The temporal relationship between increases in airway responsiveness to histamine and late asthmatic responses induced by occupational agents

Durham, Stephen R.; Graneek, B J; Hawkins, R; Taylor, A J Newman

doi:10.1016/0091-6749(87)90161-8

Cited by 110 publications

(39 citation statements)

References 18 publications

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“…[25]. Furthermore, exposure to allergen is known to worsen BHR [3,26] and improvement in BHR may occur following cessation of exposure [27]. In the current study, although the confidence intervals were large, those with an immediate skin-prick test reaction of 3 mm to an AA-HSA conjugate, were associated with a four times higher prevalence (OR 3.89, 95% CI 1.03±14.73) of BHR.…”

Section: Discussionmentioning

confidence: 50%

“…Laboratory based studies have shown that nonspecific bronchial hyperresponsiveness (BHR) is a common accompaniment to occupational asthma and that BHR may worsen with exposure to the relevant sensitizer [3]. Bronchial responsiveness is routinely measured as part of the laboratory diagnosis of occupational asthma and is used increasingly in surveys of asthma among working populations.…”

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confidence: 99%

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Risk factors for bronchial hyperresponsiveness in workers exposed to acid anhydrides

Barker¹,

Tongeren²,

Harris³

et al. 2000

Eur Respir J

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Risk factors for bronchial hyperresponsiveness have previously been established in the general community. In settings where occupational asthma is a risk, it has not been established whether occupational sensitization or measures of exposure are important.Bronchial responsiveness to histamine was measured in a cohort of 506 workers exposed to acid anhydrides. Skin-prick tests were performed with conjugates of phthalic, maleic and trimellitic anhydride with human serum albumin and with common inhalant allergens. Employment and smoking histories were recorded. Occupational exposure was measured using personal air samplers and estimates of past exposure made by retrospective exposure assessment.Three hundred and seventy workers (73%) had bronchial responsiveness measured (median age 39 yrs, range 18±77) and 46 (12%) of these were hyperresponsive (provocative dose causing a 20% fall in forced expiratory volume in one second (FEV1; PD20) #8 mmol). Twelve (3%) of these responsive workers had a skin-prick test reaction to an acid anhydride conjugate, 124 (34%) to a common inhalant allergen, and 148 (40%) were current smokers. Multivariate analysis showed that occupational sensitization, sensitization to a common inhalant allergen, age, and pack-years of smoking were independent risk factors for bronchial hyperresponsiveness. Of these only occupational sensitization was completely independent of baseline FEV1.It is concluded that sensitization to acid anhydrides is a significant risk factor for bronchial hyperresponsiveness. However, measures of personal acid anhydride exposure were not associated with bronchial hyperresponsiveness. Eur Respir J 2000; 15: 710±715.

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Section: Discussionmentioning

confidence: 50%

mentioning

confidence: 99%

Risk factors for bronchial hyperresponsiveness in workers exposed to acid anhydrides

Barker¹,

Tongeren²,

Harris³

et al. 2000

Eur Respir J

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“…PAGGIARO et al [127] found that the development of DAR induced by isocyanates was associated with more severe OA, as assessed by the duration of symptoms, baseline airway obstruction, and level of NSBHR. Several studies have documented that repeated exposure to LMW agents can induce changes in the pattern of reaction from isolated LAR to DAR [128][129][130]. DURHAM et al [129] observed that increasing the intensity of exposure to the causal agent (i.e.…”

Section: Research Purposesmentioning

confidence: 99%

“…A number of studies have documented that asthmatic reactions induced by sensitizing agents can be associated with an increase in NSBHR that may persist for several hours to several weeks [45][46][47][48][49][50][51][52]. This increase in NSBHR may help to distinguish asthmatic reactions due to specific hyperresponsiveness mechanisms from nonspecific bronchoconstriction triggered by irritants.…”

Section: Assessment Of Bronchial Responsementioning

confidence: 99%

Inhalation challenges with agents causing occupational asthma

Vandenplas¹,

Jl²

1997

Eur Respir J

124

103

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Occupational asthma (OA) is steadily emerging as the principal cause of respiratory disease due to the workplace environment. One of the key means to ascertain diagnosis of OA is specific inhalation challenge (SIC) with occupational agents. This review: 1) describes the methodology of SIC, with a special emphasis on procedures aimed at increasing the safety and validity of these tests; and 2) outlines the roles of SIC in the diagnosis of OA in clinical and medicolegal assessment, epidemiological studies, surveillance programmes and the investigation of the pathophysiological mechanisms of asthma and OA. We discuss areas of future development, including the development of apparatus which allows exposure of subjects to low and stable concentrations of the occupational agent and the assessment of preventive procedures.

