2014
DOI: 10.1189/jlb.0313171
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The teleost acute-phase inflammatory response and caspase activation by a novel alarmin-like ligand

Abstract: This study tested the hypothesis that NCAMP-1 has alarmin-like properties and activates the caspase-1-binding site in cells of the teleost bone marrow (equivalent). In mammals, alarmins have been studied extensively; however, in teleosts, little is known about their identity and functions. Similar to alarmins, NCAMP-1 has a broad spectrum of bacteriolytic activity. NCAMP-1 is constitutively present in CF serum, and levels were increased following infection with Edwardsiella ictaluri Binding to AK cells was det… Show more

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Cited by 4 publications
(8 citation statements)
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“…3 ). The molecular weight discrepancy between the secreted and recombinant NCAMP-1 forms has been previously noted in catfish [ 38 ]. The very basic nature of the protein is partly responsible for inaccuracies in SDS gel electrophoresis migration.…”
Section: Resultsmentioning
confidence: 99%
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“…3 ). The molecular weight discrepancy between the secreted and recombinant NCAMP-1 forms has been previously noted in catfish [ 38 ]. The very basic nature of the protein is partly responsible for inaccuracies in SDS gel electrophoresis migration.…”
Section: Resultsmentioning
confidence: 99%
“…The purified and subsequently sequenced protein [nonspecific cytotoxic cell cationic antimicrobial protein (e.g. NCAMP-1)] is a novel phylogenetically conserved H1X-like protein [ 38 , 40 ]. We now show similarities and distinctions between the alarmin functions of NCAMP-1 and ATP, and we suggest that NCAMP-1 shares similarities also with other alarmins such as high mobility group box-1/HMGB-1 [ 7 8 ].…”
Section: Discussionmentioning
confidence: 99%
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