The time course of functional alterations in degenerating dorsal column afferents to lateral cuneate nucleus

Ultrastructural changes in acetylcholinesterase activity in the deafferented spinal trigeminal nucleus

“…As discussed by Loeser and Howe (1980), this response is also documented in other deafferented systems including dorsal horn (Loeser and Ward, 1967) and the lateral cuneate nucleus (LCN) (Kjerulf and Loeser, 1973). Howe and Loeser (1973) show that the time course of neuronal hyperactivity following dorsal funiculotomy in the LCN correlates with the loss of synaptic contacts and not with the loss of normal tonic afferent input. Moreover, synaptic reorganization, specifically resulting in F terminals occupying denuded type I contacts, occurs concomitantly with the development of neuronal hyperactivity in the spinal trigeminal nucleus (Westrum, 1980).…”