The tight junction protein claudin-1 influences cranial neural crest cell emigration

Fishwick, Katherine; Neiderer, Theresa E.; Jhingory, Sharon; Bronner‐Fraser, Marianne; Taneyhill, Lisa A.

doi:10.1016/j.mod.2012.06.006

Cited by 18 publications

(17 citation statements)

References 49 publications

(69 reference statements)

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“…Claudin 1 is expressed in chick premigratory neural crest, but is downregulated during the neural crest migration. Morpholino-mediated loss of Cldn1 expression resulted in earlier and more extensive neural crest migration, consistent with the proposed role of Cldn1 is stabilizing the intercellular tight junctions in the dorsal neural tube (Fishwick et al, 2012). The significance of Cldn18 expression in the lamprey migrating neural crest is not clear at present and requires further investigation.…”

Section: Fig 11 Loss Of Claudin 3b Results In Pharyngeal Arch and Osupporting

confidence: 62%

“…In chick, claudin 18 expression has been reported in Hensen's node, epiblast, neural and non-neural ectoderm, pharynx, eye and limb ectoderm, but not in the migrating neural crest (Collins et al, 2013). So far, there has only been a single report of any involvement of a claudin (Cldn 1) in neural crest development (Fishwick et al, 2012). Claudin 1 is expressed in chick premigratory neural crest, but is downregulated during the neural crest migration.…”

Section: Fig 11 Loss Of Claudin 3b Results In Pharyngeal Arch and Omentioning

confidence: 99%

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Evolution of the vertebrate claudin gene family: insights from a basal vertebrate, the sea lamprey

Mukendi

Dean²,

Lala³

et al. 2016

Int. J. Dev. Biol.

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Claudins are major constituents of tight junctions, contributing both to their intercellular sealing and selective permeability properties. While claudins and claudin-like molecules are present in some invertebrates, the association of claudins with tight junctions has been conclusively documented only in vertebrates. Here we report the sequencing, phylogenetic analysis and comprehensive spatiotemporal expression analysis of the entire claudin gene family in the basal extant vertebrate, the sea lamprey. Our results demonstrate that clear orthologues to about half of all mammalian claudins are present in the lamprey, suggesting that at least one round of whole genome duplication contributed to the diversification of this gene family. Expression analysis revealed that claudins are expressed in discrete and specific domains, many of which represent vertebratespecific innovations, such as in cranial ectodermal placodes and the neural crest; whereas others represent structures characteristic of chordates, e.g. pronephros, notochord, somites, endostyle and pharyngeal arches. By comparing the embryonic expression of claudins in the lamprey to that of other vertebrates, we found that ancestral expression patterns were often preserved in higher vertebrates. Morpholino mediated loss of Cldn3b demonstrated a functional role for this protein in placode and pharyngeal arch morphogenesis. Taken together, our data provide novel insights into the origins and evolution of the claudin gene family and the significance of claudin proteins in the evolution of vertebrates.

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Section: Fig 11 Loss Of Claudin 3b Results In Pharyngeal Arch and Osupporting

confidence: 62%

Section: Fig 11 Loss Of Claudin 3b Results In Pharyngeal Arch and Omentioning

confidence: 99%

Evolution of the vertebrate claudin gene family: insights from a basal vertebrate, the sea lamprey

Mukendi

Dean²,

Lala³

et al. 2016

Int. J. Dev. Biol.

Self Cite

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“…Our data are comparable to those reported in the literature [62][63][64][65] and suggest better tight junction formation in the differentiated CE sphere progenies than primary CE cells. In fact, it was found that tight junction proteins such as ZO-1 and claudin-1 were downregulated as neural crest cells differentiate [66,67]. Besides, the densities of Na + /K + ATPase pump sites in the CE cells were found to increase as the CE become more mature [68].…”

Section: Discussionmentioning

confidence: 99%

Bovine Posterior Limbus: An Evaluation of an Alternative Source for Corneal Endothelial and Trabecular Meshwork Stem/Progenitor Cells

Grierson

Sheridan

et al. 2015

Stem Cells and Development

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A growing body of evidence has revealed that stem-like cells in the posterior limbus of the eye between the corneal endothelium (CE) and trabecular meshwork (TM) may be able to rejuvenate these tissues in disease. However, these cells have not been clearly defined and we have named them PET cells (progenitor cells of the endothelium and trabeculum). A good and inexpensive animal model for PET cells is lacking, so we investigated bovine eyes as an effective large tissue source. We showed the presence of stem/progenitor cells in the bovine CE, transition zone, and TM in situ. Floating spheres cultured from the CE and TM showed similar stem cell marker expression patterns. Both the CE and TM spheres were bipotent and highly proliferative, but with limited secondary sphere-forming capability. They were highly prone to differentiate back into the cell type of their tissue of origin. It is speculated that the PET cells become more tissue-specific as they migrate away from their niche. Here, we showed that PET cells are present in the posterior limbus of bovine eyes and that they can be successfully cultured and expanded. PET cells represent an attractive target for developing new treatments to regenerate both the CE and TM, thereby reducing the requirement for donor tissue for corneal transplant and invasive treatments for glaucomatous patients.

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“…As a pseudo-stratified epithelium, the neural tube (and premigratory neural crest cells) possesses specific junctional complexes to maintain this epithelial state. These include both tight and adherens junctions ((Fishwick et al, 2012; Wu et al, 2011); reviewed in (Duband et al., 2015; Taneyhill and Schiffmacher, 2013)), along with the appropriate intracellular molecules, such as Rho family GTPases, that render these cells immotile (reviewed in (Kalcheim, 2015; Taneyhill and Padmanabhan, 2013)).…”

Section: A Formation Of the Neural Crestmentioning

confidence: 99%

Should I stay or should I go? Cadherin function and regulation in the neural crest

Taneyhill

Schiffmacher

2017

Genesis

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Our increasing comprehension of neural crest cell development has reciprocally advanced our understanding of cadherin expression, regulation, and function. As a transient population of multipotent stem cells that significantly contribute to the vertebrate body plan, neural crest cells undergo a variety of transformative processes and exhibit many cellular behaviors, including epithelial-to-mesenchymal-transition (EMT), motility, collective cell migration, and differentiation. Multiple studies have elucidated regulatory and mechanistic details of specific cadherins during neural crest cell development in a highly contextual manner. Collectively, these results reveal that gradual changes within neural crest cells are accompanied by often times subtle, yet important, alterations in cadherin expression and function. The primary focus of this review is to coalesce recent data on cadherins in neural crest cells, from their specification to their emergence as motile cells soon after EMT, and to highlight the complexities of cadherin expression beyond our current perceptions, including the hypothesis that the neural crest EMT is a transition involving a predominantly singular cadherin switch. Further advancements in genetic approaches and molecular techniques will provide greater opportunities to integrate data from various model systems in order to distinguish unique or overlapping functions of cadherins expressed at any point throughout the ontogeny of the neural crest.

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The tight junction protein claudin-1 influences cranial neural crest cell emigration

Cited by 18 publications

References 49 publications

Evolution of the vertebrate claudin gene family: insights from a basal vertebrate, the sea lamprey

Evolution of the vertebrate claudin gene family: insights from a basal vertebrate, the sea lamprey

Bovine Posterior Limbus: An Evaluation of an Alternative Source for Corneal Endothelial and Trabecular Meshwork Stem/Progenitor Cells

Should I stay or should I go? Cadherin function and regulation in the neural crest

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