The theory and practice of industrial pharmacy. Second Ed. L. Lachman, H. A. Lieberman, and J. L. Kanig. Lea & Febiger, 600 Washington Square, Philadelphia, PA 19106, 1976. 787pp. 18.5 × 26.5cm. Price $38.50

Dissolution Rate Equations in CoIumn-Confined Dissolution

“…The principal structural feature characteristic of the liquid crystalline state is the parallel arrangement of the component molecules, with rotation primarily being permitted only about the long axis. Because of increasing interest in the mesomorphic states, the characteristic features and properties associated with these systems have been extensively reviewed (4,5). However, studies of reaction kinetics in such novel solvents are relatively few (6-10).…”

“…The column was loaded with glass spheres at E to a depth of 1 cm, then with 1 cm of glass wool (at F), and then with 40 cm (-33 g) of oxalic acid dihydrate crystals of a given mesh sieve fraction. Glass wool (1 cm) and glass beads (8 cm) were then added at points G and H. The purpose of the glass beads at E is to rectify the turbulence that occurs at the pipe widening beyond the stopcock (5). The purpose of the glass beads at H is to weight down the column so that it does not move upward during experiments performed a t high liquid velocity.…”

Release Profile of Branded Atorvastatin Calcium Tablet Relative to Commercially Available Counterpart Generics

“…For any tablet dosage form, unintended chemical breakdown or interaction between constituents may alter the physicochemical properties, thereby potentially disturbing bioavailability of the tablet formulation (12,24). Thus, evaluating critical quality parameters such as tablet mechanical strength and consistency for weight and content of the active pharmaceutical ingredient (API) is important (22).…”