The Therapeutic Effects and Mechanisms of Quercetin on Metabolic Diseases: Pharmacological Data and Clinical Evidence

Huan, Yi; Peng, Hengyang; Wu, Xinyue; Xu, Xinmei; Kuang, Tingting; Zhang, Jing; Du, Leilei; Fan, Gang

doi:10.1155/2021/6678662

Cited by 96 publications

(62 citation statements)

References 115 publications

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“…Quercetin is a plant flavonoid found in green tea, red and white onions, apples, peppers, blueberries, and dark green vegetables. Quercetin has antioxidant and anti-inflammatory properties, as well as cardioprotective, anticancer, and hepatoprotective effects [ 71 ]. In addition, quercetin has antipathogenic activities [ 72 ] which may influence immune system and resistance to pathogens.…”

Section: Quercetinmentioning

confidence: 99%

Dietary Supplementation for Attenuating Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness in Humans

Tanabe

Fujii

2021

Nutrients

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Dietary supplements are widely used as a nutritional strategy to improve and maintain performance and achieve faster recovery in sports and exercise. Exercise-induced muscle damage (EIMD) is caused by mechanical stress and subsequent inflammatory responses including reactive oxygen species and cytokine production. Therefore, dietary supplements with anti-inflammatory and antioxidant properties have the potential to prevent and reduce muscle damage and symptoms characterized by loss of muscle strength and delayed-onset muscle soreness (DOMS). However, only a few supplements are considered to be effective at present. This review focuses on the effects of dietary supplements derived from phytochemicals and listed in the International Olympic Committee consensus statement on muscle damage evaluated by blood myofiber damage markers, muscle soreness, performance, and inflammatory and oxidative stress markers. In this review, the effects of dietary supplements are also discussed in terms of study design (i.e., parallel and crossover studies), exercise model, and such subject characteristics as physical fitness level. Future perspectives and considerations for the use of dietary supplements to alleviate EIMD and DOMS are also discussed.

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Section: Quercetinmentioning

confidence: 99%

Dietary Supplementation for Attenuating Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness in Humans

Tanabe

Fujii

2021

Nutrients

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“…Quercetin (3,3 ,4 ,5,7-pentahydroxyflavone, Que) is a flavanol abundant in several foods in the MD, such as vegetables and fruits, as well as in red wine [17]. Its structure consists of two benzene rings and an oxygen-containing heterocycle, with several hydroxyl groups.…”

Section: Introductionmentioning

confidence: 99%

“…Its structure consists of two benzene rings and an oxygen-containing heterocycle, with several hydroxyl groups. This compound has a potent antioxidant effect with free radicals scavenging property, which is related to its molecular structure [17]. Several biological effects, including the improvement of IR and the reduction of obesity, have been ascribed to the intake of quercetin [17,18].…”

Section: Introductionmentioning

confidence: 99%

“…This compound has a potent antioxidant effect with free radicals scavenging property, which is related to its molecular structure [17]. Several biological effects, including the improvement of IR and the reduction of obesity, have been ascribed to the intake of quercetin [17,18]. The beneficial properties of Que have been correlated to its anti-inflammatory activity, which plays a role in protecting against diabetes, obesity, cardiovascular and neurodegenerative diseases [13,19].…”

Section: Introductionmentioning

confidence: 99%

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Quercetin Reduces Lipid Accumulation in a Cell Model of NAFLD by Inhibiting De Novo Fatty Acid Synthesis through the Acetyl-CoA Carboxylase 1/AMPK/PP2A Axis

