The Therapeutic Effect of Nigella sativa Seed on Indomethacin-induced Gastric Ulcer in Rats

Paseban, Maryam; Niazmand, Saeed; Soukhtanloo, Mohammad; Meibodi, Naser Tayyebi; Abbasnezhad, Abbasali; Mousavi, Seyed Mojtaba; Niazmand, Mohammad Javad

doi:10.2174/1573401315666190114152855

Cited by 6 publications

(3 citation statements)

References 45 publications

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“…The antioxidant activity plays a key role in the gastroprotective property as it increases the total hexose in gastric mucus secretion and gastric mucosa. N. sativa seeds could significantly decrease malondialdehyde protein levels, which is concurrent with the rise in mucus content, total thiol and total hexose as compared to the control group without influencing gastric acid secretion [55] .…”

Section: Antioxidant Potential Of N Sativamentioning

confidence: 86%

Efficacy of Nigella sativa in Wound Healing

Almuhayawi¹

2023

IJPS

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Almuhayawi: Role of Nigella sativa in Wound Healing Skin rupture (open wound) intensifies bacterial colonization in underlying injured tissues. It initiates as a focal infection and might develop into an invasive and systemic infection. Multi-drug resistant bacteria have emerged as a global issue with their rising infections in humans and various animal species. The development of efficient alternative therapies could minimize antibiotic usage by countering antibiotic resistance. Alternative therapies can particularly be beneficial in treating mild infections. Nigella sativa, also known as black cumin or black seeds, is a medicinal herb native to the eastern Mediterranean, Northern Africa, Southwest Asia and the Indian subcontinent. The efficacy of Nigella sativa against Gram-positive and Gram-negative bacteria has been demonstrated in multiple studies. Nigella sativa is known to possess antioxidative, anti-inflammatory, wound healing and antibacterial properties. The antiseptic and antibacterial capability seems to facilitate the speedy recovery of wounds. This review summarizes recent studies related to Nigella sativa wound healing properties.

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Section: Antioxidant Potential Of N Sativamentioning

confidence: 86%

Efficacy of Nigella sativa in Wound Healing

Almuhayawi¹

2023

IJPS

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“…In light of this, several reports revealed that black seed oil (BSO) has a protective and healing effect on gastric ulcers [14,15]. Along with this, various studies showed that the administration of thymoquinone (TMQ), the major constituent in BSO, reduces peptic ulcers produced by NSAIDs and other agents like ethanol [16][17][18]. In detail, Kanter et al studied the impact of BSO and TMQ on gastric ulcers in rats.…”

Section: Introductionmentioning

confidence: 99%

Development of a Multifunctional Oral Dosage Form via Integration of Solid Dispersion Technology with a Black Seed Oil-Based Self-Nanoemulsifying Drug Delivery System

Sherif,

Shahba

2023

Biomedicines

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Lansoprazole (LZP) is used to treat acid-related gastrointestinal disorders; however, its low aqueous solubility limits its oral absorption. Black seed oil (BSO) has gastroprotective effects, making it a promising addition to gastric treatment regimens. The present study aims to develop a stable multifunctional formulation integrating solid dispersion (SD) technology with a bioactive self-nanoemulsifying drug delivery system (SNEDDS) based on BSO to synergistically enhance LZP delivery and therapeutic effects. The LZP-loaded SNEDDS was prepared using BSO, Transcutol P, and Kolliphor EL. SDs were produced by microwave irradiation and lyophilization using different polymers. The formulations were characterized by particle apparent hydrodynamic radius analysis, zeta potential, SEM, DSC, PXRD, and in vitro dissolution testing. Their chemical and physical stability under accelerated conditions was also examined. Physicochemical characterization revealed that the dispersed systems were in the nanosize range (<500 nm). DSC and PXRD studies revealed that lyophilization more potently disrupted LZP crystallinity versus microwave heating. The SNEDDS effectively solubilized LZP but degraded completely within 1 day. Lyophilized SDs with Pluronic F-127 demonstrated the highest LZP dissolution efficiency (3.5-fold vs. drug) and maintained chemical stability (>97%) for 1 month. SDs combined with the SNEDDS had variable effects suggesting that the synergistic benefits were dependent on the formulation and preparation method. Lyophilized LZP-Pluronic F127 SD enabled effective and stable LZP delivery alongside the bioactive effects of the BSO-based SNEDDS. This multifunctional system is a promising candidate with the potential for optimized gastrointestinal delivery of LZP and bioactive components.

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“…Gastrointestinal and liver disease are common in patients with diabetes mellitus 2 . Evolving evidence proposes that oxidative stress has an key role in the diabetes complications pathogenesis including gastrointestinal and liver disease 3 .…”

Section: Introductionmentioning

confidence: 99%

Comparison Effect of Different Combinations of Metformin, Atorvastatin, Captopril and Aspirin on Oxidative Stress Markers of Gastric and Liver Tissues of Diabetic Rats

Niazmand,

Mohebbati,

Mirzaee

et al. 2023

Bulletin of Pharmaceutical Sciences Assiut University

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Some recent studies have been suggested high -dose aspirin consumption in diabetic patient because of its modifying effect on metabolism of glucose and lipid. In other side many researches showed aspirin induced gastrointestinal damage. Investigation of the effect of highdose aspirin consumption in combinations with metformin, captopril and atorvastatin on oxidative stress markers in the stomach and liver tissues of diabetic rats. Rats divided into eleven groups: control (Cont), diabetic (D), and 9 treated groups with various combination of metformin (M), atorvastatin (AT), captopril (C), and aspirin (ASA). Animals were treated orally by M, C, AT and ASA daily for 6 weeks. Finally, oxidative markers were evaluated in stomach and liver tissues. The Malondialdehyde (MDA) level significantly boosted while total thiol content remarkably decreased in the diabetic group than the control. Administration of the different combinations of C, M, AT and ASA could significantly attenuate above parameters. Combination of the metformin, aspirin, atorvastatin and captopril has more marked effects on oxidative stress reduction in the stomach and liver tissues of diabetic rats and could ameliorated probably oxidative stress induced by aspirin.

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The Therapeutic Effect of Nigella sativa Seed on Indomethacin-induced Gastric Ulcer in Rats

Cited by 6 publications

References 45 publications

Efficacy of Nigella sativa in Wound Healing

Efficacy of Nigella sativa in Wound Healing

Development of a Multifunctional Oral Dosage Form via Integration of Solid Dispersion Technology with a Black Seed Oil-Based Self-Nanoemulsifying Drug Delivery System

Comparison Effect of Different Combinations of Metformin, Atorvastatin, Captopril and Aspirin on Oxidative Stress Markers of Gastric and Liver Tissues of Diabetic Rats

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