The total sale of prescription drugs with an abuse potential predicts the number of excessive users: a national prescription database study

Rossow, Ingeborg; Bramness, Jørgen G.

doi:10.1186/s12889-015-1615-7

Cited by 19 publications

(18 citation statements)

References 26 publications

(24 reference statements)

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“…The empirical support of the TCM with regard to gambling resembles that from the alcohol epidemiology literature (Norströ m et al, 2002;Rossow & Norström, 2013;Skog, 1985) and fits into a more general picture of the distribution of health hazards and incidence of health problems in populations (Bramness & Rossow, 2010;Rose, 2001;Rose & Day, 1990;Rossow & Bramness, 2015). In line with Rose (2001;Rose & Day, 1990) and Skog (1985), such regularities in population distributions suggest that factors at the population or aggregate level also impact on the level of excessive consumption and related harm.…”

Section: Discussionsupporting

confidence: 55%

The total consumption model applied to gambling: Empirical validity and implications for gambling policy

Rossow

2018

Nordic Studies on Alcohol and Drugs

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Aim: The total consumption model (TCM) originates from studies of the distribution of alcohol consumption and posits that there is a strong association between the total consumption and the prevalence of excessive/harmful consumption in a population. The policy implication of the TCM is that policy measures which effectively lead to a reduction of the total consumption, will most likely also reduce the extent of harmful consumption and related harms. Problem gambling constitutes a public health issue and more insight into problem gambling at the societal level and a better understanding of how public policies may impact on the harm level, are strongly needed. The aim of this study was to review the literature pertaining to empirical validity of the TCM with regard to gambling behaviour and problem gambling and, on the basis of the literature review, to discuss the policy implications of the TCM. Methods: The study is based on a literature mapping through systematic searches in literature databases, and forward and backward reference searches. Results: The literature searches identified a total of 12 empirical studies that examined the total consumption model or provided relevant data. All but one of these studies found empirical support for the TCM; that is, a positive association between population gambling mean and prevalence of excessive or problem gambling. Such associations were found both with cross-sectional data and with longitudinal data. Conclusion: There is a small but fairly consistent literature lending empirical support to the total consumption model. An important policy implication is that

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Section: Discussionsupporting

confidence: 55%

The total consumption model applied to gambling: Empirical validity and implications for gambling policy

Rossow

2018

Nordic Studies on Alcohol and Drugs

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“…Because the incident use of pregabalin is four times higher than that observed with gabapentin, the likelihood that vulnerable subjects will be exposed to misuse or to other adverse outcomes is higher for pregabalin . This situation has been observed previously in similar contexts with other drugs …”

Section: Discussionmentioning

confidence: 52%

Patterns of gabapentin and pregabalin use and misuse: Results of a population‐based cohort study in France

Driot

Jouanjus

Oustric

et al. 2019

Brit J Clinical Pharma

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Aims: The aim of this study was to assess the use and factors associated with the misuse of gabapentin and pregabalin in the general French population, through a cohort study in the EGB (General Sample of Beneficiaries), a national representative sample of the French general population.Methods: New users of gabapentin and pregabalin were identified from June 2006 to December 2014, and new users of duloxetine served as control group. Misuse was defined as a use of higher daily doses than recommended. Cox proportional hazard regression models were performed to identify associated factors of misuse.Results: Misuse was more frequent in the 8692 new users of pregabalin (12.8%) than in the 1963 gabapentin (6.6%) or the 3214 duloxetine new users (9.7%) (P < 0.001). Factors associated with misuse were pregabalin (hazard ratio [HR] 1.48; 95% confidence interval [CI] [1.29-1.69]), age (HR [18-45] versus > 70 years 1.98 [1.70-2.31] and HR [58-70] versus > 70 years 1.25 [1.06-1.47]), multiple prescribers (HR 2 or 3 versus 1 prescriber 1.29 [1.15-1.45]; HR 4 or more versus 1 prescriber 1.54 [1.30-1.83]), cancer (1.28 [1.11-1.47]), multiple sclerosis (1.53 [1.07-2.18]), neuropathy (1.85 [1.19-2.89]), depression (1.26 [1.07-1.49]) and methadone (2.61 [1. 16-5.84]). After this first episode of drug misuse, 11.6% of gabapentin and 10.7% of pregabalin misusers developed a primary addiction.Conclusion: In a cohort of new users, misuse is more likely to occur in new users of pregabalin, with different associated factors of misuse compared to gabapentin and duloxetine. Health professionals and prescribers must be aware of this misuse potential, which could lead to abuse and dependence.

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“…In the USA, the increased pregabalin use has also been related to 'off-label' use as an alternative to opioids for various pain management [108]. Moreover, Rossow and Bramness [109] have shown that the consumption of prescription drugs with an abuse potential is skewedly distributed and that few excessive users account for a disproportionately high proportion of the drug sales.…”

Section: Recommendations To Authoritiesmentioning

confidence: 99%

Current Evidence on Abuse and Misuse of Gabapentinoids

2020

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This review summarizes current evidence on the abuse and misuse of the gabapentinoids pregabalin and gabapentin. Pharmacovigilance studies, register-based studies, surveys, clinical toxicology studies, and forensic toxicology studies were identified and scrutinized with the goal to define the problem, identify risk factors, and discuss possible methods to reduce the potential for abuse and misuse. Studies found that gabapentinoids are abused and misused and that individuals with a history of psychiatric disorders or substance use disorder seem to be at high risk. Moreover, some evidence supports the notion that patients with opioid use disorders may be at an increased risk of abusing gabapentinoids. Available evidence also suggests that abuse and misuse are more frequent in users of pregabalin compared with users of gabapentin. Health professionals and prescribers should be aware of the risk for misuse of pregabalin and gabapentin, which eventually could lead to abuse, substance dependence, and intoxications. Prescribing to patients belonging to risk populations such as those with psychiatric disorders or substance use disorder should be avoided if possible and, if prescribed, signs of misuse and abuse should be monitored.

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The total sale of prescription drugs with an abuse potential predicts the number of excessive users: a national prescription database study

Cited by 19 publications

References 26 publications

The total consumption model applied to gambling: Empirical validity and implications for gambling policy

The total consumption model applied to gambling: Empirical validity and implications for gambling policy

Patterns of gabapentin and pregabalin use and misuse: Results of a population‐based cohort study in France

Current Evidence on Abuse and Misuse of Gabapentinoids

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