The Tetracyclines

Ory, Edwin M.

doi:10.1016/s0025-7125(16)32585-8

Cited by 13 publications

(2 citation statements)

References 41 publications

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“…In current clinical practice, tetracycline use is often limited due to preferential selection of newer tetracycline derivatives such as doxycycline. Although there are various reasons for this, both administration (four times daily for tetracycline versus twice daily for doxycycline) and better tolerability with doxycycline have been well described [9]. Chlortetracycline, the first tetracycline antibiotic identified, is no longer utilized in humans, rather, it still holds utility as a veterinary antibiotic [9].…”

Section: Resultsmentioning

confidence: 99%

“…Although there are various reasons for this, both administration (four times daily for tetracycline versus twice daily for doxycycline) and better tolerability with doxycycline have been well described [9]. Chlortetracycline, the first tetracycline antibiotic identified, is no longer utilized in humans, rather, it still holds utility as a veterinary antibiotic [9]. Due to its lack of current use, it was excluded from this review, despite its shared characteristics of both allergic reaction and cross-reactivity with other tetracyclines.…”

Section: Resultsmentioning

confidence: 99%

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Tetracycline Allergy

Hamilton

Guarascio

2019

Pharmacy

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Despite the widespread use of tetracycline antibiotics since the late 1940s, tetracycline hypersensitivity reactions have rarely been described in the literature. A comprehensive PubMed search was performed, including allergic and serious adverse reactions attributed to the tetracyclines class of antibiotics. Of the evaluated tetracycline analogs, minocycline was attributed to the greatest overall number and severity of serious adverse events reported in the literature, with notable reactions primarily reported as respiratory and dermatologic in nature. Reactions to tetracycline have also been well described in the literature, and although dermatologic reactions are typically less severe in comparison with minocycline and doxycycline, various reports of anaphylactic reactions exist. Although doxycycline has been noted to have had the fewest reports of severe allergic reactions, rare descriptions of life-threatening reactions are still reported in the literature. Allergic reactions regarding tetracyclines are rare; however, adverse reaction type, severity, and frequency among different tetracycline analogs is somewhat variable. A consideration of hypersensitivity and adverse reaction incidence should be performed prior to the selection of individual tetracycline entities.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%