The temporal shift of peri-implant microbiota during the biofilm formation and maturation in a canine model

Jiang, Qiming; Yi, Yu; Xu, Ruogu; Zhang, Zhengchuan; Liang, Chaoan; Sun, Hong; Deng, Feilong; Yu, Xiaolin

doi:10.1016/j.micpath.2021.105100

Cited by 9 publications

(6 citation statements)

References 59 publications

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“…Second, the in vivo dynamic changes between F. nucleatum and other microorganisms during the maturation of peri-implant biofilms should be considered to illustrate the biofilm formation characteristics of F. nucleatum . Jiang et al (2021) demonstrated the important role of F. nucleatum in biofilm formation by investigating the in vivo microbial shift using a canine model. However, the construction of animal models of peri-implant diseases does not seem to be unified at present because in the actual process of use, the implant has an upper repair structure, which cannot be achieved with animal models, thus lacking considerations such as mechanical factors.…”

Section: Discussionmentioning

confidence: 99%

Fusobacterium nucleatum: The Opportunistic Pathogen of Periodontal and Peri-Implant Diseases

Chen

Shi

et al. 2022

Front. Microbiol.

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Peri-implant diseases are considered to be a chronic destructive inflammatory destruction/damage occurring in soft and hard peri-implant tissues during the patient’s perennial use after implant restoration and have attracted much attention because of their high incidence. Although most studies seem to suggest that the pathogenesis of peri-implant diseases is similar to that of periodontal diseases and that both begin with microbial infection, the specific mechanism of peri-implant diseases remains unclear. As an oral opportunistic pathogen, Fusobacterium nucleatum (F. nucleatum) has been demonstrated to be vital for the occurrence and development of many oral infectious diseases, especially periodontal diseases. More notably, the latest relevant studies suggest that F. nucleatum may contribute to the occurrence and development of peri-implant diseases. Considering the close connection between peri-implant diseases and periodontal diseases, a summary of the role of Fusobacterium nucleatum in periodontal diseases may provide more research directions and ideas for the peri-implantation mechanism. In this review, we summarize the effects of F. nucleatum on periodontal diseases by biofilm formation, host infection, and host response, and then we establish the relationship between periodontal and peri-implant diseases. Based on the above aspects, we discuss the importance and potential value of F. nucleatum in peri-implant diseases.

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Section: Discussionmentioning

confidence: 99%

Fusobacterium nucleatum: The Opportunistic Pathogen of Periodontal and Peri-Implant Diseases

Chen

Shi

et al. 2022

Front. Microbiol.

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“…Once collected, dental plaque and saliva were separately conserved into dedicated sterile tubes containing 1 ml and 3 ml of phosphate buffered saline, respectively, kept on ice and shipped to the laboratory under frozen conditions where they were preserved at −20°C until they were processed. Specifically, since different taxonomic compositions characterize the various stages of dental plaque development, to be comparable, only mature dental plaque samples were collected (Holcombe et al 2014 , Jiang et al 2021 ). In detail, since early dental plaque turns into mature biofilms within 15/20 days, to collect only mature dental plaque, the latter were collected from dogs that had not undergone a veterinary dental hygiene procedure for at least 2 months (Herrmann et al 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Species-level characterization of saliva and dental plaque microbiota reveals putative bacterial and functional biomarkers of periodontal diseases in dogs

Alessandri,

Fontana,

Mancabelli

et al. 2024

FEMS Microbiology Ecology

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Periodontal diseases are among the most common bacterial-related pathologies affecting the oral cavity of dogs. Nevertheless, the canine oral ecosystem and its correlations with oral disease development are still far from being fully characterized. In this study, the species-level taxonomic composition of saliva and dental plaque microbiota of 30 healthy dogs was investigated through a shallow shotgun metagenomics approach. The obtained data allowed not only to define the most abundant and prevalent bacterial species of the oral microbiota in healthy dogs, including members of the genera Corynebacterium and Porphyromonas, but also to identify the presence of distinct compositional motifs in the two oral micro-niches as well as taxonomical differences between dental plaques collected from anterior and posterior teeth. Subsequently, the salivary and dental plaque microbiota of 18 dogs affected by chronic gingival inflammation and 18 dogs with periodontitis were compared to those obtained from the healthy dogs. This analysis allowed the identification of bacterial and metabolic biomarkers correlated with a specific clinical status, including members of the genera Porphyromonas and Fusobacterium as microbial biomarkers of a healthy and diseased oral status, respectively, and genes predicted to encode for metabolites with anti-inflammatory properties as metabolic biomarkers of a healthy status.

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“…and Porphyromonas spp. is observed [122]. Inflammation around a dental implant is considered one of the most difficult biological complications in dentistry because, if left untreated, it can progress and cause complete loss of implants.…”

Section: The Role Of Oral Microbiota and The Immune System In The Cou...mentioning

confidence: 99%

How Can Imbalance in Oral Microbiota and Immune Response Lead to Dental Implant Problems?

Rahnama-Hezavah,

Mertowska,

Mertowski

et al. 2023

IJMS

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Dental implantology is one of the most dynamically developing fields of dentistry, which, despite developing clinical knowledge and new technologies, is still associated with many complications that may lead to the loss of the implant or the development of the disease, including peri-implantitis. One of the reasons for this condition may be the fact that dental implants cannot yield a proper osseointegration process due to the development of oral microbiota dysbiosis and the accompanying inflammation caused by immunological imbalance. This study aims to present current knowledge as to the impact of oral microflora dysbiosis and deregulation of the immune system on the course of failures observed in dental implantology. Evidence points to a strong correlation between these biological disturbances and implant complications, often stemming from improper osseointegration, pathogenic biofilms on implants, as well as an exacerbated inflammatory response. Technological enhancements in implant design may mitigate pathogen colonization and inflammation, underscoring implant success rates.

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The temporal shift of peri-implant microbiota during the biofilm formation and maturation in a canine model

Cited by 9 publications

References 59 publications

Fusobacterium nucleatum: The Opportunistic Pathogen of Periodontal and Peri-Implant Diseases

Fusobacterium nucleatum: The Opportunistic Pathogen of Periodontal and Peri-Implant Diseases

Species-level characterization of saliva and dental plaque microbiota reveals putative bacterial and functional biomarkers of periodontal diseases in dogs

How Can Imbalance in Oral Microbiota and Immune Response Lead to Dental Implant Problems?

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