The Transcription Factor T-box 3 Regulates Colony-stimulating Factor 1-dependent Jun Dimerization Protein 2 Expression and Plays an Important Role in Osteoclastogenesis

Chen, Yao; Yao, Gang‐Qing; Sun, Ben‐hua; Zhang, Changqing; Tommasini, Steven M.; Insogna, Karl L.

doi:10.1074/jbc.m113.499210

Cited by 12 publications

(7 citation statements)

References 48 publications

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“…Although jdp2 can also be expressed in neutrophilic granulocytes or dendritic cells [ 32 ], we did not observe inflammation in the local tissues (Figs 3 and 5 ). During osteoclast differentiation, jdp2 combines with fra2 to form AP-1, which initiates osteoclasts differentiation [ 22 , 33 ]. Meanwhile, nfatc1 regulates the transcription of ctsk and trap [ 21 ], which indicate osteoclast activity [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Osteoclastogenesis in Local Alveolar Bone in Early Decortication-Facilitated Orthodontic Tooth Movement

et al. 2016

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ObjectiveIn the current study, we aimed to investigate the effects of alveolar decortication on local bone remodeling, and to explore the possible mechanism by which decortication facilitates tooth movement.Materials and MethodsForty rabbits were included in the experiment. The left mandible was subjected to decortication-facilitated orthodontics, and the right mandible underwent traditional orthodontics as a control. The animals were sacrificed on the days 1, 3, 5, 7 and 14, after undergoing orthodontic procedures. Tooth movement was measured by Micro-CT, and the local periodontal tissues were investigated using H&E, Masson's trichrome and tartrate-resistant acid phosphatase (TRAP) staining. The mRNA levels of genes related to bone remodeling in the alveolar bone were analyzed using real-time PCR.ResultOn days 3, 5, 7 and 14, tooth movement was statistically accelerated by decortication (P < 0.05) and was accompanied by increased hyperemia. Despite the lack of new bone formation in both groups, more osteoclasts were noted in the decorticated group, with two peak counts (P < 0.05). The first peak count was consistent with the maximum values of ctsk and TRAP expression, and the second peak counts accompanied the maximum nfatc1 and jdp2 expression. The increased fra2 expression and the ratio of rankl/opg also accompanied the second peak counts.ConclusionsFollowing alveolar decortication, osteoclastogenesis was initially induced to a greater degree than the new bone formation which was thought to have caused a regional acceleratory phenomenon (RAP). The amount of steoclastogenesis in the decorticated alveolar bone was found to have two peaks, perhaps due to attenuated local resistance. The first peak count in osteoclasts may have been due to previously existing osteoclast precursors, whereas the second may represent the differentiation of peripheral blood mononuclear cells which came from circulation as the result of hyperemia.

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Section: Discussionmentioning

confidence: 99%

Osteoclastogenesis in Local Alveolar Bone in Early Decortication-Facilitated Orthodontic Tooth Movement

et al. 2016

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“…For example, col11a1b is on scaffold 21, and the homolog is responsible for both Stickler (OMIM: 108300) and Marshall (OMIM: 154780) syndromes in humans, which are characterized by an array of craniofacial abnormalities. In addition, the adjacent genes tbx3a and tbx5a are on scaffold 0, which play critical roles in skeletal development and homeostasis ( Govoni et al 2009 ; Yao et al 2014 ), and are implicated in human skeletal malformations ( e.g. , ulnar-mammary syndrome, OMIM: 181450; Holt-Oram syndrome, OMIM: 142900).…”

Section: Discussionmentioning

confidence: 99%

Nested Levels of Adaptive Divergence: The Genetic Basis of Craniofacial Divergence and Ecological Sexual Dimorphism

