The transcriptional STAT3 is a potential target, whereas transcriptional STAT5A/5B/6 are new biomarkers for prognosis in human breast carcinoma

Abstract

Signal Transducer and Activators of Transcription (STAT) is a set of transcription factors, involved in diverse cellular functions. Evidences from cell lines, mouse models and human tissues implicate these transcription factors in the oncogenesis of breast cancer. However, the diverse expression patterns and prognostic values of 7 STATs remain to be elucidated. In the current study, we mined the transcriptional and survival data of STATs in patients with breast carcinoma (BC) through ONCOMINE, bc-GenExMiner, Kaplan-Meier Plotter and cBioPortal. It was found that STAT1/2 were up-regulated, whereas STAT3/4/5A/5B were down-regulated in BC patients compared with the normal tissues. The expressions of STAT5A/5B/6 were correlated with decreased levels of histological differentiation. In survival analyses through the Kaplan-Meier plotter database, high transcription levels of STAT2/4/5A/5B/6 were associated with better relapse-free survival (RFS) in all BC patients. Conversely, high STAT3 predicted shorter RFS in BC patients, suggesting that STAT3 is potential targets for precision therapy to BC patients. These data also provided STAT5A/5B/6 as new biomarker for BC prognosis.

Regulatory network of circRNA–miRNA–mRNA contributes to the histological classification and disease progression in gastric cancer

“…A total of 876 GC patients were recruited from the Kaplan–Meier Plotter online database. Subjects were split into two groups by median expression (high vs. low expression) and assessed by a Kaplan–Meier survival plot, with the hazard ratio (HR) with 95% confidence intervals (CI) and logrank P value as previous report [ 32 , 33 ].…”

Opioids trigger breast cancer metastasis through E-Cadherin downregulation and STAT3 activation promoting epithelial-mesenchymal transition

“…However, it was surprising that STAT5 remained unaffected by the opioid, especially as STAT5A and STAT5B are downstream targets of DOR in neuronal cells suggesting that GPCRmediated STAT3 docking is unique (35,36). We and others have shown that STAT3 is more highly expressed in BCa cells than STAT5 (37). Thus, it is likely that oncogenic STAT3 action by DOR ligation dominates BCa cell progression in a vicious cycle through EMT induction.…”

Loss of STAT6 leads to anchorage-independent growth and trastuzumab resistance in HER2+ breast cancer cells

“…However, our findings regarding COL1A2 are in agreement with previous studies implicating STAT6 expression in driving apoptosis [24] and thus loss of STAT6 would prevent apoptosis. Others have found that STAT6 loss is a negative prognostic marker in HER2-positive breast cancers [29].…”