The time course of nasal cytokine secretion in patients with aspirin-exacerbated respiratory disease (AERD) undergoing aspirin desensitization: preliminary data

Nicoló, Marion San; Högerle, Catalina; Gellrich, Donata; Eder, Katharina; Pfrogner, Elisabeth; Gröger, Moritz

doi:10.1007/s00405-019-05704-1

Cited by 5 publications

(11 citation statements)

References 35 publications

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“…New insights in the immunological mechanism and pathophysiology of AERD are currently an active field of research. Indeed, nasal polyposis is characterized by a T H 2 dominated milieu, producing IL-4 and IL-5 as well as the ECP and eotaxin [5,8]. Therapy with biologicals, specifically addressing those immunological processes, show promising results [37][38][39][40].…”

Section: Discussionmentioning

confidence: 99%

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AERD Associated Nasal Polyposis: Efficacy of Postoperative Antileukotriene Therapy in Comparison with Aspirin Desensitization. A Retrospective Study

Nicoló

Habermann

Havel

2020

Int Arch Allergy Immunol

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Introduction: AERD (aspirin-exacerbated respiratory disease) is a severe form of an inflammatory disease of the upper airway system. Therapy remains challenging due to a complex underlying pathophysiology. Objective: To evaluate the efficacy of postoperative antileukotriene therapy concerning recurrence of nasal polyposis in patients with AERD and to compare it with AD (aspirin desensitization) over time. Methods: In this retrospective study we analyzed AERD patients (N = 61) after functional endoscopic sinus surgery (FESS). Patients were treated at our institution postoperatively with topical mometasone (control group, N = 22), leukotriene-receptor-antagonists (montelukast [MT], N = 18) or underwent an aspirin desensitization (N = 21). Subjective parameters as assessed by SNOT (sinonasal outcome test) questionnaire and endoscopic endonasal examination (polyposis grading) were evaluated throughout a follow-up period of 6-9 and >12 (long-term) months after surgery. Results: Endoscopic endonasal examinations 6-9 months after sinus surgery showed a good disease control in all 3 groups with significant reduction in polyp grading in the AD group. After a follow-up period of more than 12 months, MT and AD patients had significantly less polyp recurrences as compared to the topical treatment group. Subjective sinonasal symptoms revealed that hyposmia and nasal obstruction were prominent factors in all 3 groups throughout the follow-up period. MT group showed significant improvement in sinonasal symptoms over time. Conclusion: Postoperative treatment with leukotriene-receptor-antagonists and aspirin desensitization both significantly reduce nasal polyp recurrence. MT has a positive effect on subjective sinonasal outcomes and patients' quality of life over time.

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Section: Discussionmentioning

confidence: 99%

“…Chronic rhinosinusitis with nasal polyps (CRSwNP) is generally characterized by a dominant eosinophilic, T H 2 dominated reaction [6][7][8]. This eosinophilic pro-inflammatory milieu leads to oedematous stroma with subepithelial and perivascular infiltration of inflammatory cells [5].…”

Section: Introductionmentioning

confidence: 99%

AERD Associated Nasal Polyposis: Efficacy of Postoperative Antileukotriene Therapy in Comparison with Aspirin Desensitization. A Retrospective Study

Nicoló

Habermann

Havel

2020

Int Arch Allergy Immunol

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Section: Nasal Mucus Collection Methodsmentioning

confidence: 99%

“…Since it is easily accessible and generally nontraumatic, placement of cotton wool was among the first collection methods for CRS-related research and reproduced several times since. [17][18][19][20][21][22]52,56 Though not as common due to expenses from proprietary technology, Leukosorb (Pall Scientific, Port Washington, NY) is another noninvasive filter paper with an excellent ability to limit dilution of soluble biomarkers, particularly from the olfactory cleft (OC), and withstand degradation in freezing or room temperature storage for at least 24 h. 2,45,60 Absorbent sponges (ie, polyvinyl alcohol sponge, polyurethane sponge) have also served as reliable collection methods. 10,[23][24][25][26][27][28][29][30][31][32]61 A 2004 study by Watelet et al, 23 showed that absorbent sinus packs (IVALON 4000Plus, comprised of polyvinyl alcohol) yielded excellent mucus volume and protein recovery in vitro and in subsequent human models (control vs CRSwNP).…”

Section: Nasal Mucus Collection Methodsmentioning

confidence: 99%

Utilization of Nasal Mucus to Investigate the Pathophysiology of Chronic Rhinosinusitis

