2016
DOI: 10.1371/journal.pone.0153937
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Osteoclastogenesis in Local Alveolar Bone in Early Decortication-Facilitated Orthodontic Tooth Movement

Abstract: ObjectiveIn the current study, we aimed to investigate the effects of alveolar decortication on local bone remodeling, and to explore the possible mechanism by which decortication facilitates tooth movement.Materials and MethodsForty rabbits were included in the experiment. The left mandible was subjected to decortication-facilitated orthodontics, and the right mandible underwent traditional orthodontics as a control. The animals were sacrificed on the days 1, 3, 5, 7 and 14, after undergoing orthodontic proce… Show more

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Cited by 21 publications
(17 citation statements)
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“…In 24‐well plates, Raw 264.7 were seeded at 1000 cells well −1 , and recombinant murine RANKL (R&D; 12 ng µL −1 ) was added into the conditioned medium for osteoclastogenic induction. Raw 264.7 were maintained for 10 days and stained using a tartrate‐resistant acid phosphatase (TRAP) Kit (Sigma, St. Louis, MO, USA; Wang & Li , Wang et al 2015a, Wang et al 2015b, Chen et al ). Cells stained with TRAP (Trap+) and containing at least three nuclei (Trap + MNCs) were the osteoclast‐like cells.…”
Section: Methodsmentioning
confidence: 99%
“…In 24‐well plates, Raw 264.7 were seeded at 1000 cells well −1 , and recombinant murine RANKL (R&D; 12 ng µL −1 ) was added into the conditioned medium for osteoclastogenic induction. Raw 264.7 were maintained for 10 days and stained using a tartrate‐resistant acid phosphatase (TRAP) Kit (Sigma, St. Louis, MO, USA; Wang & Li , Wang et al 2015a, Wang et al 2015b, Chen et al ). Cells stained with TRAP (Trap+) and containing at least three nuclei (Trap + MNCs) were the osteoclast‐like cells.…”
Section: Methodsmentioning
confidence: 99%
“…Four-week-old male BALB/c nude mice were purchased from Vital River Experimental Animal Technique Company (Beijing, China) and maintained in a specific pathogen-free condition. All the animals were acclimatized for 1 week before experiments, and then maintained under controlled temperature (22±2°C), with light dark periods of 12 hours and with free access to water and commercial diet [ 36 ].…”
Section: Methodsmentioning
confidence: 99%
“…7 In addition, the regional acceleratory phenomenon (RAP) is activated by the Review Facial asymmetry correction: From conventional orthognathic treatment to surgery-first approach Tahereh Hosseinzadeh Nik 1 • Elahe Gholamrezaei 1 • Mohammad Ali Keshvad 1 * orthognathic surgery as part of the wound healing process and can play an important role in shortening of the treatment course. 8,9 Evidence shows that the serum level of alkaline phosphatase, which is a key enzyme in bone formation, increases as part of the RAP process four weeks after surgery, and its level remains high for up to four months postoperatively. 10 The absence of a tight occlusion at the time of orthognathic surgery is a double-blade sword.…”
Section: Introductionmentioning
confidence: 99%