The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea

Wang, Lian; Wang, Yujia; Hao, Dan; Wen, Xiang; Du, Dan; He, Gu; Jiang, Xian

doi:10.3389/fmed.2019.00324

Cited by 31 publications

(31 citation statements)

References 64 publications

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“…Nakamura et al, on the basis of histopathological tests of the skin of patients with plaque psoriasis and accompanying pruritus, found MCs present and their granularity [86,87] near unmyelinated nerve fibers, which was not observed in patients without pruritus. Moreover, a large number of MCs in the stratum papillare of the dermis was also observed in these patients [88]. This offers some basis to look for mast-cell-targeted treatment in order to reduce the inflammation and pruritus in psoriasis patients.…”

Section: Interaction Between Mast Cells and Different Immunological Molecules In Psoriasismentioning

confidence: 73%

Psychological Stress, Mast Cells, and Psoriasis—Is There Any Relationship?

Woźniak

Owczarczyk‐Saczonek

Placek

2021

IJMS

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Psoriasis vulgaris is a common inflammatory skin disease with still unknown pathogenesis. In recent years, genetic and environmental factors have been mentioned as the main causes. Among environmental factors, many researchers are trying to investigate the role of mental health and its importance in the development of many diseases. In the pathophysiology of psoriasis, the role of the interaction between the nervous, endocrine, and immune systems are often emphasized. So far, no one has clearly indicated where the pathological process begins. One of the hypotheses is that chronic stress influences the formation of hormonal changes (lowering the systemic cortisol level), which favors the processes of autoimmunity. In inflammatory skin conditions, mast cells (MCs) are localized close to blood vessels and peripheral nerves, where they probably play an important role in the response to environmental stimuli and emotional stress. They are usually connected with a fast immune response, not only in allergies but also a protective response to microbial antigens. Among many cells of the immune system, MCs have receptors for the hormones of the hypothalamic–pituitary–adrenal (HPA) axis on their surface. In this review, we will try to take a closer look at the role of MCs in the pathophysiology of psoriasis. This knowledge may give the opportunity to search for therapeutic solutions.

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Section: Interaction Between Mast Cells and Different Immunological Molecules In Psoriasismentioning

confidence: 73%

Psychological Stress, Mast Cells, and Psoriasis—Is There Any Relationship?

Woźniak

Owczarczyk‐Saczonek

Placek

2021

IJMS

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“…Recent data suggest that MCs play a significant role in the inflammatory pathogenesis of rosacea leading to cutaneous erythema, telangiectasias, and the formation of papules and pustules [47]. In this review, we analyzed existing and emerging MC stabilizing agents in the treatment of rosacea and explored the mechanistic roles for these agents in controlling MCrelated inflammation seen in rosacea.…”

Section: Discussionmentioning

confidence: 99%

Mast Cell Stabilizers in the Treatment of Rosacea: A Review of Existing and Emerging Therapies

Marchitto

Chien

2021

Dermatol Ther (Heidelb)

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Rosacea is a chronic inflammatory skin disease characterized by centrofacial erythema, papules, pustules, and telangiectasias. The onset of rosacea typically occurs after 30 years of age. It is estimated that approximately 2-5% of adults worldwide are affected. While the exact etiology of rosacea remains unknown, its pathogenesis is thought to be multifactorial with both environmental and genetic factors implicated. Ultraviolet radiation, heat, steam, ingested agents, including spicy foods and alcohol, host vasculature, dermal matrix degeneration, genetic susceptibility, and microbial organisms, including Demodex mites and Heliobacter pylori, have been implicated in the development of rosacea. Recently, mast cells (MCs) have emerged as key players in the pathogenesis of rosacea through the release of pro-inflammatory cytokines, chemokines, proteases, and antimicrobial peptides leading to cutaneous vasodilation, angiogenesis, and tissue fibrosis. Several existing and emerging topical, oral, and injectable therapeutics have been associated with improvement of rosacea symptoms based on their ability to stabilize and downregulate activated MCs. Herein, we review the data implicating MCs in the pathogenesis of rosacea and discuss interventions that may stabilize this pathway.

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“…Mast cells also participate in the appearance of rosacea by increasing inflammation, angiogenesis, and fibrosis [49]. More recently, rosacea and other skin diseases such as psoriasis and atopic dermatitis have been linked to intestinal dysbiosis, although the role of the association of Helicobacter pylori infection or SIBO-small intestinal bacterial overgrowth is still debated [50]. However, the cascade of inflammatory reactions and triggers is much wider.…”

Section: Discussionmentioning

confidence: 99%

The use of NDYAG laser combined with pulsed light in the treatment of rosacea

Ardeleanu¹,

Moroianu²,

Constantin³

et al. 2020

JMMS

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Rosacea is a chronic inflammatory skin disease with a complex pathogenesis that mainly affects the central part of the face, with a global incidence of 5.46%. The present study was performed on a group of 68 patients with rosacea 1 and 2 subtypes, patients between 34-63 years old. The treatments were performed using a Cutera Xeo laser, using 2 types of probes: NdYag 1064nm for telangiectasias and LimeLight 520-1100nm for diffuse facial erythema, papules, and pustules, having an 10x30mm window. For patients with diffuse facial erythema, etc., the optimal number of sessions was between 3 and 6 with or without anesthetic cream, using energies between 14-19J / cm. The average recovery time was 5 days. Registered effects included bruises, pustules, burning sensation, transient stinging, and hypopigmentation. For patients with telangiectasia, the optimal number of sessions was two, performed at an average interval of once per month/ monthly.

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The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea

Cited by 31 publications

References 64 publications

Psychological Stress, Mast Cells, and Psoriasis—Is There Any Relationship?

Psychological Stress, Mast Cells, and Psoriasis—Is There Any Relationship?

Mast Cell Stabilizers in the Treatment of Rosacea: A Review of Existing and Emerging Therapies

The use of NDYAG laser combined with pulsed light in the treatment of rosacea

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