The titanium-containing mesh as a perspective group of implants for abdominal wall repair

Kazantsev, A. B.; Паршиков, В. В.; Shemyatovsky, K A; Alekhin, A. I.; Titarov, D L; Kolpakov, A A; Osadchenko, S. V.

doi:10.17116/hirurgia2016486-95

Cited by 4 publications

(5 citation statements)

References 44 publications

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“…Проспективное исследование проводилось с июня 2017 по апрель 2019 г. Период включения в исследование: июнь−сентябрь 2017 г. Плановая кратность визитов - 3,6,9,12,15,18, 21 мес. Минимальная длительность наблюдения пациенток -18 мес.…”

Section: продолжительность исследованияunclassified

“…В странах Западной Европы нередко используют синтетические эндопротезы с титановым покрытием, обеспечивающим защиту биологических тканей от неблагоприятного воздействия полипропилена, в то время как в нашей стране разработаны и активно внедряются в клиническую практику сетчатые имплантаты различных размеров и форм из монофиламентных или полифиламентных титановых нитей (сплав ВТ1-00) с содержанием титана более 99%. Специальная технологическая обработка сетчатого полотна способствует снижению напряжения (атензионный эффект) в области межпетлевых контактов и, как следствие, повышению пластичности эндопротезов с формированием пористой сетчатой структуры с высокой степенью адгезии к раневой поверхности [9,10].…”

Section: описание медицинского вмешательстваunclassified

“…В процессе динамического амбулаторного наблюдения через 3,6,9,12,15,18, 21 мес после операции, при гинекологическом исследовании в покое и при пробе Вальсальвы, трансвагинальной и трансперинеальной эхографии, МРТ у всех пациенток I группы значимого смещения тазовых органов выявлено не было (табл. 3).…”

Section: A R T I C L E I N P R E S Sunclassified

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Surgical correction of prolapse of anterior wall of the vagina and cervix using titanium mesh implants

et al. 2020

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Background: Regardless of a variety of surgical techniques and hi-tech materials for pelvic prolapse treatment, there is no decrease in the disease recurrences. Aims: Evaluation of the efficacy of the developed method of surgical correction of IIIV degree colpoptosis anterior combined with IIIII degree C-prolapse with the use of titanium mesh implants in reproductive, pre- and postmenopausal female patients. Methods: Female patients (group I, n = 25) with colpoptosis anterior and cervical prolapse were examined and operated on according to the developed know-how technique with the use of titanium mesh implants. Evaluation of the efficacy of surgical correction of the disease was performed using questioning, pelvic exam with Valsalva manoeuvre, transvaginal and transperineal ultrasound, pelvis MRI. The findings were compared with the result of surgical treatment of 46 (group II) and 32 (group III) female patients operated on without the use of titanium implants. After surgical treatment according to the three-stage surgical program that provides for multifocal fixation of anatomical formations with the use of titanium implants, the case follow-up was performed in 321 months. Results: Questioning the patients in group I demonstrated their satisfaction with the surgical treatment results that positively affected the quality of life, mood, and contributed to an increase in sexual activity and community commitment. Check-up showed that the surgical correction of prolapse was completely preserved in the patients of group I during 1821 months. Pelvic exam at rest and with Valsalva manoeuvre, transvaginal and transperineal ultrasound, pelvis MRI did not reveal any significant extrusion of the pelvic organs or titanium implants. No mesh-associated complications were observed during the follow-up. Recurrence of genital prolapse was diagnosed in 12 (26%) patients of group II, mesh-associated complications were detected in 6 (18.8%) women of group III. Conclusions: The preserving three-stage surgical program, developed by us, contributed to optimize the results of surgical treatment, decrease the rate of the disease recurrence, and reduce the risk of the development of mesh-associated complications.

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Section: продолжительность исследованияunclassified

Section: описание медицинского вмешательстваunclassified

Section: A R T I C L E I N P R E S Sunclassified

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Surgical correction of prolapse of anterior wall of the vagina and cervix using titanium mesh implants

et al. 2020

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“…This is a new group of implants possessing some advantages, and their fabrication is based on principally different technological processes [23,24]. In some publications their capabilities have been appreciated as rather high, the authors report good experimental and clinical results [23][24][25][26][27][28][29].…”

Section: Biomedical Investigationsmentioning

confidence: 99%

Visceral Adhesions after Tension-Free Abdominal Wall Repair with Ultra-Lightweight Synthetic and Titanium-Containing Meshes

