The Thyroid Gland

Patterns of expression of cytoskeletal proteins in human thyroid gland and thyroid carcinomas

“…[55], we did not see cells expressing cytokeratin 10, nor did we detect any of the other stratification-related cytokeratins, such as components 4, 13, 14, and 17 in our cases, which is at variance with other reports ( [16,79,811; see the foregoing discussion of the limited information on the antibodies used in these studies). Noteworthy, we have not had access to papillary carcinomas that contain regions of squamous differentiation, and this could as well explain the difference.…”

“…V , vimentin (including material from contaminating connective tissues, stromal cells, and blood vessels ; in b, degradation products of vimentin are denoted by arrowheads). In addition, various cytoskeletal-protein markers have been applied in immunocytochemistry to identify and differentiate the different kinds of thyroid tumors, albeit with partly controversial results [5,16,17,52,53,55,79,81,85,97,102,108,110,118,. a Normal thyroid gland, showing cytokeratins 7 and 8, and a small (hardly detectable) amount of cytokeratin 18 ; the brackets denote two consistently observed, insoluble proteins, possibly nuclear lamins A and C; Coomassie blue staining.…”

Effects of Thyrotropin-Releasing Hormone and a Thyrotropin Releasing Hormone Analog on Growth and Selected Plasma Hormones in Lambs

“…Plasma T3 and T4 remained elevated in this study despite the return of plasma TSH to normal levels after 10 d of TRH or <Aad-His-Pro-NH2 infusion. A hypothesis to explain these observations is that the initial elevation of TSH caused the growth of the thyroid gland (Burgi and Labhart, 1974). The enlarged thyroid gland produced more T 4 (and T3) which, in turn, partially inhibited the secretion of TSH by the pituitary gland (Burgi and Labhart, 1974).…”

“…A hypothesis to explain these observations is that the initial elevation of TSH caused the growth of the thyroid gland (Burgi and Labhart, 1974). The enlarged thyroid gland produced more T 4 (and T3) which, in turn, partially inhibited the secretion of TSH by the pituitary gland (Burgi and Labhart, 1974). The enlargement of the thyroid glands persisted through the remainder of the trial (102 and 70% increases in thyroid gland weights for TRH-and <Aad-His-Pro-NH2infused lambs, respectively) and accounted for the continued elevation of T3 and T4.…”

Thyrotoxic neuropathy (Basedow's paraplegia).

“…The precise mode of action of this drug is unknown (Burgi and Labhart, 1974), but no direct neurotoxic effect has been described. However, adverse sideeffects, including agranulocytosis, are well known (McGavack and Chevalley, 1954).…”