The thalamic midline nucleus reuniens: potential relevance for schizophrenia and epilepsy

Weel, M.J. Dolleman-van der

doi:10.1016/j.neubiorev.2020.09.033

Cited by 19 publications

(7 citation statements)

References 236 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, as mentioned above, the increased activity in the ilPFC underlies the hypodopaminergic state in rats subjected to CMS ( Moreines et al, 2017b ). The ilPFC excitability observed in animal models of affective dysregulation may disrupt the vHip activity indirectly via the reuniens thalamic nucleus ( Dolleman-van der Weel and Witter, 2020 ), which also has been shown to regulate amotivational behaviors and dopaminergic activity ( Zimmerman and Grace, 2016 ; Kafetzopoulos et al, 2018 ). Rats expressing helplessness have a disruption of long-term potentiation (LTP) in vHip-NAc plasticity ( Belujon and Grace, 2014 ).…”

Section: Integrating Disease Risk Factors For the Study Of Schizophre...mentioning

confidence: 99%

Using animal models for the studies of schizophrenia and depression: The value of translational models for treatment and prevention

Uliana

Zhu

Gomes

et al. 2022

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Animal models of psychiatric disorders have been highly effective in advancing the field, identifying circuits related to pathophysiology, and identifying novel therapeutic targets. In this review, we show how animal models, particularly those based on development, have provided essential information regarding circuits involved in disorders, disease progression, and novel targets for intervention and potentially prevention. Nonetheless, in recent years there has been a pushback, largely driven by the US National Institute of Mental Health (NIMH), to shift away from animal models and instead focus on circuits in normal subjects. This has been driven primarily from a lack of discovery of new effective therapeutic targets, and the failure of targets based on preclinical research to show efficacy. We discuss why animal models of complex disorders, when strongly cross-validated by clinical research, are essential to understand disease etiology as well as pathophysiology, and direct new drug discovery. Issues related to shortcomings in clinical trial design that confound translation from animal models as well as the failure to take patient pharmacological history into account are proposed to be a source of the failure of what are likely effective compounds from showing promise in clinical trials.

show abstract

Section: Integrating Disease Risk Factors For the Study Of Schizophre...mentioning

confidence: 99%

Using animal models for the studies of schizophrenia and depression: The value of translational models for treatment and prevention

Uliana

Zhu

Gomes

et al. 2022

Front. Behav. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Epilepsy is thought to be a abnormal network disease, and focal seizures preferentially engage specific localised networks [26,27]. The cortico-thalamo-hippocampal is a crucial circuit of the complex brain networks, which has a close relationship with the occurrence and progression of epilepsy [28][29][30]. As a functional hub for information flow of the cortico-thalamo-hippocampal circuit, the TRN has attracted much attention.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory effect of kainic acid on HMGB1/TLR4 pathway in a thalamic reticular nucleus slice seizure model in rats

Zhang²,

Liu

et al. 2022

Preprint

View full text Add to dashboard Cite

Objective: To explore the relationship between pro-inflammatory factor high-mobility group box 1 (HMGB1) and glutamatergic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the development of epilepsy. Methods: Thalamic reticular nucleus (TRN) slice was treated with kainic acid (KA) to simulate seizure. Seizure-like spikes and spontaneous inhibitory postsynaptic currents (sIPSCs) were recorded within TRN slices using whole-cell patch clamp techniques. The translocation of HMGB1 were detected by Immunofluorescence. HMGB1/TLR4 signaling pathway and its downstream inflammatory factors (IL-1β and NF-κB) were detected by RT-PCR, Western blot and ELISA. Results: KA-evoked seizure-like spikes were observed in the TRN slices and blocked by perampanel. sIPSCs in the TRN were enhanced by KA and blocked by perampanel. The translocation of HMGB1 in TRN were promoted by KA and inhibited by perampanel. The expression of HMGB1/TLR4 signaling pathway were promoted by KA and suppressed by perampanel. Conclusion: The AMPA receptor and HMGB1/TLR4 signaling pathway interaction jointly contribute to the development of epilepsy.

show abstract

“…In this context, spatial working memory relies on theta and gamma oscillation coherence between PFC and HPC (Kupferschmidt & Gordon, 2018). Deficits in this cognitive aspect or anatomical defects in medial thalamic regions (Ceyhan et al, 2008; Nopoulos et al, 2001; Takahashi et al, 2008) all have been associated with schizophrenia (Dolleman‐van der Weel & Witter, 2020) or dementias.…”

Section: Discussionmentioning

confidence: 99%

Coupling between the prelimbic cortex, nucleus reuniens, and hippocampus during NREM sleep remains stable under cognitive and homeostatic demands

Bozic

Rusterholz

Mikutta

et al. 2022

Eur J of Neuroscience

View full text Add to dashboard Cite

The interplay between the medial prefrontal cortex and hippocampus during non-rapid eye movement (NREM) sleep contributes to the consolidation of contextual memories. To assess the role of the thalamic nucleus reuniens (Nre) in this interaction, we investigated the coupling of neuro-oscillatory activities among prelimbic cortex, Nre, and hippocampus across sleep states and their role in the consolidation of contextual memories using multi-site electrophysiological recordings and optogenetic manipulations. We showed that ripples are time-locked to the Up state of cortical slow waves, the transition from UP to DOWN state in thalamic slow waves, the troughs of cortical spindles, and the peaks of thalamic spindles during spontaneous sleep, rebound sleep and sleep following a fear conditioning task. In addition, spiking activity in Nre increased before hippocampal ripples, and the phaselocking of hippocampal ripples and thalamic spindles during NREM sleep was stronger after acquisition of a fear memory. We showed that optogenetic inhibition of Nre neurons reduced phase-locking of ripples to cortical slow waves in the ventral hippocampus whilst their activation altered the preferred phase

show abstract

The thalamic midline nucleus reuniens: potential relevance for schizophrenia and epilepsy

Cited by 19 publications

References 236 publications

Using animal models for the studies of schizophrenia and depression: The value of translational models for treatment and prevention

Using animal models for the studies of schizophrenia and depression: The value of translational models for treatment and prevention

Immunomodulatory effect of kainic acid on HMGB1/TLR4 pathway in a thalamic reticular nucleus slice seizure model in rats

Coupling between the prelimbic cortex, nucleus reuniens, and hippocampus during NREM sleep remains stable under cognitive and homeostatic demands

Contact Info

Product

Resources

About