The Time Pattern of Selenomethionine Administration in Preventing Free Radicals Due to Exposure to Electric Cigarette Smoke

Abstract

Background: Most people believe that electric cigarettes have no negative effect on health, which causes them to use it more. However, exposure to the smoke from these cigarettes is bad for the health and causes cell damage. Antioxidants play an important role in preventing cell damage, and they can be obtained through the oral administration of selenomethionine.Design and methods: This study used an experimental method and a post-test control group design. Male Wistar rats, which were exposed to cigarette smoke were given selenomethionine orally and then tested for the presence of free radicals. The measurement of lung tissue damage was conducted by assessing the level of malondialdehyde in the blood and immunohistochemistry (IHC) of the lung tissue.Result: The study showed that differences in the time of administration of selenomethionine affect the levels of malondialdehyde in the blood and expression of malondialdehyde in the lung tissue (p<0.05). Consequently, the two groups showed a strong (r=0.861) and significant (p=0.000) relationship with each other.Conclusion: The early application of selenomethionine can prevent increased levels of malondialdehyde in the blood and lung tissue due to exposure to e-cigarette smoke.

E-cigarette aerosol exacerbates cardiovascular oxidative stress in mice with an inactive aldehyde dehydrogenase 2 enzyme

“…Our study highlights the role of aldehyde metabolism in e-cigarette-induced oxidative stress and importantly identifies that inefficient aldehyde metabolism, as for the ALDH2*2 mice, causes higher levels of oxidative stress relative to wild type ALDH2 mice. Other studies also report e-liquid can generate the reactive aldehyde MDA [ [45] , [46] , [47] ]. In addition, we observed that acetaldehyde as the primary aldehyde in e-cigarette aerosol promotes intracellular Ca 2+ influx, with the ALDH2*2 variant further enhanceing the Ca 2+ influx.…”

<em>Brassica oleracea</em> var. italica extract reducing free radicals and inflammation initiated by an exposure to cigarette smoke

“…33,34 This vegetable also contains selenium, and is known to potentially increase various enzymatic antioxidants, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). 35…”

Relationship of Knowledge and Perception of Self-Medication of Cough Medicine to Lung Function Disorders in Construction Workers in Indonesia

“…Products exposed to cigarette smoke can cause a prolonged inflammatory response that damages the epithelium of the airways and lung tissue, reduces lung defense mechanisms, and interferes with tissue repair in the lungs. [11][12][13] As frequent smoking can cause symptoms such as dyspnea, increased sputum production, and coughing, these symptoms can be early detection of pulmonary function disorders, namely COPD. 14 Of the symptoms that commonly occur, cough is one of the risk factors for pulmonary function disorders, namely COPD, especially in chronic cough in smokers.…”