The Therapeutic Potential of Kaemferol and Other Naturally Occurring Polyphenols Might Be Modulated by Nrf2-ARE Signaling Pathway: Current Status and Future Direction

Hussain, Yaseen; Khan, Haroon; Alsharif, Khalaf F.; Khan, Amjad; Aschner, Michael; Saso, Luciano

doi:10.3390/molecules27134145

Cited by 13 publications

(5 citation statements)

References 116 publications

(108 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alkaloids have muscle relaxant, antioxidant, anticancer, antimicrobial and amoebicidal properties [ 49 ]. Kaempferol has been widely used in treating cancer, cardiovascular diseases, metabolic complications, and neurological disorders [ 50 ]. Quercetin is another flavonoid with a wide variety of biological activities, such as antioxidant, broad-spectrum antibacterial and antiparasitic properties, cardiovascular protection, anti-immunosuppression treatment, and reduce the toxicity of mycotoxins [ 51 ], while rutin has been reported as a strong antioxidant with cancer preventive properties [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

The Antimethanogenic Potentials of Plant Extracts: Their Yields and Phytochemical Compositions as Affected by Extractive Solvents

Ibrahim

Hassen

Apostolides

2022

Plants

View full text Add to dashboard Cite

Plant phytochemicals are an important area of study in ruminant nutrition, primarily due to their antimethanogenic potentials. Plant extract yields, their bioactive compounds and antimethanogenic properties are largely dependent on the nature of the extractive solvents. This study evaluated the yields and phytochemical constituents of four plant extracts, as affected by the aqueous-methanolic (H2O-CH3OH) extraction and their antimethanogenic properties on the in vitro methane production. The plant extracts included Aloe vera, Jatropha curcas, Moringa oleifera, and Piper betle leaves with three levels of extractions (70, 85, and 100% CH3OH). The crude plant extract yields increased with the increasing amount of water. M. oleifera crude extracts yields (g/10 g) increased from 3.24 to 3.92, A. vera, (2.35 to 3.11) J. curcas (1.77 to 2.26), and P. betle (2.42 to 3.53). However, the identified and quantified metabolites showed differing degrees of solubility unique to their plant leaves in which they exist, while some of the metabolites were unaffected by the extraction solvents. The methane mitigating potentials of these extracts were evaluated as additives on Eragrostis curvula hay at a recommended rate of 50 mg kg−1 DM. The plant extracts exhibited antimethanogenic properties to various degrees, reducing (p < 0.05) in vitro methane production in the tested hay, A. vera, J. curcas, M. oleifera and P. betle reduced methane emission by 6.37–7.55%, 8.02–11.56%, 12.26–12.97, and 5.66–7.78 respectively compared to the control treatment. However, the antimethanogenic efficacy, gas production and organic matter digestibility of the plant extracts were unaffected by the extraction solvents. Metabolites, such as aloin A, aloin B and kaempferol (in A. vera), apigenin, catechin, epicatechin, kaempferol, tryptophan, procyanidins, vitexin-7-olate and isovitexin-7-olate (in J. curcas), alkaloid, kaempferol, quercetin, rutin and neochlorogenic acid (in M. oleifera) and apigenin-7,4′-diglucoside, 3-p-coumaroylquinic acid, rutin, 2-methoxy-4-vinylphenol, dihydrocaffeic acid, and dihydrocoumaric acid (in P. betle) exhibited a methane reducing potential and hence, additional studies may be conducted to test the methane reducing properties of the individual metabolites as well as their combined forms. Plant extracts could be more promising, and hence, further study is necessary to explore other extraction methods, as well as the encapsulation of extracts for the improved delivery of core materials to the target sites and to enhance methane reducing properties. Furthermore, the use of 70% aqueous extraction on M. oleifera leaf is recommended for practical use due to the reduced cost of extractive solvents, the lower cost and availability of Moringa plants in South Africa, especially in Gauteng Province. Furthermore, 70% aqueous-methanolic extractions of A. vera, J. curcas, and P. betle are recommended for practical use in regions where they exist in abundance and are cost effective.

show abstract

Section: Resultsmentioning

confidence: 99%

The Antimethanogenic Potentials of Plant Extracts: Their Yields and Phytochemical Compositions as Affected by Extractive Solvents

