Tetracycline Allergy

Hamilton, Leslie A.; Guarascio, Anthony J.

doi:10.3390/pharmacy7030104

Cited by 22 publications

(10 citation statements)

References 76 publications

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“…The most common reported reaction due to tetracycline administration is a fixed drug reaction. 27 Overall, IgE-mediated immediate-type anaphylactic hypersensitivity reactions due to tetracycline use are rare, typically nonfatal when an adequate intervention is performed. When reported, most anaphylactic reactions noted by case reports have occurred within 10-45 minutes following oral or intravenous administration of tetracycline, while one case of anaphylaxis following intramuscular administration occurred rapidly in less than 20 seconds.…”

Section: Case Reportmentioning

confidence: 99%

Anaphylactic reaction: lesson learned from three cases

Datu

Katinda

Suprayogi³

2022

Intisari Sains Medis

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Background: An anaphylactic reaction is an emergency that can be life-threatening if not recognized immediately. Signs and symptoms that appear vary from mild to severe. After knowing that it is an anaphylactic reaction, it needs immediate action and special attention, especially from general practitioners who work in the emergency unit. Case presentation: In this scientific publication, three cases will be presented, all of which were found in the emergency room at Cikarang Medika Hospital, Bekasi. These cases of anaphylaxis vary in the onset of signs and symptoms, clinical manifestation, allergen, degree of severity, and therapeutic response. However, in these three cases, the initial management, which was an emergency, was the same for each patient, and all cases occurred at home; thus, education on anaphylaxis in the general community is vital, especially for the patients and their families. Conclusion: As a physician who works in the emergency room is essential to know how to quickly recognize the signs and symptoms of an anaphylactic reaction and carry out treatment as soon as possible so that patients can be helped. The first line treatment is Epinephrine and other treatment may follow after the first line has been given. It is essential that the public needs to know about the occurrence, the cause or trigger, and first aid (what they should do in the event of an anaphylactic reaction).

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Section: Case Reportmentioning

confidence: 99%

Anaphylactic reaction: lesson learned from three cases

Datu

Katinda

Suprayogi³

2022

Intisari Sains Medis

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“…Doxycycline may have the best overall safety profile regarding the potential for allergic reaction compared to minocycline and tetracycline [108].…”

Section: Tetraciclinesmentioning

confidence: 99%

Spanish Society of Allergology and Clinical Immunology (SEAIC) Vision of Drug Provocation Tests

Audicana

Ortega

Lobera

et al. 2021

J Investig Allergol Clin Immunol

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The controlled drug exposure test (DPT) is currently considered the gold standard for the diagnosis of drug allergy. Drug-induced adverse reactions (ADRs) are a growing reason for consultation in both primary and specialized care. Allergology consultations in Spain are the ones that usually study these ADRs and rule out immunological mechanisms involved in up to 90% of the cases consulted. An adequate approach to these cases has an obvious impact on the costs and efficacy of the treatments required by other specialists, so that if we did not use DPTs, patients would require more expensive, more toxic and less effective treatments in most of the cases. In recent years, a large number of new drugs have been developed and this document is intended to be a practical guide in the management of PDT with the vision of the Spanish Allergology Society. Diagnostic work begins with a detailed history of the patient. Skin tests are only useful for some medications, and in most cases the diagnosis can only be confirmed by DPT. Although there is usually cross-reactivity, DPTs can confirm the diagnosis and also help to find a tolerable alternative drug. The individual management of patients in a programmed way, taking into account both the type of drug to be studied and the patient's comorbidities, usually allows a solution to be found for the majority of patients.

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“…Oral minocycline, doxycycline, or tetracycline showed to decrease the severity of skin rash induced by EGFRi, [61][62][63][64][65][66] however, doxycycline presents a better safety profile regarding allergic potential. 67 With respect to pediatric population, doxycycline and minocycline can be prescribed to children older than eight years old and amoxicillin to children younger than eight years old. 68 Erythromycin (macrolide) is not an appropriate first-line choice as oral antibiotics unless the tetracyclines are contraindicated.…”

Section: Treatmentmentioning

confidence: 99%

Management of skin adverse reactions in oncology

Silva

Gomes

Lobo

et al. 2020

J Oncol Pharm Pract

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Chemo and targeted anticancer therapies present significant skin adverse reactions, which impair the patients’ quality of life. Cutaneous toxicities lead to poor treatment adherence, drug cessation, and psychosocial distress. This review aims to summarize the current knowledge concerning the prevention and management of skin toxicity arising from these therapies. A systematic literature search on online databases was conducted. The categorization of the main preventive and treatment measures was performed according to the level of evidence. Management of skin adverse reactions of oncology treatments is very heterogeneous, which can be explained by the lack of sound evidence-based treatments. The most studied adverse effects are papulopustular eruption, xerosis, and hand–foot syndrome. Prevention of xerosis stands out as the strategy most supported by level II studies. With respect to treatment, the use of antibiotics in papulopustular eruption resulting from anti-epidermal growth factor receptor agents is the most evidence-based approach. In general, the number of studies published in the literature classified with a level II of evidence (52%) is similar to the ones classified as level IV (33%), making clear the need of more randomized controlled trials regarding the effectiveness of preventive and treatment measures of skin adverse reactions of chemo and targeted anticancer therapies.

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Tetracycline Allergy

Cited by 22 publications

References 76 publications

Anaphylactic reaction: lesson learned from three cases

Anaphylactic reaction: lesson learned from three cases

Spanish Society of Allergology and Clinical Immunology (SEAIC) Vision of Drug Provocation Tests

Management of skin adverse reactions in oncology

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