Паршиков¹,

Mironov²,

Kazantsev³

et al. 2017

Sovrem Tehnol Med

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Criteria of reliability and safety of abdominal wall prosthetic repair with the help of ultra-lightweight synthetic and titanium-containing materials are not clearly defined, and the results of their application are insufficiently studied.The aim of the investigation was to study in the experiment the intensity of the abdominal adhesive process after tension-free repair with ultra-lightweight synthetic and titanium-containing meshes.Materials and Methods. Ultra-lightweight synthetic and titanium-containing meshes were implanted to laboratory animals (n=128). Synthetic meshes (PP Light) were used in group 1, in group 2 titanium-containing meshes (TiMesh) were employed, and in group 3 meshes were from titanium filaments (Titan, Titanium silk).In the first series of the investigation, intraperitoneal onlay mesh (IPOM) technique was used, in the second series sublay retromuscular (SRM) repair was performed. 30 and 60 days later, the zone of implantation was examined with photofixation of the results, viscera-parietal adhesions were evaluated using a modified Vanderbilt assessment scale. Differences were considered statistically significant at p<0.05.Results. The intensity of the adhesive process was significantly higher in the IPOM series (4.0 points) in comparison with the SRM series (0.44 points), p=0.000. The intensity of this phenomenon in the PP Light, TiMesh, and Titan groups amounted on average to 2.73, 3.78, and 5.33 points, respectively. Differences of the results in the TiMesh group from the PP Light group were not statistically significant, p=0.07, however, they were significant with the Titan group, p=0.03. The intensity depended also on the postoperative period duration. In the PP Light group its value on day 30 and 60 was 3.16 and 2.20 points, respectively, p=0.22; in the TiMesh group it was 3.64 and 4.0 points, respectively, p=0.81; in the Titan group it was 6.60 and 4.42, p=0.004.Minimal formation of viscera-parietal adhesions was noted in the SRM series: in the groups PP Light, TiMesh, and Titan it was equal to 0.36, 0.44, and 0.50 points, respectively. In some cases the zone of repair was completely free of adhesions. Adhesive process in the IPOM series should be considered unacceptably intensive in all periods for all tested meshes. In the SRM series, opposite (the best) results have been obtained, which were comparable for all types of meshes used in the work. Safety of retromuscular repair using ultra-lightweight synthetic and titanium-containing meshes has been convincingly proved by the data of the experiment.Conclusion. Retromuscular repair with ultra-lightweight synthetic and titanium-containing meshes should be used for the reconstruction of the abdominal wall. But application of titanium-containing meshes seem to be more preferable, as it is associated with formation of significantly more strong connective tissue in the implantation zone, and an inflammatory reaction induced by such a mesh is substantially less than by a synthetic one.

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“…On the territory of Russia and eastern countries, titanium mesh implants made of ultrathin titanium filaments have become common. A number of experimental studies have shown their advantages compared with polymer mesh implants (Parshikov, Kazantsev, et al, 2016; Parshikov, Mironov, et al, 2016; Kazantsev et al, 2016; Ovchinnikov, Uchevatkina, Kurbatova, Lukyanenko, & Yakutina, 2019). Currently, titanium mesh implants for hernia repair are being studied in clinical trials.…”

Section: Introductionmentioning

confidence: 99%

Computed tomography options in the evaluation of hernia repair outcomes using “titanium silk” mesh implants

Shemyatovsky

Azimov

Alekhin

et al. 2020

J Tissue Eng Regen Med

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Background: According to experimental studies, mesh implants may reduce in size up to 50.8% during their integration into soft tissues. This results in impaired mobility of the anterior abdominal wall and hernia recurrences, as well as affects patients' quality of life. Due to unsatisfactory radiographic contrast of polymeric mesh implants, changes in their size can be rarely confirmed using imaging methods. Medical devices made of metal alloys have the best radiographic contrast. Objective: The purpose of this study was to evaluate the radiographic contrast of mesh implants made of titanium filaments and to determine the sizes and locations of the implants after the anterior abdominal wall hernia repair. Materials & Methods: The study included 40 patients with inguinal, umbilical, and postoperative ventral hernias. Surgical hernia repair was performed using a mash implant made of titanium filaments, "titanium silk". Multislice spiral computed tomography (MSCT) was performed on Days 3 and 90 after surgery, followed by an assessment of the size and location of the mesh implant.Results: 90 days after the anterior abdominal wall hernia repair, the locations of the titanium silk mesh implants in the tissues corresponded to their intraoperative setting. There were no statistically significant changes in the sizes of mesh implants on Day 90, compared with Day 3. Conclusion:The titanium silk mesh implants have satisfactory radiographic contrast, which allows imaging of their location and size in the tissues using MSCT and comprehensive evaluation of hernia repair outcomes using instrumental methods of examination. K E Y W O R D S3D reconstruction, multislice spiral computed tomography, polymeric mesh implants, radiographic contrast, soft tissues, titanium mesh

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The titanium-containing mesh as a perspective group of implants for abdominal wall repair

Cited by 4 publications

References 44 publications

Surgical correction of prolapse of anterior wall of the vagina and cervix using titanium mesh implants

Surgical correction of prolapse of anterior wall of the vagina and cervix using titanium mesh implants

Visceral Adhesions after Tension-Free Abdominal Wall Repair with Ultra-Lightweight Synthetic and Titanium-Containing Meshes

Computed tomography options in the evaluation of hernia repair outcomes using “titanium silk” mesh implants

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