Marine natural products

Carroll, Anthony R.; Copp, Brent R.; Grkovic, Tanja; Keyzers, Robert A.; Prinsep, Michèle R.

doi:10.1039/d3np00061c

Nat. Prod. Rep.

2024

DOI: 10.1039/d3np00061c

|View full text |Cite

Marine natural products

Anthony R. Carroll,

Brent R. Copp,

Tanja Grkovic

et al.

Abstract: A comprehensive review of 1411 new MNPs and their structural diversity analysis and including the cyanobacterial metabolite lezoside.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 7 publications

References 650 publications

(813 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

New Hydroxyphenylacetic Acids and α‐Pyrone Derivative from the Deep‐Sea Cold Seep Sediment‐Derived Fungus Penicillium corylophilum CS‐682

Zhu,

Li,

Yang

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Two pairs of new enantiomeric hydroxyphenylacetic acid derivatives, (±)‐corylophenols A and B ((±)‐1 and (±)‐2), a new α‐pyrone analogue, corylopyrone A (3), and six andrastin‐type meroterpenoids (4–9) were isolated and identified from the deep‐sea cold‐seep sediment‐derived fungus Penicillium corylophilum CS‐682. Their structures and stereo configurations were determined by detailed spectroscopic analysis of NMR and MS data, chiral HPLC analysis, J‐based configuration analysis, and quantum chemical calculations of ECD, specific rotation, and NMR (with DP4+ probability analysis). Compound 3 showed inhibitory activity against some strains of pathogenic bacteria.

show abstract

New Hydroxyphenylacetic Acids and α‐Pyrone Derivative from the Deep‐Sea Cold Seep Sediment‐Derived Fungus Penicillium corylophilum CS‐682

Zhu,

Li,

Yang

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

Retrobisabolane A, a Novel Bisabolane‐Derived Sesquiterpenoid Isolated from Deep‐Sea‐Derived Fungus Retroconis fusiformis MCCC 3A00792

Liu,

Lv,

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

One novel bisabolane‐derived sesquiterpenoid retrobisabolane A (1), featuring a methyl group location at the C‐4 position instead of C‐3 in the bisabolanes, and a known ester‐substituted eremophilane‐type sesquiterpenoid cryptosphaerolide (2), along with three known indole alkaloids (3‒5) were discovered from the fermented cultures of a deep‐sea‐derived fungus Retroconis fusiformis MCCC 3A00792. The planar structure of new compound 1 was determined by extensive analysis of the NMR and HRESIMS spectra. The relative and absolute configurations of 1 were resolved by the coupling constant (J), calculation of ECD and NMR spectra, and the DP4+ probability analysis of the 1H and 13C NMR data. Interestingly, retrobisabolane A was the new subclass of bisabolanes bearing a methyl group linkage at C‐4 instead of C‐3 position. Three human cancer cell lines (Hela, AGS, and BIU‐87) were subjected to evaluate the cytotoxic activities of compounds 1‒5. As a result, compound 2 exhibited significant inhibitory activities against three cell lines with IC50 values ranging from 9.95 to 18.77 μM.

show abstract

Meroterpenoids from Marine Sponge Hyrtios sp. and Their Anticancer Activity against Human Colorectal Cancer Cells

Wang,

Yan,

et al. 2024

Marine Drugs

View full text Add to dashboard Cite

Two new meroterpenoids, hyrtamide A (1) and hyrfarnediol A (2), along with two known ones, 3-farnesyl-4-hydroxybenzoic acid methyl ester (3) and dictyoceratin C (4), were isolated from a South China Sea sponge Hyrtios sp. Their structures were elucidated by NMR and MS data. Compounds 2–4 exhibited weak cytotoxicity against human colorectal cancer cells (HCT-116), showing IC50 values of 41.6, 45.0, and 37.3 μM, respectively. Furthermore, compounds 3 and 4 significantly suppressed the invasion of HCT-116 cells while also downregulating the expression of vascular endothelial growth factor receptor 1 (VEGFR-1) and vimentin proteins, which are key markers associated with angiogenesis and epithelial–mesenchymal transition (EMT). Our findings suggest that compounds 3 and 4 may exert their anti-invasive effects on tumor cells by inhibiting the expression of VEGFR-1 and impeding the process of EMT.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Marine natural products

Abstract: A comprehensive review of 1411 new MNPs and their structural diversity analysis and including the cyanobacterial metabolite lezoside.

Cited by 7 publications

References 650 publications

New Hydroxyphenylacetic Acids and α‐Pyrone Derivative from the Deep‐Sea Cold Seep Sediment‐Derived Fungus Penicillium corylophilum CS‐682

New Hydroxyphenylacetic Acids and α‐Pyrone Derivative from the Deep‐Sea Cold Seep Sediment‐Derived Fungus Penicillium corylophilum CS‐682

Retrobisabolane A, a Novel Bisabolane‐Derived Sesquiterpenoid Isolated from Deep‐Sea‐Derived Fungus Retroconis fusiformis MCCC 3A00792

Meroterpenoids from Marine Sponge Hyrtios sp. and Their Anticancer Activity against Human Colorectal Cancer Cells

Contact Info

Product

Resources

About