The therapeutic effect of Yinhuangerchen mixture on Avian infectious laryngotracheitis

Zhang, Tie; Chen, Jian; Wang, Chunguang; Shi, Wei; Li, Dinggang

doi:10.3382/ps/pey125

Cited by 6 publications

(4 citation statements)

References 1 publication

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“…There are few reports regarding the use of herbal drugs for the treatment of ILTV. At higher concentration, Yinhuangerchen, a Chinese herbal mixture reduced the level of ILTV in tissues and also developed mucosal immunity, in birds treated with Yinhuangerchen mixture after 72 hours post-infection (Zhang et al 2018). Cheng et al (2011) found that the Huangqi Maxingshigan decoction, containing five herbal medicines (Almond, Gypsum fibrosum, Herba ephedrae, Radix astragali, Radix glycytthizae) provided an antioxidant defense in the process of anti-ILT.…”

Section: Control and Eradicationmentioning

confidence: 99%

Infectious laryngotracheitis: Etiology, epidemiology, pathobiology, and advances in diagnosis and control – a comprehensive review

Gowthaman

Kumar

Koul

et al. 2020

Veterinary Quarterly

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Infectious laryngotracheitis (ILT) is a highly contagious upper respiratory tract disease of chicken caused by a Gallid herpesvirus 1 (GaHV-1) belonging to the genus Iltovirus, and subfamily Alphaherpesvirinae within Herpesviridae family. The disease is characterized by conjunctivitis, sinusitis, oculo-nasal discharge, respiratory distress, bloody mucus, swollen orbital sinuses, high morbidity, considerable mortality and decreased egg production. It is well established in highly dense poultry producing areas of the world due to characteristic latency and carrier status of the virus. Co-infections with other respiratory pathogens and environmental factors adversely affect the respiratory system and prolong the course of the disease. Latently infected chickens are the primary source of ILT virus (ILTV) outbreaks irrespective of vaccination. Apart from conventional diagnostic methods including isolation and identification of ILTV, serological detection, advanced biotechnological tools such as PCR, quantitative real-time PCR, next generation sequencing, and others are being used in accurate diagnosis and epidemiological studies of ILTV. Vaccination is followed with the use of conventional vaccines including modified live attenuated ILTV vaccines, and advanced recombinant vector vaccines expressing different ILTV glycoproteins, but still these candidates frequently fail to reduce challenge virus shedding. Some herbal components have proved to be beneficial in reducing the severity of the clinical disease. The present review discusses ILT with respect to its current status, virus characteristics, epidemiology, transmission, pathobiology, and advances in diagnosis, vaccination and control strategies to counter this important disease of poultry.

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Section: Control and Eradicationmentioning

confidence: 99%

Infectious laryngotracheitis: Etiology, epidemiology, pathobiology, and advances in diagnosis and control – a comprehensive review

Gowthaman

Kumar

Koul

et al. 2020

Veterinary Quarterly

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“…However, at present, most chicken are vaccinated with NDV, leading to the existence of antibodies in healthy chickens, thus affecting the judgment results. The diagnostic methods of molecular biology include conventional PCR, real-time fluorescence–based quantitative PCR ( RFQ-PCR ), loop-mediated isothermal amplification, and so on ( Lin et al., 1991 , Zhang et al., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Establishment of reverse transcription recombinase–aided amplification-lateral-flow dipstick and real-time fluorescence–based reverse transcription recombinase–aided amplification methods for detection of the Newcastle disease virus in chickens

Wang

Bai

et al. 2020

Poultry Science

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Newcastle disease is an acute and highly contagious disease of poultry caused by Newcastle disease virus infection, which does great harm to the poultry industry all over the world. To diagnose the disease simply and quickly, 2 detection methods were established based on reverse transcription recombinase–aided amplification ( RT-RAA ) technology. One is reverse transcription recombinase–aided amplification-lateral flow dipstick ( RT-RAA-LFD ) that is to combine RT-RAA with lateral flow dipstick; the other is real-time fluorescence-based reverse transcription recombinase–aided amplification ( RF-RT-RAA ) that is the combination of RT-RAA and exo probe. In this study, the reaction conditions such as reaction temperature and reaction time of the 2 methods were optimized, and their specificity and sensitivity were tested. The results showed that the RT-RAA-LFD method could be used to complete reaction within 23 min, and its lowest detectable limit was 10 2 copies/μL, 10 times higher than that of the conventional PCR method (10 3 copies/μL); the RF-RT-RAA method could be used to complete reaction within 26 min, and its lowest detectable limit was 10 copies/μL, 100 times higher than that of conventional PCR method (10 3 copies/μL), and it was as sensitive as real-time fluorescence–based quantitative PCR (10 copies/μL). The 2 methods had no cross reaction to the nucleic acid of other avian pathogens and showed good specificity. A total of 86 clinical samples suspected of the Newcastle disease virus were tested by conventional PCR, real-time fluorescence–based quantitative PCR, RT-RAA-LFD, and RF-RT-RAA. Based on the commonly used conventional PCR method, the other 3 detection methods had a coincidence rate of higher than 93%. In summary, RT-RAA-LFD and RF-RT-RAA had high specificity, sensitivity, and efficiency, which were suitable for clinical and laboratory diagnosis, respectively, and provided technical support for the prevention and control of Newcastle disease.

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“…Viscera index is considered to represent the level of immune development [ 20 – 22 ]. sIgA can represent the level of mucosal immunity [ 23 , 24 ]. The interaction between flora and sIgA is significant [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Regulation Effect of a Chinese Herbal Formula on Flora and Mucosal Immune Secretory Immunoglobulin A in Rats

Liu

Zhang

Han

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Flora and mucosal immunity are considered to be the barrier, which is associated with multiple respiratory diseases, including recurrent respiratory tract infection (RRTI). Fei-Xi-Tiao-Zhi-Fang (FTF) is a traditional Chinese herbal formula used in the treatment of RRTI. However, the mechanism is little known. This study aims to identify the function of FTF in flora and mucosal immune secretory immunoglobulin A (sIgA) in the model of RRTI rats. The samples of intestine and lung were collected to detect sIgA, short chain fatty acids (SCFAS), and flora with enzyme-linked immunosorbent assay (ELISA), gas chromatography, and 16S rDNA sequencing. The body weight and viscera index were increased dynamically in RRTI rats after the administration of FTF. Furthermore, the types and proportions of aboriginal flora were significantly changed in the model group, whereas the altered flora was rescued in the FTF administration group. Desulfovibrio increased in the intestinal microflora and Ralstonia and Blautia decreased in the pulmonary microflora at the genus level, similar to that in the normal group. In addition, the expressions of sIgA in pulmonary and intestinal tissues were significantly upregulated and the level of SCFAS was increased in FTF group compared to the RRTI model group. Our study suggests that FTF can alleviate the symptoms of RRTI by increasing sIgA and SCFAS, recovering flora, and improving the immunity.

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The therapeutic effect of Yinhuangerchen mixture on Avian infectious laryngotracheitis

Cited by 6 publications

References 1 publication

Infectious laryngotracheitis: Etiology, epidemiology, pathobiology, and advances in diagnosis and control – a comprehensive review

Infectious laryngotracheitis: Etiology, epidemiology, pathobiology, and advances in diagnosis and control – a comprehensive review

Establishment of reverse transcription recombinase–aided amplification-lateral-flow dipstick and real-time fluorescence–based reverse transcription recombinase–aided amplification methods for detection of the Newcastle disease virus in chickens

Regulation Effect of a Chinese Herbal Formula on Flora and Mucosal Immune Secretory Immunoglobulin A in Rats

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