The therapeutic contribution of nanomedicine to treat neurodegenerative diseases via neural stem cell differentiation

Carradori, Dario; Eyer, Joël; Saulnier, Patrick; Préat, Véronique; Rieux, Anne des

doi:10.1016/j.biomaterials.2017.01.032

Cited by 54 publications

(27 citation statements)

References 170 publications

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“…The prominent features of cationic lipids, such as DOTAP, DODAP, DOTMA, and DC-cholesterol, which have been used for gene therapy, include three major domains: hydrophobic tails, linking groups, and cationic cap groups 69 , 72 . The main shortcomings of cationic lipids are their unsatisfactory pharmacokinetic biodistribution due to nonspecific binding and rapid clearance, and their cytotoxicity 69 , 73 . To overcome these drawbacks, optimized cationic lipids with appropriate p K a values have been developed 68 , 70 .…”

Section: Vectors: Viral and Non-viral Based Gene Therapymentioning

confidence: 99%

Gene therapy for neurodegenerative disorders: advances, insights and prospects

Chen

2020

Acta Pharmaceutica Sinica B

113

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Gene therapy is rapidly emerging as a powerful therapeutic strategy for a wide range of neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). Some early clinical trials have failed to achieve satisfactory therapeutic effects. Efforts to enhance effectiveness are now concentrating on three major fields: identification of new vectors, novel therapeutic targets, and reliable of delivery routes for transgenes. These approaches are being assessed closely in preclinical and clinical trials, which may ultimately provide powerful treatments for patients. Here, we discuss advances and challenges of gene therapy for neurodegenerative disorders, highlighting promising technologies, targets, and future prospects.

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Section: Vectors: Viral and Non-viral Based Gene Therapymentioning

confidence: 99%

Gene therapy for neurodegenerative disorders: advances, insights and prospects

Chen

2020

Acta Pharmaceutica Sinica B

113

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“…Indeed, the complexity of the neural tissue precludes the potential of many therapeutic approaches based on stem cells. The most important factor is the lack of correlation between the in vitro and in vivo behavior of stem cells, as the microenvironment is essential for their differentiation [48]. For this reason, an important challenge to overcome for the therapeutic use of stem cells in vivo is represented by the understanding of the surrounding chemical and physical signals as well as cell-cell interactions [49].…”

Section: Current Treatmentsmentioning

confidence: 99%

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Bordoni

Scarian

Rey

et al. 2020

IJMS

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Neurodegenerative disorders (i.e., Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and spinal cord injury) represent a great problem worldwide and are becoming prevalent because of the increasing average age of the population. Despite many studies having focused on their etiopathology, the exact cause of these diseases is still unknown and until now, there are only symptomatic treatments. Biomaterials have become important not only for the study of disease pathogenesis, but also for their application in regenerative medicine. The great advantages provided by biomaterials are their ability to mimic the environment of the extracellular matrix and to allow the growth of different types of cells. Biomaterials can be used as supporting material for cell proliferation to be transplanted and as vectors to deliver many active molecules for the treatments of neurodegenerative disorders. In this review, we aim to report the potentiality of biomaterials (i.e., hydrogels, nanoparticles, self-assembling peptides, nanofibers and carbon-based nanomaterials) by analyzing their use in the regeneration of neural and glial cells their role in axon outgrowth. Although further studies are needed for their use in humans, the promising results obtained by several groups leads us to suppose that biomaterials represent a potential therapeutic approach for the treatments of neurodegenerative disorders.

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“…The rapid development of nanotechnology provides a variety of nanomaterials, especially metal nanoparticles, carbon nanomaterials, semiconductor nanomaterials, polymeric nanoparticles and DNA nanostructures, which are promising in regulating stem cell behavior and tissue regeneration [ 135 , 136 ]. Nanomaterials can potently modulate the drug-loaded release or microenvironments involved in stem cell differentiation, and enhance their efficiency and safety [ 123 ].…”

Section: Discussionmentioning

confidence: 99%

Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms

Wei

2017

J Nanobiotechnol

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Stem cells are unspecialized cells that have the potential for self-renewal and differentiation into more specialized cell types. The chemical and physical properties of surrounding microenvironment contribute to the growth and differentiation of stem cells and consequently play crucial roles in the regulation of stem cells’ fate. Nanomaterials hold great promise in biological and biomedical fields owing to their unique properties, such as controllable particle size, facile synthesis, large surface-to-volume ratio, tunable surface chemistry, and biocompatibility. Over the recent years, accumulating evidence has shown that nanomaterials can facilitate stem cell proliferation and differentiation, and great effort is undertaken to explore their possible modulating manners and mechanisms on stem cell differentiation. In present review, we summarize recent progress in the regulating potential of various nanomaterials on stem cell differentiation and discuss the possible cell uptake, biological interaction and underlying mechanisms.

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The therapeutic contribution of nanomedicine to treat neurodegenerative diseases via neural stem cell differentiation

Cited by 54 publications

References 170 publications

Gene therapy for neurodegenerative disorders: advances, insights and prospects

Gene therapy for neurodegenerative disorders: advances, insights and prospects

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms

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