Ibrahim

Hassen

Apostolides

2022

Plants

View full text Add to dashboard Cite

show abstract

“…Many compounds such as curcumin, sulforaphane, resveratrol, and 3,3′-diindolylmethane can protect cells from inflammation and OS by mediating the Nrf2 defense response and stimulating phase II detoxification enzymes, transporters, and antioxidants, which is effective in preventing further damage [ 16 , 124 , 132 , 135 , 136 , 137 , 138 , 139 , 140 ].…”

Section: Nrf2 Signaling Pathwaymentioning

confidence: 99%

Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review

et al. 2023

View full text Add to dashboard Cite

Inflammatory bowel diseases (IBDs) are related to nuclear factor erythroid 2-related factor 2 (Nrf2) dysregulation. In vitro and in vivo studies using phytocompounds as modulators of the Nrf2 signaling in IBD have already been published. However, no existing review emphasizes the whole scenario for the potential of plants and phytocompounds as regulators of Nrf2 in IBD models and colitis-associated colorectal carcinogenesis. For these reasons, this study aimed to build a review that could fill this void. The PubMed, EMBASE, COCHRANE, and Google Scholar databases were searched. The literature review showed that medicinal plants and phytochemicals regulated the Nrf2 on IBD and IBD-associated colorectal cancer by amplifying the expression of the Nrf2-mediated phase II detoxifying enzymes and diminishing NF-κB-related inflammation. These effects improve the bowel environment, mucosal barrier, colon, and crypt disruption, reduce ulceration and microbial translocation, and consequently, reduce the disease activity index (DAI). Moreover, the modulation of Nrf2 can regulate various genes involved in cellular redox, protein degradation, DNA repair, xenobiotic metabolism, and apoptosis, contributing to the prevention of colorectal cancer.

show abstract

“…It is a yellow, crystalline powder that is only moderately soluble in water. Kaempferol's antioxidant and anti-cancer properties have received extensive research attention (Hussain et al, 2022). According to scientific research, Kaempferol may be an effective natural chemo-sensitizer and anti-tumor agent against lung cancer (Fouzder et al, 2021).…”

Section: Kaempferolmentioning

confidence: 99%

Modulation of carcinogenesis with selected GRAS nutraceuticals via Keap1‐Nrf2 signaling pathway

Nair,

Adithya,

Chandrababu

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

Keap1‐Nrf2 is a fundamental signaling cascade known to promote or prevent carcinogenesis. Extensive studies identify the key target of modulatory aspects of Keap1‐Nrf2 signaling against cancer. Nutraceuticals are those dietary agents with many health benefits that have immense potential for cancer chemoprevention. The nutritional supplements known as nutraceuticals are found to be one of the most promising chemoprevention agents. Upon investigating the dual nature of Nrf2, it became clear that, in addition to shielding normal cells from numerous stresses, Nrf2 may also promote the growth of tumors. In the present review, we performed a systematic analysis of the role of 12 different nutraceuticals like curcumin, sulforaphane, resveratrol, polyunsaturated fatty acids (PUFA) from fish oil, lycopene, soybean, kaempferol, allicin, thymoquinone, quercetin, gingerol, and piperine in modulating the Nrf2/Keap1 signaling mechanism. Among these, 12 Generally Recognized As Safe (GRAS) certified nutraceuticals, sulforaphane is the most extensively studied compound in modulating Keap1‐Nrf signaling. Even though there is much evidence at preclinical levels, further high‐quality research is still required to validate the potential role of these nutraceuticals in Keap1‐Nrf2 modulation.

show abstract

The Therapeutic Potential of Kaemferol and Other Naturally Occurring Polyphenols Might Be Modulated by Nrf2-ARE Signaling Pathway: Current Status and Future Direction

Cited by 13 publications

References 116 publications

The Antimethanogenic Potentials of Plant Extracts: Their Yields and Phytochemical Compositions as Affected by Extractive Solvents

The Antimethanogenic Potentials of Plant Extracts: Their Yields and Phytochemical Compositions as Affected by Extractive Solvents

Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review

Modulation of carcinogenesis with selected GRAS nutraceuticals via Keap1‐Nrf2 signaling pathway

Contact Info

Product

Resources

About