Should I stay or should I go? Cadherin function and regulation in the neural crest

Taneyhill, Lisa A.; Schiffmacher, Andrew T.

doi:10.1002/dvg.23028

Cited by 50 publications

(44 citation statements)

References 174 publications

(289 reference statements)

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“…Cell adhesion proteins have long been studied for their role in the process of NC EMT (reviewed in Barriga & Mayor, 2015; Strobl-Mazzulla & Bronner, 2012a; Taneyhill & Schiffmacher, 2017); however, recent analyses have determined that these proteins may also have additional roles in NC specification and induction. Recent evidence has determined that NC specifiers and EMT-inducing factors like SNAI2 have alternate early roles in cell fate specification.…”

Section: | Signaling Events Regulating Nc Inductionmentioning

confidence: 99%

Specifying neural crest cells: From chromatin to morphogens and factors in between

Rogers

Nie

2018

WIREs Developmental Biology

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Neural crest (NC) cells are a stem-like multipotent population of progenitor cells that are present in vertebrate embryos, traveling to various regions in the developing organism. Known as the "fourth germ layer", these cells originate in the ectoderm between the neural plate (NP), which will become the brain and spinal cord, and nonneural tissues that will become the skin and the sensory organs. NC cells can differentiate into more than 30 different derivatives in response to the appropriate signals including, but not limited to, craniofacial bone and cartilage, sensory nerves and ganglia, pigment cells, and connective tissue. The molecular and cellular mechanisms that control the induction and specification of NC cells include epigenetic control, multiple interactive and redundant transcriptional pathways, secreted signaling molecules, and adhesion molecules. NC cells are important not only because they transform into a wide variety of tissue types, but also because their ability to detach from their epithelial neighbors and migrate throughout developing embryos utilizes mechanisms similar to those used by metastatic cancer cells. In this review, we discuss the mechanisms required for the induction and specification of NC cells in various vertebrate species, focusing on the roles of early morphogenesis, cell adhesion, signaling from adjacent tissues, and the massive transcriptional network that controls the formation of these amazing cells. This article is categorized under: Nervous System Development > Vertebrates: General Principles Gene Expression and Transcriptional Hierarchies > Regulatory Mechanisms Gene Expression and Transcriptional Hierarchies > Gene Networks and Genomics Signaling Pathways > Cell Fate Signaling.

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Section: | Signaling Events Regulating Nc Inductionmentioning

confidence: 99%

Specifying neural crest cells: From chromatin to morphogens and factors in between

Rogers

Nie

2018

WIREs Developmental Biology

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“…Notably, this ADAM10‐dependent proteolytic event is triggered by BMP activity (Shoval et al, ) (Figure ). Subsequent studies confirmed and extended these findings implicating ADAM‐dependent proteolysis of N‐cadherin, cadherin 6B, and cadherin 11 in the onset of NC EMT at cranial levels of the axis (Alfandari et al, ; McCusker, Cousin, Neuner, & Alfandari, ; Monsonego‐Ornan et al, ; Schiffmacher et al, ) and reviewed in (Taneyhill & Schiffmacher, ).…”

Section: The Dynamics Of Nc Emt In the Trunkmentioning

confidence: 80%

Neural crest emigration: From start to stop

Kalcheim

2018

Genesis

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Within the dynamic context of a developing embryo, the multicellular patterns formed are extraordinarily precise. Through cell-cell communication, neighboring progenitors coordinate their activities, sequentially generating distinct tissues. The development of the dorsal neural tube remarkably illustrates this principle. It first generates neural crest (NC) cells, precursors of most of the peripheral nervous system, and then becomes the roof plate (RP) of the central nervous system. While the molecular network regulating emigration of NC progenitors has been extensively studied, the mechanisms by which dorsal neural tube precursors transit from an initial NC fate to a definitive RP identity remain widely open to investigation. Critical differences exist between premigratory NC and RP cells. Whereas the former extensively proliferate and undergo an epithelial-to-mesenchymal transition that generates cellular migrations, the latter progressively exit the cell cycle and regain epithelial traits including apico-basal polarity and regeneration of a laminin-containing basement membrane. To understand this transition, the nature of the cross-talk between these two sequentially forming progenitor subsets should be unraveled, including the identity and mode of action of signals that, on the one hand, induce the arrest of NC emigration, and, on the other hand, promote formation of a definitive RP.

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“…Many cadherins have been implicated in NC EMT; please see Taneyhill and Schiffmacher (2017) for a thorough review of this topic. Here, we will focus specifically on E-cadherin and N-cadherin’s relevance to both the NC and cancer.…”

Section: Delamination and Epithelial-mesenchymal Transition (Emt)mentioning

confidence: 99%

Neural crest and cancer: Divergent travelers on similar paths

Gallik

Treffy

Nacke

et al. 2017

Mechanisms of Development

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Neural crest cells are multipotent progenitors that dynamically interpret diverse microenvironments to migrate significant distances as a loosely associated collective and contribute to many tissues in the developing vertebrate embryo. Uncovering details of neural crest migration has helped to inform a general understanding of collective cell migration, including that which occurs during cancer metastasis. Here, we discuss several commonalities and differences of neural crest and cancer cell migration and behavior. First, we focus on some of the molecular pathways required for the initial specification and potency of neural crest cells and the roles of many of these pathways in cancer progression. We also describe epithelial-to-mesenchymal transition, which plays a critical role in initiating both neural crest migration and cancer metastasis. Finally, we evaluate studies that demonstrate myriad forms of cell-cell and cell-environment communication during neural crest and cancer collective migration to highlight the remarkable similarities in their molecular and cell biological regulation.

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Should I stay or should I go? Cadherin function and regulation in the neural crest

Cited by 50 publications

References 174 publications

Specifying neural crest cells: From chromatin to morphogens and factors in between

Specifying neural crest cells: From chromatin to morphogens and factors in between

Neural crest emigration: From start to stop

Neural crest and cancer: Divergent travelers on similar paths

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