The Touch Corpuscles of the Plantar Surface of the Big Toe

Schimrigk, К.; Rüttinger, H

doi:10.1159/000115128

Cited by 25 publications

(4 citation statements)

References 4 publications

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“…Notably, this distribution is similar to the palatal localization of NCSCs in rats (Widera et al, 2009 ) and mice (Widera et al, 2012 ) where numerous Nestin-positive NCSCs within Meissner corpuscles can be observed in the lamina propria of hard palate. Interestingly, in humans the number of Meissner corpuscles and consequently NCSCs gradually decreases with age (Schimrigk and Ruttinger, 1980 ). Thus, future studies investigating if this tendency can be observed in sheep could be of high interest for the regenerative medicine.…”

Section: Discussionmentioning

confidence: 99%

Isolation and Characterization of Neural Crest-Derived Stem Cells From Adult Ovine Palatal Tissue

Zeuner

Didenko

Humphries

et al. 2018

Front. Cell Dev. Biol.

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Adult mammalian craniofacial tissues contain limited numbers of post-migratory neural crest-derived stem cells. Similar to their embryonic counterparts, these adult multipotent stem cells can undergo multi-lineage differentiation and are capable of contributing to regeneration of mesodermal and ectodermal cells and tissues in vivo. In the present study, we describe for the first time the presence of Nestin-positive neural crest-derived stem cells (NCSCs) within the ovine hard palate. We show that these cells can be isolated from the palatal tissue and are able to form neurospheres. Ovine NCSCs express the typical neural crest markers Slug and Twist, exhibit high proliferative and migratory activity and are able to differentiate into α smooth muscle cells and β-III-tubulin expressing ectodermal cells. Finally, we demonstrate that oNCSCs are capable of differentiating into osteogenic, adipogenic and chondrogenic cells. Taken together, our results suggest that oNCSCs could be used as model cells to assess the efficacy and safety of autologous NCSC transplantation in a large animal model.

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Section: Discussionmentioning

confidence: 99%

Isolation and Characterization of Neural Crest-Derived Stem Cells From Adult Ovine Palatal Tissue

Zeuner

Didenko

Humphries

et al. 2018

Front. Cell Dev. Biol.

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“…In particular, numerous Nestin-positive MCs can be observed in the lamina propria of hard palate, whereas nearly no MCs are present in the soft palate. In humans, the number of MCs gradually decreases with age [4]. …”

Section: Introductionmentioning

confidence: 99%

Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells

Widera

Hauser

Kaltschmidt

et al. 2012

Anatomy Research International

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Meissner corpuscles and Merkel cell neurite complexes are highly specialized mechanoreceptors present in the hairy and glabrous skin, as well as in different types of mucosa. Several reports suggest that after injury, such as after nerve crush, freeze injury, or dissection of the nerve, they are able to regenerate, particularly including reinnervation and repopulation of the mechanoreceptors by Schwann cells. However, little is known about mammalian cells responsible for these regenerative processes. Here we review cellular origin of this plasticity in the light of newly described adult neural crest-derived stem cell populations. We also discuss further potential multipotent stem cell populations with the ability to regenerate disrupted innervation and to functionally recover the mechanoreceptors. These capabilities are discussed as in context to cellularly reprogrammed Schwann cells and tissue resident adult mesenchymal stem cells.

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“…Individual differences in touch might be influenced by age because function in main sensory modalities has been found to decline with age (Victor and Ropper, 2001; Wickremaratchi and Llewelyn, 2006). This may be related to the gradual decline in the number of cells and fibers in the central and peripheral nervous system (Bolton et al, 1966; McLeod, 1980; Schimrigk and Ruttinger, 1980; Katzman and Terry, 1983; Gescheider et al, 1994a; Stevens and Patterson, 1995). Moreover, older people are significantly less sensitive to mechanical stimuli, and their tactile, vibration, pain, and temperature thresholds are significantly higher (Thornbury and Mistretta, 1981; Kenshalo, 1986; Tucker et al, 1989; Gescheider et al, 1994b, 1996; Goble et al, 1996; Verrillo et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Visualizing Individual Perceptual Differences Using Intuitive Word-Based Input

Sakamoto

Watanabe

2019

Front. Psychol.

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Numerous studies have investigated the fundamental dimensions of human tactile perceptual space using a wide range of materials. Participants generally touch materials and quantitatively evaluate variations in tactile sensations for pairs of adjectives pertaining to the material properties, such as smooth—rough and soft—hard. Thus, observers evaluate their perceptual experiences one by one in terms of adjective pairs. We previously proposed an alternative method of qualitative evaluation of tactile sensations. Our system can automatically estimate ratings of fundamental tactile properties from single sound-symbolic words. We were able to construct a word-based perceptual space by collecting words that express tactile sensations and applying them to the system. However, to explore individual differences in perceptual spaces, different databases for converting words into ratings of adjective pairs are required for each individual. To address this, in the present study we created an application that can automatically generate an individualized perceptual space by moving only a few words in the initial word-based perceptual space. In addition, we evaluated the efficacy of the application by comparing the tactile perceptual space before and after use.

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The Touch Corpuscles of the Plantar Surface of the Big Toe

Cited by 25 publications

References 4 publications

Isolation and Characterization of Neural Crest-Derived Stem Cells From Adult Ovine Palatal Tissue

Isolation and Characterization of Neural Crest-Derived Stem Cells From Adult Ovine Palatal Tissue

Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells

Visualizing Individual Perceptual Differences Using Intuitive Word-Based Input

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