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“…In allen übrigen Fällen wird aus ärztlicher Sicht von jedem Umgang mit Aminound Nitroaromaten abgeraten, da hier das Ausmaß des angeborenen G-6-PDHMangels, insbesondere unter der unfallbedingten Einwirkung von Amino-und Nitroaromaten zu schwersten hämolytischen Krisen mit lebensbedrohenden Beanspruchungen führen kann. [42]. So ist die UBH nach einer spezifischen bronchialen Überempfindlich-keitsreaktion meist für einige Tage gesteigert.…”

Section: Bewertungunclassified

Einsatz klinischer und immunologischer Laborparameter in der Arbeitsmedizin bei der Einwirkung von Gefahrstoffen [Biomonitoring Methods in German language, 2010]

Leng¹,

Lewalter²

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Analytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe: Analysen in biologischem Material , 19. Lieferung, Ausgabe 2010 Der Artikel enthält folgende Kapitel: Einleitung Anhang: Analytische Methoden (alphabetisch) Acetylcholinesterase (AChE)―kein G‐Satz δ‐Aminolävulinsäure im Harn ― G2 Blei δ‐Aminolävulinsäure‐Dehydratase (ALDH) ― G2 Blei Ascorbinsäurespiegel ― G15 Chrom Calcium und Magnesium―G34 Fluor Cellular Antigen Stimulation Test (CAST) ‐ G23 Obstruktive Atemwegserkrankungen G27 Isocyanate Freie Erythrozytenporphyrine (FEP)‐G2 Blei β‐Glucuronidase ― G8 Benzol G33 Aromatische Nitro‐ oder Aminoverbindungen G40 Krebserzeugende Stoffe, z. B. Phenole Glucose‐6‐Phosphat‐Dehydrogenase (G‐6‐PDH) ― G33 Aromatische Nitro‐ oder Aminoverbindungen Hämatologie (Cytologie, Differentialblutbild) ― G8 Benzol Harnzytologie ― G33 Aromatische Nitro‐ oder Aminoverbindungen Histamin‐Releasing‐Test‐G24 Hauterkrankungen 8‐Hydroxy‐2'‐desoxyguanosin(8‐OHdG)‐G15Chrom Immunglobuline (IgE und IgG) ― G23 Obstruktive Atemwegserkrankungen G27 Isocyanate Kohlenmonoxid‐Hämoglobin (CO‐Hb)‐G7 Kohlenmonoxid Kreatinin‐G9 Quecksilber G32 Cadmium G40 Krebserzeugende Stoffe, z. B. Phenole Leberenzyme (GGT, AST, ALT, LDH, GLDH)‐G40 Krebserzeugende Stoffe, z. B. DMF Lymphozytentransformationstest‐G8 Benzol G40 Krebserzeugende Stoffe, z. B. Beryllium Methämoglobin (MetHb) ‐ G33 Aromatische Nitro‐ oder Aminoverbindungen α 1 ‐Mikroglobulin (α 1 ‐MG)‐G9 Quecksilber G32 Cadmium β 2 ‐Mikroglobulin (β 2 ‐MG) ― G9 Quecksilber G32 Cadmium N‐Acetyl‐β‐D‐Glucosaminidase (β‐NAG) ‐ G9 Quecksilber G32 Cadmium N‐Acetyltransferase (NAT) ― G33 Aromatische Nitro‐ oder Aminoverbindungen Neurotoxische Esterase (NTE) ― kein G‐Satz Nuclear Matrix Protein 22 (NMP22) ‐ G33 Aromatische Nitro‐ oder Aminoverbindungen Uridin‐Diphosphat‐Glucuronosyltransferase (UGT) ‐ G8 Benzol G40 Krebserzeugende Stoffe, z. B. Phenole

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The temporal relationship between increases in airway responsiveness to histamine and late asthmatic responses induced by occupational agents

Cited by 110 publications

References 18 publications

Risk factors for bronchial hyperresponsiveness in workers exposed to acid anhydrides

Risk factors for bronchial hyperresponsiveness in workers exposed to acid anhydrides

Inhalation challenges with agents causing occupational asthma

Einsatz klinischer und immunologischer Laborparameter in der Arbeitsmedizin bei der Einwirkung von Gefahrstoffen [Biomonitoring Methods in German language, 2010]

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