Comparison Effect of Different Combinations of Metformin, Atorvastatin, Captopril and Aspirin on Oxidative Stress Markers of Gastric and Liver Tissues of Diabetic Rats

Abstract

Some recent studies have been suggested high -dose aspirin consumption in diabetic patient because of its modifying effect on metabolism of glucose and lipid. In other side many researches showed aspirin induced gastrointestinal damage. Investigation of the effect of highdose aspirin consumption in combinations with metformin, captopril and atorvastatin on oxidative stress markers in the stomach and liver tissues of diabetic rats. Rats divided into eleven groups: control (Cont), diabetic (D), and 9 treated groups with various combination of metformin (M), atorvastatin (AT), captopril (C), and aspirin (ASA). Animals were treated orally by M, C, AT and ASA daily for 6 weeks. Finally, oxidative markers were evaluated in stomach and liver tissues. The Malondialdehyde (MDA) level significantly boosted while total thiol content remarkably decreased in the diabetic group than the control. Administration of the different combinations of C, M, AT and ASA could significantly attenuate above parameters. Combination of the metformin, aspirin, atorvastatin and captopril has more marked effects on oxidative stress reduction in the stomach and liver tissues of diabetic rats and could ameliorated probably oxidative stress induced by aspirin.