Parra-Ferro

Justice

Lobo

et al. 2022

Am J Rhinol�Allergy

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Background Nasal mucus is proving to be a useful means by which to study the pathogenesis of chronic rhinosinusitis (CRS). Given the increase in publications examining nasal mucus and the lack of a review on this topic, we will focus on this noninvasive approach to studying CRS. Particular attention will be drawn towards inflammatory cytokines and biomarkers and their influence on disease severity. Methods A literature review of papers published in English pertaining to nasal mucus was performed using the PubMed database. The search utilized combinations of the following keywords: sinusitis, polyps, sample collection, nasal mucus, or nasal secretion. Studies solely on acute or bacterial sinusitis, allergic rhinitis, or cystic fibrosis were not included. Results A wide variety of materials and methods have been used to collect nasal mucus. Numerous assay types have been performed with the most common being ELISA, cytometric bead array, and proteomics. Most studies have focused on examining the levels of Th1/Th2 cytokines along with chemokines associated with type 2 immunity. Other factors identified include growth factors, senescence-associated proteins, complement, and antimicrobial defenses have also been identified. Nasal mucus cytokines have proven useful in cluster analysis and predicting postoperative improvement in Sino-nasal Outcome Test (SNOT-22) scores. One limitation of the use of nasal mucus is that some studies have suggested that nasal mucus does not always reflect the tissue microenvironment. Conclusions Nasal mucus represents a critical tool by which to examine the sinonasal microenvironment in a noninvasive manner. Unlike studies of tissue, it can be utilized in both surgically and medically managed patients and avoids the trauma of biopsies. However, studies are still needed to determine the most effective method for nasal mucus collection. Studies should also take care to confirm that nasal mucus markers do, in fact, reflect the levels of the product studied in the tissue.

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“…Two studies on AERD described mixed inflammatory endotype shifts, T1/2/3 and T2/3. 41,42 Scott et al 41 demonstrated a shift to the T1/2/3 endotype through significant elevations in type 1 (IFN-γ) and type 2 (IL-5 and IL-13) cytokines. San Nicol o et al 42 demonstrated a T2/3 endotype, which shared with Scott et al 41 elevations in type 2 cytokines and the type 3 cytokine: IL-17.…”

Section: Endotypes In Comorbid Chronic Rhinosinusitis and Lower Airwa...mentioning

confidence: 99%

Non‐Type 2 and Mixed Inflammation in Chronic Rhinosinusitis and Lower Airway Disease

Heffernan,

Shafiee,

Chan

et al. 2023

The Laryngoscope

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ObjectiveThe aim was to discuss the role of non‐type 2 inflammation in patients diagnosed with chronic rhinosinusitis (CRS) and comorbid lower airway disease.Data SourcesMedline, Embase, National Institute for Health and Care Excellence, TRIP Database, ProQuest, Clinicaltrials.gov, Cochrane Central Registry of Controlled Trials, Web of Science, government and health organizations, and graduate‐level theses.Review MethodsThis scoping review followed PRISMA‐ScR guidelines. Search strategy was peer‐reviewed by medical librarians. Studies were included if they utilized airway sampling, non‐type 2 cytokines, and patients with CRS and lower airway disease.ResultsTwenty‐seven from 7060 articles were included. In patients with CRS and comorbid asthma, aspirin‐exacerbated respiratory disease (AERD), and chronic obstructive pulmonary disease (COPD)/bronchiectasis, 60% (n = 12), 33% (n = 2), and 100% (n = 1), respectively, demonstrated mixed or non‐type 2 endotypes. Comorbid CRS and asthma produced type 1 (n = 1.5), type 2 (n = 8), type 3 (n = 1), mixed type 1/2 (n = 1), and mixed type 1/2/3 (n = 8.5) endotype shifts. AERD demonstrated type 2 (n = 4), mixed type 2/3 (n = 1), and mixed type 1/2/3 (n = 1) endotype shifts. CRS with COPD or bronchiectasis demonstrated a mixed 1/2 (n = 1) endotype shift.ConclusionType 2 disease has been extensively reviewed due to advent biologics targeting type 2 inflammation, but outcomes may be suboptimal due to the presence of non‐type 2 inflammation. A proportion of patients with CRS and comorbid lower airway disease demonstrated mixed and non‐type 2 endotype shifts. This emphasizes that patients with unified airway disease may have forms of inflammation beyond classical type 2 disease which could inform biologic development. Laryngoscope, 2023

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The time course of nasal cytokine secretion in patients with aspirin-exacerbated respiratory disease (AERD) undergoing aspirin desensitization: preliminary data

Cited by 5 publications

References 35 publications

AERD Associated Nasal Polyposis: Efficacy of Postoperative Antileukotriene Therapy in Comparison with Aspirin Desensitization. A Retrospective Study

AERD Associated Nasal Polyposis: Efficacy of Postoperative Antileukotriene Therapy in Comparison with Aspirin Desensitization. A Retrospective Study

Utilization of Nasal Mucus to Investigate the Pathophysiology of Chronic Rhinosinusitis

Non‐Type 2 and Mixed Inflammation in Chronic Rhinosinusitis and Lower Airway Disease

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