The Therapeutic Efficacy of Ultrasound in Treatment of Autoimmune Diseases

Roseboro, J A; Norman, Amos; Machleder, Herbert I.; Paulus, Harold E.; Stern, Roger A.

doi:10.1007/978-1-4613-4307-3_122

Cited by 1 publication

(2 citation statements)

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“…The transducer was driven a t its resonant frequency in the radial mode of 65 kHz, respectively by an oscillator, a tone burst generator and an amplifier system. The total power, P, to the transducer was determined by measuring the change in temperature of the fluid as it passed through the transducer (Roseboro et al 1976). Heating above 41 ' c was avoided.…”

Section: Experimental Arrangementmentioning

confidence: 99%

“…Buckton and Baker (1972) exposed human peripheral blood cultures to 1 MHz ultrasonic intensities of 30 mW cm-*, 300 mW cm-2 and 3 W cm-2 with no increase in chromosome or chromatid aberrations over those found in controls. Further, Clarke and Hill (1970) Williams, Hughes and Nyborg (1970), Thacker (1973) and Roseboro, Norman, Machleder, Paulus and Stern (1976) have shown that ultrasonic irradiation can cause the complete lysis of some cells and irreparable damage to others.…”

Section: Introductionmentioning

confidence: 99%

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Effect of ultrasonic irradiation on Mammalian cells and chromosomes in vitro

Roseboro

Buchanan

Norman

et al. 1978

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Human peripheral blood and HeLa cells were irradiated in vitro at the ultrasonic frequency of 65 kHz. The whole blood and HeLa cell suspensions were exposed to continuous and pulsed ultrasonic power levels of 0.12, 0.16, 0.72, 1.12 and 2.24 W for a period of one minute. The method of ultrasonic irradiation was carried out with the whole blood or HeLa cell suspensions coupled directly to a cylindrical transducer while heating of the cell suspensions in excess of 41 degrees c was avoided. Irradiated and unirradiated peripheral blood lymphocyte chromosome cultures were prepared and scored for selected numerical and morphological abberrations. There was no significant difference in the frequency of chromosomal aberrations between irradiated and unirradiated cells. The fraction of cells S surviving after an exposure to an ultrasound dose of D can be represented by S = exp (-D/Do). Further, Do is shown to depend on the time after exposure at which survival is assayed.

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Section: Experimental Arrangementmentioning

confidence: 99%