Parsons

Wang

Anderson

et al. 2015

G3 Genes|Genomes|Genetics

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Exemplary systems for adaptive divergence are often characterized by their large degrees of phenotypic variation. This variation represents the outcome of generations of diversifying selection. However, adaptive radiations can also contain a hierarchy of differentiation nested within them where species display only subtle phenotypic differences that still have substantial effects on ecology, function, and ultimately fitness. Sexual dimorphisms are also common in species displaying adaptive divergence and can be the result of differential selection between sexes that produce ecological differences between sexes. Understanding the genetic basis of subtle variation (between certain species or sexes) is therefore important for understanding the process of adaptive divergence. Using cichlids from the dramatic adaptive radiation of Lake Malawi, we focus on understanding the genetic basis of two aspects of relatively subtle phenotypic variation. This included a morphometric comparison of the patterns of craniofacial divergence between two ecologically similar species in relation to the larger adaptive radiation of Malawi, and male–female morphological divergence between their F2 hybrids. We then genetically map craniofacial traits within the context of sex and locate several regions of the genome that contribute to variation in craniofacial shape that is relevant to sexual dimorphism within species and subtle divergence between closely related species, and possibly to craniofacial divergence in the Malawi radiation as a whole. To enhance our search for candidate genes we take advantage of population genomic data and a genetic map that is anchored to the cichlid genome to determine which genes within our QTL regions are associated with SNPs that are alternatively fixed between species. This study provides a holistic understanding of the genetic underpinnings of adaptive divergence in craniofacial shape.

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“…While the mechanism through which SH3BP1 acts is unclear, PSTPIP2-mediated suppression of TRAP expression requires both its association with PEST-family phosphatases and its CSF-1R-induced tyrosine phosphorylation (Chitu et al, 2012). Another event critical for induction of TRAP expression is the Tbx3-dependent induction of Jun dimerization protein 2 (JDP2) expression by the CSF-1/Erk1/2 pathway (Yao et al, 2014). JDP2 mediates RANKL-induced upregulation of TRAP and Cathepsin K (Kawaida et al, 2003).…”

Section: Regulation Of Osteoclasts and Bone Development By Csf-1mentioning

confidence: 99%

Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor

Chiţu

Stanley

2017

Current Topics in Developmental Biology

116

118

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Macrophages are found in all tissues and regulate tissue morphogenesis during development through trophic and scavenger functions. The colony stimulating factor-1 (CSF-1) receptor (CSF-1R) is the major regulator of tissue macrophage development and maintenance. In combination with receptor activator of nuclear factor κB (RANK), the CSF-1R also regulates the differentiation of the bone-resorbing osteoclast and controls bone remodeling during embryonic and early postnatal development. CSF-1R-regulated macrophages play trophic and remodeling roles in development. Outside the mononuclear phagocytic system, the CSF-1R directly regulates neuronal survival and differentiation, the development of intestinal Paneth cells and of preimplantation embryos, as well as trophoblast innate immune function. Consistent with the pleiotropic roles of the receptor during development, CSF-1R deficiency in most mouse strains causes embryonic or perinatal death and the surviving mice exhibit multiple developmental and functional deficits. The CSF-1R is activated by two dimeric glycoprotein ligands, CSF-1, and interleukin-34 (IL-34). Homozygous Csf1-null mutations phenocopy most of the deficits of Csf1r-null mice. In contrast, Il34-null mice have no gross phenotype, except for decreased numbers of Langerhans cells and microglia, indicating that CSF-1 plays the major developmental role. Homozygous inactivating mutations of the Csf1r or its ligands have not been reported in man. However, heterozygous inactivating mutations in the Csf1r lead to a dominantly inherited adult-onset progressive dementia, highlighting the importance of CSF-1R signaling in the brain.

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The Transcription Factor T-box 3 Regulates Colony-stimulating Factor 1-dependent Jun Dimerization Protein 2 Expression and Plays an Important Role in Osteoclastogenesis

Cited by 12 publications

References 48 publications

Osteoclastogenesis in Local Alveolar Bone in Early Decortication-Facilitated Orthodontic Tooth Movement

Osteoclastogenesis in Local Alveolar Bone in Early Decortication-Facilitated Orthodontic Tooth Movement

Nested Levels of Adaptive Divergence: The Genetic Basis of Craniofacial Divergence and Ecological Sexual Dimorphism

Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor

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