Analysis of Factors Influencing Kidney Function of Recipients After Renal Transplantation in Southwestern China: A Retrospective Study

Xin, Zhaodan; Wu, Lijuan; Zhou, Juan; Zhuang, Jie; Wu, Peng; Song, Ting; Lin, Tao; Lu, Xiaojun; Ying, Binwu

doi:10.3389/fmed.2020.519582

Cited by 2 publications

(4 citation statements)

References 42 publications

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“…In the present study, the average age of kidney transplant donors was 32.4 ± 1.6 years (P-value = 0.02) compared to 49.8 years in the study of de Kok et al (27). Thongprayoon et al (22) and Xin et al (24) considered the donor's age as one of the most critical factors affecting kidney transplant rejection. According to Hashemian et al (23), individuals aged 20 -40 years were the most suitable kidney transplant donors whose grafts had a higher cumulative probability of survival.…”

Section: The Average Ages Of Kidney Donors and Recipientscontrasting

confidence: 49%

“…In studies conducted by Thongprayoon et al (22), Xin et al (24), and de Kok et al (27), 67%, 73.4%, and 58.5% of the patients encountering EGL were men, respectively. As reported by Xin et al (24) and Zukowski et al (25), the masculinity of transplant recipients increased the risk of transplant rejection, and EGL was reported to be more likely to occur in men than in women. Yet, the effect of gender mismatch between the recipient and donor on EGL remains unclear (26).…”

Section: Gender Of Patientsmentioning

confidence: 92%

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Risk Factors and Causality of Early Graft Loss in Kidney Transplanted Patients in Northwestern Iran: A 10-Year Retrospective Study

Mohammad Rahimi,

Hemmati,

Zomorrodi

et al. 2023

Shiraz E-Med J

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Background: Early graft loss (EGL) is one of the rare complications of kidney transplantation. Several factors play a role in the occurrence of EGL in kidney transplant recipients, which must be identified and limited. Objectives: This ten-year retrospective study was conducted in a single center on 32 kidney transplant recipients with EGL to determine the reasons for and risk factors of kidney transplant rejection in Iran. Methods: This descriptive-analytical study’s population included 605 kidney transplant recipients receiving kidneys during the last ten years in our center. The diagnosis of EGL was based on renal allograft biopsy examination and primary clinical complications, including a rapid increase in serum creatinine. The age, gender, blood group, and rhesus (Rh) of both donors and recipients, as well as the kinship between the donor and recipient (relative and non-relative), right/left-sided living donor/recipient kidneys, primary kidney disease, the presence of underlying disease in the recipient, dialysis duration, the year of kidney transplantation, transplant survival time, patient survival time, and complications (surgery and others) were gathered. The data were analyzed using SPSS version 18. Results: In this study, 32 out of 605 kidney transplant recipients (5.28%) experienced EGL (53.1% male and 46.9% female, average age of 41.12 years). The duration of kidney function after transplantation was 5.56 ± 0.13 days. The transplanted kidneys were functional between 72 hours and one week after transplantation in 34.4% of the patients. The causes of EGL were found to be tissue rejection in 31.3% of the patients and vascular thrombosis and hyperacute rejection in 21.8%. Nephrectomy occurred in 41% of the patients, and 43.75% died because of a heart attack. Conclusions: Our findings supported previous studies' results, suggesting that EGL is associated with receiving an incompatible kidney transplant and surgery-related complications, including bleeding and thrombosis.

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Section: The Average Ages Of Kidney Donors and Recipientscontrasting

confidence: 49%

Section: Gender Of Patientsmentioning

confidence: 92%

Risk Factors and Causality of Early Graft Loss in Kidney Transplanted Patients in Northwestern Iran: A 10-Year Retrospective Study

Mohammad Rahimi,

Hemmati,

Zomorrodi

et al. 2023

Shiraz E-Med J

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Section: Discussionmentioning

confidence: 99%

“…Various studies have reported that recipient BMI has a significant effect on graft function, especially in the early period [21][22][23]. Xin et al retrospectively evaluated 2462 KTx cases and reported that recipient BMI was an independent factor in predicting graft function [22]. Similarly, Zhao et al noted that donor GFR and recipient body weight were independent factors affecting renal function in the second year after transplantation [23].…”

Section: Discussionmentioning

confidence: 99%

The Predictive Value of Donor Renal Functions, Graft Weight, Recipient Body Mass Index, and Human Leucocyte Antigen Match Regarding Early Graft Functions

Açıkgöz¹,

Akıncı²

2023

Cureus

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Background and objective Graft performance is the most important postoperative parameter for patients undergoing kidney transplantation (KTx). The renal function of the donor is reported to be correlated with graft function after KTx. The body mass index (BMI) is also one of the important parameters involved in the prediction of graft function. The aim of this retrospective study was to examine the relationship between early postoperative graft function in patients undergoing KTx and donor cystatin C and estimated glomerular filtration rate (e-GFR) levels, graft weight/recipient BMI (G/B) ratio, and human leukocyte antigen (HLA) tissue compatibility. Materials and methods A total of 215 cases (215 donors, 215 recipients) who underwent KTx at our center between January 2018 and December 2022 were included in the study. Patients' age, sex, BMI, preoperative donor serum cystatin C and e-GFR levels, HLA tissue compatibility, graft weights, and recipient creatinine levels were recorded one week postoperatively. The Kolmogorov-Smirnov test and histogram plots were used to analyze the conformity of the variables to the normal distribution and Spearman's correlation test was used to analyze the relationship between variables. Results A negative correlation was identified between recipient creatinine level and G/B ratio and donor e-GFR (r = −0.256 and −0.137, respectively). Donor cystatin C level showed a positive correlation with recipient creatinine level (r = 0.242). No significant correlation was noted in terms of tissue matching rates (p = 0.616). Conclusion Although these three parameters are correlated with early graft functions, the graft weight/recipient BMI ratio has the strongest correlation.

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Analysis of Factors Influencing Kidney Function of Recipients After Renal Transplantation in Southwestern China: A Retrospective Study

Cited by 2 publications

References 42 publications

Risk Factors and Causality of Early Graft Loss in Kidney Transplanted Patients in Northwestern Iran: A 10-Year Retrospective Study

Risk Factors and Causality of Early Graft Loss in Kidney Transplanted Patients in Northwestern Iran: A 10-Year Retrospective Study

The Predictive Value of Donor Renal Functions, Graft Weight, Recipient Body Mass Index, and Human Leucocyte Antigen Match Regarding Early Graft Functions

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