Gnoni

Stanca

Giannotti

et al. 2022

IJMS

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Dysregulation of de novo lipogenesis (DNL) has recently gained strong attention as being one of the critical factors that contribute to the assessment of non-alcoholic fatty liver disease (NAFLD). NAFLD is often diagnosed in patients with dyslipidemias and type 2 diabetes; thus, an interesting correlation can be deduced between high hematic free fatty acids and glucose excess in the DNL dysregulation. In the present study, we report that, in a cellular model of NAFLD, the coexistence of elevated glucose and FFA conditions caused the highest cellular lipid accumulation. Deepening the molecular mechanisms of the DNL dysregulation—RT-qPCR and immunoblot analysis demonstrated increased expression of mitochondrial citrate carrier (CiC), cytosolic acetyl-CoA carboxylase 1 (ACACA), and diacylglycerol acyltransferase 2 (DGAT2) involved in fatty acids and triglycerides synthesis, respectively. XBP-1, an endoplasmic reticulum stress marker, and SREBP-1 were the transcription factors connected to the DNL activation. Quercetin (Que), a flavonoid with strong antioxidant properties, and noticeably reduced the lipid accumulation and the expression of SREBP-1 and XBP-1, as well as of their lipogenic gene targets in steatotic cells. The anti-lipogenic action of Que mainly occurs through a strong phosphorylation of ACACA, which catalyzes the committing step in the DNL pathway. The high level of ACACA phosphorylation in Que-treated cells was explained by the intervention of AMPK together with the reduction of enzymatic activity of PP2A phosphatase. Overall, our findings highlight a direct anti-lipogenic effect of Que exerted through inhibition of the DNL pathway by acting on ACACA/AMPK/PP2A axis; thus, suggesting this flavonoid as a promising molecule for the NAFLD treatment.

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“…11 The active ingredients in the above herbals include geniposide, genipin, chlorogenic acid, resveratrol, polydatin, kaempferol, quercetin, etc., which are reported to improve NAFLD. [12][13][14][15][16][17][18][19][20] Preliminary research suggests that the QSHY decoction inhibits hepatic lipid accumulation by activating AMPK in vivo and in vitro and corrects intestinal microbial disorders. 21,22 Moreover, QSHY decoction can significantly inhibit weight gain induced by a high-fat and high-sugar (HFHS) diet in mice, and this may be related to the promotion of WAT browning; however, the related mechanisms are yet to be studied.…”

Section: Introductionmentioning

confidence: 99%

QSHY Granules Promote White Adipose Tissue Browning and Correct BCAAs Metabolic Disorder in NAFLD Mice

Zhang¹,

Ni²,

Li³

et al. 2021

DMSO

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Purpose: White adipose tissue (WAT) has positive effects on peripheral metabolism parameters and liver energy metabolism. This study aimed to explain the pharmacological mechanism of Qushi Huayu (QSHY) granules in the treatment of nonalcoholic fatty liver disease (NALFD) mice based on branched-chain amino acid (BCAA) catabolism and WAT browning. Patients and Methods: Thirty C57BL/6J mice were randomly divided into a (Ctrl) control group, fed with a control diet, a NAFLD model group, fed with a high-fat and high-sugar (HFHS) diet, and a QSHY granules treatment (HFHS+QSHY) group, administered with QSHY granules. After 14 weeks of feeding, HFHS+QSHY group mice were administered QSHY granules through oral gavage for 6 weeks. The metabolic parameters were assessed, the circular and fecal BCAA content was observed, and liver and epididymal WAT (eWAT) were collected for pathological, quantitative real-time polymerase chain reaction, and Western blotting analyses. Results: Compared with the HFHS group, mice in the HFHS+QSHY group demonstrated restored liver histological changes, ameliorated hepatocyte steatosis, and alleviated inflammatory cell infiltration. Consistent with the pathological changes, QSHY granules significantly reduced the elevated levels of liver triglycerides, and serum alanine aminotransferase, and it relieved hypercholesterolemia and insulin resistance in mice with HFHS-induced NAFLD. Furthermore, it corrected BCAA metabolic disorders in serum and feces and promoted the expression of BCAA catabolic genes in the eWAT of HFHS mice. QSHY granules also increased the expression of phosphorylated AMP-activated protein kinase (AMPK) protein, up-regulating the protein expression of the AMPK/SIRT1/UCP-1 pathway in the eWAT. Conclusion: QSHY granules improved hepatic steatosis and corrected the BCAA disorder in NAFLD mice, and the related mechanisms regulated the AMPK/SIRT1/UCP-1 pathway and promoted WAT browning.

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The Therapeutic Effects and Mechanisms of Quercetin on Metabolic Diseases: Pharmacological Data and Clinical Evidence

Cited by 96 publications

References 115 publications

Dietary Supplementation for Attenuating Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness in Humans

Dietary Supplementation for Attenuating Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness in Humans

Quercetin Reduces Lipid Accumulation in a Cell Model of NAFLD by Inhibiting De Novo Fatty Acid Synthesis through the Acetyl-CoA Carboxylase 1/AMPK/PP2A Axis

QSHY Granules Promote White Adipose Tissue Browning and Correct BCAAs Metabolic Disorder in NAFLD Mice

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