâmpsia.…”

Section: Corticosteróides Sistémicos (Categoria De Risco C Pela Food unclassified

Gravidez, Aleitamento e Fármacos em Dermatologia - Tratamento Sistémico

Cesar

Azevedo

Mota

2016

SPDV

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RESUMO -O crescente número de fármacos empregues na prática dermatológica e venereológica exige do dermatologista um conhecimento atualizado relativo à sua segurança. No caso particular de mulheres grávidas ou que amamentem, a decisão sobre se se deve ou não tratar com um determinado fármaco deve basear-se numa avaliação ponderada dos benefícios para a saúde materna e dos riscos potenciais para o bem-estar fetal ou do lactente. Quando estas doentes necessitam terapêuticas tópicas ou sistémicas, a maioria pode ser adequadamente tratada com opções consideradas seguras e eficazes. Na primeira parte deste artigo são abordados os dados mais recentes relativos à segurança de alguns dos medicamentos sisté-micos mais comummente usados em contexto dermatológico, na mulher em idade fértil. PALAVRAS-CHAVE -Agentes Dermatológicos/uso terapêutico; Aleitamento/efeito dos medicamentos; Complicações na Gravidez/quimioterapia; Doenças da Pele/quimioterapia; Doenças de Pele/tratamento; Gravidez. Pregnancy, Lactation and Drugs in DermatologySystemic Therapy ABSTRACT -The increasing number of drugs used in dermatological a venereological practice demands from the dermatologist INTRODUÇÃOAo tratar doentes grávidas ou durante o período de aleitamento é fundamental um conhecimento dos potenciais efeitos adversos dos medicamentos sobre o desenvolvimento do feto ou do lactente. O risco de teratogenicidade e a capacidade de cada fármaco ser excretado no leite materno permite, na maioria das ocasiões, optar por alternativas seguras no tratamento de doenças do foro dermatológico em mulheres durante o período gestacional e durante a amamentação.Este artigo de revisão tem por objetivo abordar os dados disponíveis referentes à segurança (ou falta dela) de alguns dos fármacos mais comummente prescritos em contexto dermatológico e venereológico nas mulheres em idade fér-til. A primeira parte deste artigo aborda os fármacos administrados por via sistémica e a segunda parte irá abordar os fármacos de aplicação local. Corticosteróides sistémicos (categoria de risco C pela Food Drug Administration -FDA)A dexametasona e a betametasona não sofrem metabolização placentária significativa, passando inalterados através da placenta.1 Já a prednisolona sofre conversão em metabolitos inativos pela placenta humana, o que limita a sua passagem para o embrião/feto, pelo que é a opção

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The transplacental passage of prednisone and prednisolone in pregnancy near term

Cited by 245 publications

References 28 publications

Sexual and Reproductive Function in Chronic Kidney Disease and Effect of Kidney Transplantation

Sexual and Reproductive Function in Chronic Kidney Disease and Effect of Kidney Transplantation

The Metabolic Clearance Rate, Blood Production, Interconversion and Transplacental Passage of Cortisol and Cortisone in Pregnancy Near Term

Gravidez, Aleitamento e Fármacos em Dermatologia - Tratamento Sistémico

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