The toxic cosmopolitan cyanobacteria Moorena producens: insights into distribution, ecophysiology and toxicity

Curren, Emily; Leaw, Chui Pin; Lim, Po Teen; Leong, Sandric Chee Yew

doi:10.1007/s11356-022-23096-4

Cited by 5 publications

(3 citation statements)

References 219 publications

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“…This species is a benthic filamentous cyanobacterium that has a global distribution and can form harmful blooms in marine ecosystems. It produces a variety of bioactive secondary metabolites, such as malyngamides, microcolins and dolastatins, that have toxic effects on various organisms and human health but also potential pharmaceutical applications [ 19 ]. Despite having the highest number of detected clusters, it does not have the most predicted molecules.…”

Section: Resultsmentioning

confidence: 99%

MariClus: Your One-Stop Platform for Information on Marine Natural Products, Their Gene Clusters and Producing Organisms

et al. 2023

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Background: The marine environment hosts the vast majority of living species and marine microbes that produce natural products with great potential in providing lead compounds for drug development. With over 70% of Earth’s surface covered in water and the high interaction rate associated with liquid environments, this has resulted in many marine natural product discoveries. Our improved understanding of the biosynthesis of these molecules, encoded by gene clusters, along with increased genomic information will aid us in uncovering even more novel compounds. Results: We introduce MariClus (https://www.mariclus.com), an online user-friendly platform for mining and visualizing marine gene clusters. The first version contains information on clusters and the predicted molecules for over 500 marine-related prokaryotes. The user-friendly interface allows scientists to easily search by species, cluster type or molecule and visualize the information in table format or graphical representation. Conclusions: This new online portal simplifies the exploration and comparison of gene clusters in marine species for scientists and assists in characterizing the bioactive molecules they produce. MariClus integrates data from public sources, like GenBank, MIBiG and PubChem, with genome mining results from antiSMASH. This allows users to access and analyze various aspects of marine natural product biosynthesis and diversity.

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Section: Resultsmentioning

confidence: 99%

MariClus: Your One-Stop Platform for Information on Marine Natural Products, Their Gene Clusters and Producing Organisms

et al. 2023

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“…The oxygen sensitive looekeyolide A reduces hydrogen peroxide levels, suggesting a role in combating reactive oxygen species on the coral surface [ 10 ]. Malyngamides from filamentous cyanobacteria have demonstrated both cytotoxic and anticancer properties [ 37 ] and antibacterial properties against Gram positive pathogens [ 38 ]. Malyngamide C and lyngbic acid have also demonstrated quorum-sensing inhibition in marine bacteria [ 9 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Cryptic Diversity of Black Band Disease Cyanobacteria in Siderastrea siderea Corals Revealed by Chemical Ecology and Comparative Genome-Resolved Metagenomics

et al. 2023

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Black band disease is a globally distributed and easily recognizable coral disease. Despite years of study, the etiology of this coral disease, which impacts dozens of stony coral species, is not completely understood. Although black band disease mats are predominantly composed of the cyanobacterial species Roseofilum reptotaenium, other filamentous cyanobacterial strains and bacterial heterotrophs are readily detected. Through chemical ecology and metagenomic sequencing, we uncovered cryptic strains of Roseofilum species from Siderastrea siderea corals that differ from those on other corals in the Caribbean and Pacific. Isolation of metabolites from Siderastrea-derived Roseofilum revealed the prevalence of unique forms of looekeyolides, distinct from previously characterized Roseofilum reptotaenium strains. In addition, comparative genomics of Roseofilum strains showed that only Siderastrea-based Roseofilum strains have the genetic capacity to produce lasso peptides, a family of compounds with diverse biological activity. All nine Roseofilum strains examined here shared the genetic capacity to produce looekeyolides and malyngamides, suggesting these compounds support the ecology of this genus. Similar biosynthetic gene clusters are not found in other cyanobacterial genera associated with black band disease, which may suggest that looekeyolides and malyngamides contribute to disease etiology through yet unknown mechanisms.

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“…Reviews focused on marine cyanobacteria included a comprehensive review of the distribution, NP chemistry, and ecology of Moorena producens , 108 and the anti-infective potential of the NPs reported from this genus. 109 Cytotoxic, antiproliferative and antineoplastic activities 110 and anti-inflammatory, antioxidant, antimicrobial, antiviral and anticancer activities of cyanobacterial NPs were also reviewed.…”

Section: Marine Microorganisms and Phytoplanktonmentioning

confidence: 99%

Marine natural products

Carroll,

Copp,

Grkovic

et al. 2024

Nat. Prod. Rep.

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The toxic cosmopolitan cyanobacteria Moorena producens: insights into distribution, ecophysiology and toxicity

Cited by 5 publications

References 219 publications

MariClus: Your One-Stop Platform for Information on Marine Natural Products, Their Gene Clusters and Producing Organisms

MariClus: Your One-Stop Platform for Information on Marine Natural Products, Their Gene Clusters and Producing Organisms

Cryptic Diversity of Black Band Disease Cyanobacteria in Siderastrea siderea Corals Revealed by Chemical Ecology and Comparative Genome-Resolved Metagenomics

Marine natural products

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