The temporal and long‐term impact of donor body mass index on recipient outcomes after kidney transplantation – a retrospective study

Naik, Abhijit S.; Zhong, Yingchao; Parasuraman, Ravi; Doshi, Mona D.; Norman, Silas P.; Lu, Yee; Shaban, Eman; Shahinian, Vahakn B.; Schaubel, Douglas E.

doi:10.1111/tri.13505

Cited by 13 publications

(21 citation statements)

References 33 publications

(40 reference statements)

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“…This pattern highlights the need for larger prospective studies capable of further exploring these variables. Of note, however, is the fact that in our study average BMI of the donors was 24.28 kg/m 2 and only 6 donors had a BMI >30 kg/m 2 , previously identified as a risk threshold [28]; thus, our results should be interpreted with caution.…”

Section: Discussioncontrasting

confidence: 63%

Outcomes in Living Donor Kidney Transplantation: The Role of Donor’s Kidney Function

Torreggiani

Esposito

Martinelli

et al. 2021

Kidney Blood Press Res

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Introduction: Living donor kidney transplant (LDKT) is one of the best therapeutic options for end-stage kidney disease (ESKD). Guidelines identify different estimated glomerular filtration rate (eGFR) thresholds to determine the eligibility of donors. The aim of our study was to evaluate whether pretransplant donor eGFR was associated with kidney function in the recipient. Methods: We retrospectively studied LDKT recipients who received a kidney graft between September 1, 2005, and June 30, 2016 in the same transplant center in France and that had eGFR data available at 3, 12, 24, and 36 months posttransplant. Results: We studied 90 donor-recipient pairs. The average age at time of transplant was 51.47 ± 10.95 for donors and 43.04 ± 13.52 years for recipients. Donors’ average eGFR was 91.99 ± 15.37 mL/min/1.73 m2. Donor’s age and eGFR were significantly correlated (p < 0.0001, r2 0.023). Donor’s age and eGFR significantly correlated with recipient’s eGFR at 3, 12, and 24 months posttransplant (age: p < 0.001 at all intervals; eGFR p = 0.001, 0.003, and 0.016, respectively); at 36 months, only donor’s age significantly correlated with recipient’s eGFR. BMI, gender match, and year of kidney transplant did not correlate with graft function. In the multivariable analyses, donor’s eGFR and donor’s age were found to be associated with graft function; correlation with eGFR was lost at 36 months; and donor’s age retained a strong correlation with graft function at all intervals (p < 0.001). Conclusions: Donor’s eGFR and age are strong predictors of recipient’s kidney function at 3 years. We suggest that donor’s eGFR should be clinically balanced with other determinants of kidney function and in particular with age.

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Section: Discussioncontrasting

confidence: 63%

Outcomes in Living Donor Kidney Transplantation: The Role of Donor’s Kidney Function

Torreggiani

Esposito

Martinelli

et al. 2021

Kidney Blood Press Res

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“…Previous studies have shown that donor obesity is associated with DGF, primary non‐function (PNF), acute rejection and inferior long‐term kidney allograft survival [4,12,13]. Naik et al .…”

Section: Introductionmentioning

confidence: 99%

“…Naik et al . [13] demonstrated that with both living and deceased kidney donors, having a BMI ≥ 35 kg/m 2 , was associated with an increased risk of long‐term allograft failure (hazard ratio 1.22; 95% CI 1.14–1.31, P < 0.01). Alhamad et al .…”

Section: Introductionmentioning

confidence: 99%

Impact of donor obesity on allograft outcomes after kidney transplantation adjusted for kidney donor profile index – a national cohort study

et al. 2021

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Obesity in deceased kidney donors is a known risk factor for poor allograft outcomes. The Kidney Donor Profile Index (KDPI) has been introduced to predict graft survival in deceased donor kidney transplantation (DDKT). Obesity, however, is not included in KDPI. We study the impact of donor obesity on DDKT outcomes after adjusting for organ quality by KDPI. The Organ Procurement Transplantation Network/United Network for Organ Sharing (OPTN/UNOS) data of DDKT from 2005 to 2017, with donor BMI ≥ 18.5 kg/m2 and weight >80 kg were included. There was a total of 66 382 DDKTs with 10 917 death‐censored graft failures. For KDPI ≤ 30%, the 10‐year death‐censored graft survival (DCGS) rates among donor BMI < 30, 30–35, 35–40, 40–45 and ≥45 kg/m2 groups were 75.9%, 75.4%, 76.1%, 74.9% and 79.6%, respectively. For KDPI > 30%, 10‐year DCGS rates were 67.5%, 66.1%, 65.9%, 62.6% and 63.2%, respectively. After adjusting for known confounding factors including KDPI, donor obesity was not independently associated with an increased risk for graft failure. In DDKT with donor weight >80 kg, donor obesity was not associated with a lower long term DCGS compared to non‐obesity when KDPI ≤ 30%.

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“…BMI is another important factor affecting transplantation outcomes, as donor obesity is a reported risk factor for graft failure. In contrast, smaller recipients of larger donor kidneys have been linked to better long-term outcomes (10). This difference in BMI can also reduce the possibility of graft loss for sex-mismatched recipients (11).…”

Section: Introductionmentioning

confidence: 99%

Analysis of Factors Influencing Kidney Function of Recipients After Renal Transplantation in Southwestern China: A Retrospective Study

Xin

Zhou

et al. 2020

Front. Med.

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The temporal and long‐term impact of donor body mass index on recipient outcomes after kidney transplantation – a retrospective study

Cited by 13 publications

References 33 publications

Outcomes in Living Donor Kidney Transplantation: The Role of Donor’s Kidney Function

Outcomes in Living Donor Kidney Transplantation: The Role of Donor’s Kidney Function

Impact of donor obesity on allograft outcomes after kidney transplantation adjusted for kidney donor profile index – a national cohort study

Analysis of Factors Influencing Kidney Function of Recipients After Renal Transplantation in Southwestern China: A Retrospective Study

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